SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 TRP A 290
ALA A 297
VAL A 288
 None
 0.94A 1c4dA-4p63A:
undetectable
1c4dB-4p63A:
undetectable		 1c4dA-4p63A:
6.56
1c4dB-4p63A:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 173
ASP A 240
LEU A 244
ILE A 207
THR A 172
 None
 1.05A 1ra3A-4p63A:
undetectable		 1ra3A-4p63A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 173
ASP A 240
LEU A 244
ILE A 207
THR A 172
 None
 1.00A 1rb3B-4p63A:
undetectable		 1rb3B-4p63A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE
(Pyrococcus
horikoshii) 		4 / 4 VAL A 317
LEU A  89
ILE A  86
LEU A  82
 None
 0.98A 2byoA-4p63A:
undetectable		 2byoA-4p63A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 173
ASP A 240
LEU A 244
ILE A 207
THR A 172
 None
 1.02A 2drcB-4p63A:
undetectable		 2drcB-4p63A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 106
ILE A 235
LEU A 233
GLY A 218
SER A 216
 NAD  A 401 (-3.5A)
None
None
None
None
 1.10A 2e7fB-4p63A:
undetectable		 2e7fB-4p63A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 294
ILE A 258
ILE A 268
ALA A 267
 None
 0.76A 2i30A-4p63A:
undetectable		 2i30A-4p63A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 173
ASP A 240
LEU A 244
ILE A 207
THR A 172
 None
 1.02A 3drcB-4p63A:
undetectable		 3drcB-4p63A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE
(Pyrococcus
horikoshii) 		4 / 5 PHE A 176
PHE A 157
ILE A 217
GLY A 218
 None
 0.70A 4ejjC-4p63A:
undetectable		 4ejjC-4p63A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE
(Pyrococcus
horikoshii) 		4 / 6 GLU A  62
ARG A  63
GLU A  58
ARG A 336
 None
 1.25A 4kr3A-4p63A:
undetectable		 4kr3A-4p63A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE
(Pyrococcus
horikoshii) 		5 / 11 ALA A 173
ASP A 240
LEU A 244
ILE A 207
THR A 172
 None
 1.06A 4p66A-4p63A:
undetectable		 4p66A-4p63A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A 103
GLY A 104
GLY A 218
PHE A 176
ILE A 212
 NAD  A 401 (-3.6A)
None
None
None
None
 1.16A 4qoiA-4p63A:
2.6
4qoiB-4p63A:
3.2		 4qoiA-4p63A:
20.93
4qoiB-4p63A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A  71
LEU A  89
ALA A 255
VAL A  57
ARG A  61
 None
 1.36A 5g44A-4p63A:
undetectable		 5g44A-4p63A:
21.07