SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4p5y GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN
(Clostridium
perfringens) 		5 / 12 ASN A  81
LEU A  77
GLY A 122
TYR A  76
ALA A 154
 None
 1.18A 1hvyA-4p5yA:
undetectable		 1hvyA-4p5yA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_1
(HYPOTHETICAL PROTEIN)		 4p5y GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN
(Clostridium
perfringens) 		4 / 4 GLU A 156
ASP A  75
ASP A  17
TYR A 160
 None
 0.85A 2yvlA-4p5yA:
undetectable		 2yvlA-4p5yA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4p5y GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN
(Clostridium
perfringens) 		3 / 3 GLU A 156
ASP A  75
TYR A 160
 None
 0.81A 2yvlB-4p5yA:
undetectable		 2yvlB-4p5yA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4p5y GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN
(Clostridium
perfringens) 		4 / 5 ASN A  81
THR A 143
SER A 153
SER A  49
 None
 1.33A 3hlwB-4p5yA:
undetectable		 3hlwB-4p5yA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 4p5y GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN
(Clostridium
perfringens) 		4 / 5 ILE A  46
GLN A  80
ARG A  79
GLU A  43
 None
None
NGA  A 201 (-2.3A)
None
 1.21A 5fseC-4p5yA:
undetectable		 5fseC-4p5yA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4p5y GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN
(Clostridium
perfringens) 		3 / 3 ARG A 121
ASN A 116
ASP A 146
 None
None
NGA  A 201 ( 4.7A)
 0.85A 5gwxA-4p5yA:
undetectable		 5gwxA-4p5yA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4p5y GLYCOSYL HYDROLASE,
FAMILY
31/FIBRONECTIN TYPE
III DOMAIN PROTEIN
(Clostridium
perfringens) 		4 / 5 ILE A  63
PHE A 159
ASN A 108
TYR A  76
 None
 1.11A 6a93B-4p5yA:
undetectable		 6a93B-4p5yA:
19.84