SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p69'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		4 / 4 ILE A 173
LEU A 153
VAL A 156
ALA A 140
 None
 0.96A 1mz9A-4p69A:
undetectable		 1mz9A-4p69A:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		5 / 9 GLU A 296
ILE A 287
ALA A 261
VAL A 259
PHE A 257
 None
 1.39A 2drdA-4p69A:
undetectable		 2drdA-4p69A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		5 / 10 ILE A 528
ILE A 438
LEU A 426
ASN A 423
VAL A 471
 None
 1.26A 2nnhB-4p69A:
undetectable		 2nnhB-4p69A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		4 / 5 LEU A 160
PRO A 161
LEU A 162
ILE A 226
 None
 0.83A 2qd4A-4p69A:
undetectable		 2qd4A-4p69A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		5 / 10 ILE A 157
TRP A 166
ILE A 173
ASP A 172
LEU A 234
 None
 1.21A 3eqmA-4p69A:
undetectable		 3eqmA-4p69A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		5 / 10 PHE A 335
PHE A 375
PHE A 378
PHE A 331
PHE A 312
 None
 1.36A 3t3rD-4p69A:
undetectable		 3t3rD-4p69A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		5 / 11 LEU A 267
ALA A 265
LEU A 283
ARG A 272
GLY A 288
 None
 1.19A 3uudA-4p69A:
undetectable		 3uudA-4p69A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		4 / 8 LEU A  53
ASP A  18
TYR A  21
PHE A  24
 None
 0.78A 4drjB-4p69A:
undetectable		 4drjB-4p69A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		4 / 7 ALA A 266
ALA A 261
PRO A 262
LEU A 139
 None
 0.92A 4du2A-4p69A:
undetectable		 4du2A-4p69A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		4 / 4 LEU A 160
PRO A 161
LEU A 162
ILE A 226
 None
 0.85A 4f4dB-4p69A:
undetectable		 4f4dB-4p69A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A 413
ALA A 370
LEU A 305
PHE A 331
THR A 327
 None
 1.42A 4iaqA-4p69A:
undetectable		 4iaqA-4p69A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		4 / 7 ASP A 172
THR A 238
LEU A 153
LEU A 160
 None
 0.98A 4ib4A-4p69A:
undetectable		 4ib4A-4p69A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		3 / 3 HIS A 468
TRP A 425
SER A 247
 None
 1.09A 4lrhD-4p69A:
undetectable		 4lrhD-4p69A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		4 / 6 TYR A  86
ASP A  18
ILE A  98
TYR A  54
 None
 1.49A 5igyA-4p69A:
5.8		 5igyA-4p69A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		5 / 12 GLY A 232
ALA A 207
LEU A 200
ALA A  38
PRO A 161
 None
 1.25A 5jglB-4p69A:
undetectable		 5jglB-4p69A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		5 / 12 ILE A 157
TRP A 166
ILE A 173
ASP A 172
LEU A 234
 None
 1.18A 5jkvA-4p69A:
undetectable		 5jkvA-4p69A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL7_A_ASDA601_1
(AROMATASE)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		5 / 10 ILE A 157
TRP A 166
ILE A 173
ASP A 172
LEU A 234
 None
 1.16A 5jl7A-4p69A:
undetectable		 5jl7A-4p69A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		3 / 3 VAL A 360
TYR A 357
GLN A 358
 None
 0.76A 5qgtA-4p69A:
undetectable		 5qgtA-4p69A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A 305
PHE A 378
PHE A 375
LEU A 380
VAL A 379
 None
 1.33A 6a93B-4p69A:
undetectable		 6a93B-4p69A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		3 / 3 ARG A 203
ARG A 470
ARG A 365
 None
 1.02A 6bplA-4p69A:
undetectable
6bplB-4p69A:
undetectable		 6bplA-4p69A:
10.39
6bplB-4p69A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		3 / 3 TYR A 441
HIS A 536
PHE A 532
 None
 1.05A 6esmA-4p69A:
undetectable		 6esmA-4p69A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		4 / 5 LEU A 153
THR A 181
ARG A 171
ARG A 568
 None
 1.09A 6ew0B-4p69A:
undetectable		 6ew0B-4p69A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		4 / 5 LEU A 153
THR A 181
ARG A 171
ARG A 568
 None
 1.09A 6ew0D-4p69A:
undetectable		 6ew0D-4p69A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		5 / 6 LEU A 213
LEU A 153
THR A 181
ARG A 171
ARG A 568
 None
 1.43A 6ew0G-4p69A:
undetectable		 6ew0G-4p69A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		4 / 5 LEU A 153
THR A 181
ARG A 171
ARG A 568
 None
 1.09A 6ew0H-4p69A:
undetectable		 6ew0H-4p69A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE
(Escherichia
coli) 		4 / 5 LEU A 153
THR A 181
ARG A 171
ARG A 568
 None
 1.09A 6ew0I-4p69A:
undetectable		 6ew0I-4p69A:
9.87