SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 ALA A  95
ASP A  94
ILE A  40
PRO A  31
ILE A 219
 None
 0.97A 2o4lA-4p5pA:
undetectable		 2o4lA-4p5pA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 11 ILE A  44
LEU A   5
ALA A  95
ILE A  96
ILE A 131
 None
 1.10A 3b2rB-4p5pA:
undetectable		 3b2rB-4p5pA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 ALA A  99
ILE A  44
VAL A  45
ILE A  47
PRO A  53
 None
 0.89A 3ekqA-4p5pA:
undetectable		 3ekqA-4p5pA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 ALA A  95
ASP A  94
ILE A  40
PRO A  31
ILE A 219
 None
 0.99A 3ekwB-4p5pA:
undetectable		 3ekwB-4p5pA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 6 GLY A 100
THR A  21
GLU A  27
GLU A 162
 None
 1.07A 3fpjA-4p5pA:
2.8		 3fpjA-4p5pA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 5 ILE A 139
PHE A 174
ASP A 178
GLU A 177
 None
 1.11A 3kp6A-4p5pA:
undetectable
3kp6B-4p5pA:
undetectable		 3kp6A-4p5pA:
21.93
3kp6B-4p5pA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 6 ALA A 136
ILE A 139
HIS A 115
ASN A 140
 None
 0.91A 3nneG-4p5pA:
1.7		 3nneG-4p5pA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 11 ALA A 218
ILE A 131
GLY A 129
ILE A 128
THR A 156
 None
 0.95A 4qgiA-4p5pA:
undetectable		 4qgiA-4p5pA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 4 VAL A   7
ALA A  99
PHE A 108
THR A 104
 None
 1.31A 4z4fA-4p5pA:
2.7		 4z4fA-4p5pA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 4 VAL A   7
ALA A  99
PHE A 108
THR A 104
 None
 1.29A 4z4hA-4p5pA:
2.8		 4z4hA-4p5pA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 9 ALA A 218
ILE A 131
GLY A 129
ILE A 128
THR A 156
 None
 1.02A 5kr2C-4p5pA:
undetectable		 5kr2C-4p5pA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 9 ILE A  97
ALA A  95
ILE A  96
ILE A 203
ALA A 130
 None
 1.03A 5mvmA-4p5pA:
undetectable
5mvmE-4p5pA:
undetectable		 5mvmA-4p5pA:
16.04
5mvmE-4p5pA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 7 PHE A 108
ASP A 107
GLY A 100
GLY A  22
 None
 1.01A 5n9xA-4p5pA:
3.1		 5n9xA-4p5pA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 PHE A 215
ALA A 212
PHE A 108
LEU A   5
THR A  29
 None
 0.87A 5tl8A-4p5pA:
undetectable		 5tl8A-4p5pA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 4p5p THIJ/PFPI FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 ALA A  95
ASP A  94
ILE A  40
PRO A  31
ILE A 219
 None
 0.98A 6difA-4p5pA:
undetectable		 6difA-4p5pA:
17.22