SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 4p6b EST-Y29
(metagenome) 		5 / 12 LEU A  71
GLY A 260
GLY A 259
ALA A  68
LEU A  67
 None
 1.00A 1bx4A-4p6bA:
undetectable		 1bx4A-4p6bA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4p6b EST-Y29
(metagenome) 		4 / 8 SER A  81
ALA A 184
PHE A  86
ILE A 181
 None
 1.08A 1gm7A-4p6bA:
undetectable
1gm7B-4p6bA:
undetectable		 1gm7A-4p6bA:
19.59
1gm7B-4p6bA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 4p6b EST-Y29
(metagenome) 		5 / 9 LEU A 240
VAL A  39
VAL A  13
GLY A  38
TYR A 222
 None
 1.35A 1ikvA-4p6bA:
undetectable		 1ikvA-4p6bA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4p6b EST-Y29
(metagenome) 		5 / 11 PHE A 208
ASP A 143
GLY A 144
PHE A 256
MET A 151
 None
 1.39A 1ju6A-4p6bA:
undetectable		 1ju6A-4p6bA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4p6b EST-Y29
(metagenome) 		5 / 10 LEU A 240
VAL A  39
VAL A  13
GLY A  38
TYR A 222
 None
 1.43A 1lw0A-4p6bA:
undetectable		 1lw0A-4p6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4p6b EST-Y29
(metagenome) 		5 / 11 LEU A 240
VAL A  39
VAL A  13
GLY A  38
TYR A 222
 None
 1.41A 1lwcA-4p6bA:
undetectable		 1lwcA-4p6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4p6b EST-Y29
(metagenome) 		5 / 9 LEU A 240
VAL A  39
VAL A  13
GLY A  38
TYR A 222
 None
 1.47A 1lwfA-4p6bA:
undetectable		 1lwfA-4p6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4p6b EST-Y29
(metagenome) 		4 / 7 ARG A  89
ALA A 156
ILE A 180
ILE A 109
 None
 0.95A 1oniD-4p6bA:
undetectable
1oniF-4p6bA:
undetectable		 1oniD-4p6bA:
15.54
1oniF-4p6bA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 4p6b EST-Y29
(metagenome) 		4 / 5 HIS A 261
ARG A 258
ILE A 109
HIS A 117
 None
 1.47A 1osvB-4p6bA:
undetectable		 1osvB-4p6bA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4p6b EST-Y29
(metagenome) 		4 / 7 ILE A 131
LEU A 114
ILE A 181
ASP A 175
 None
 0.82A 1uwjA-4p6bA:
undetectable		 1uwjA-4p6bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4p6b EST-Y29
(metagenome) 		5 / 10 LEU A 240
VAL A  39
VAL A  13
GLY A  38
TYR A 222
 None
 1.47A 2hndA-4p6bA:
undetectable		 2hndA-4p6bA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4p6b EST-Y29
(metagenome) 		5 / 10 LEU A 240
VAL A  39
VAL A  13
GLY A  38
TYR A 222
 None
 1.45A 2hnyA-4p6bA:
undetectable		 2hnyA-4p6bA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4p6b EST-Y29
(metagenome) 		4 / 6 LEU A 263
SER A 265
ASP A 269
ASP A 205
 None
 1.22A 2j2pE-4p6bA:
undetectable
2j2pF-4p6bA:
undetectable		 2j2pE-4p6bA:
19.35
2j2pF-4p6bA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4p6b EST-Y29
(metagenome) 		5 / 12 PRO A 231
ASN A 312
ILE A 131
VAL A 154
LEU A 140
 None
 1.30A 3a51B-4p6bA:
undetectable		 3a51B-4p6bA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4p6b EST-Y29
(metagenome) 		5 / 12 LEU A 278
PHE A 273
PRO A  62
GLY A 325
LEU A 324
 None
 1.29A 3j6pB-4p6bA:
undetectable		 3j6pB-4p6bA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4p6b EST-Y29
(metagenome) 		5 / 9 LEU A 240
VAL A  39
VAL A  13
GLY A  38
TYR A 222
 None
 1.39A 3lp0A-4p6bA:
undetectable		 3lp0A-4p6bA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4p6b EST-Y29
(metagenome) 		5 / 10 LEU A 240
VAL A  39
VAL A  13
GLY A  38
TYR A 222
 None
 1.41A 3lp1A-4p6bA:
undetectable		 3lp1A-4p6bA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 4p6b EST-Y29
(metagenome) 		5 / 10 LEU A 240
VAL A  39
VAL A  13
GLY A  38
TYR A 222
 None
 1.43A 3qipA-4p6bA:
undetectable		 3qipA-4p6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 4p6b EST-Y29
(metagenome) 		4 / 4 ALA A 350
HIS A 238
PHE A  18
LEU A 370
 None
 1.50A 4luhA-4p6bA:
undetectable		 4luhA-4p6bA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4p6b EST-Y29
(metagenome) 		5 / 12 ARG A 326
GLY A 341
ALA A 335
GLY A 318
TYR A 319
 None
 1.23A 4r29A-4p6bA:
undetectable		 4r29A-4p6bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 4p6b EST-Y29
(metagenome) 		5 / 11 PHE A 256
ALA A 178
ASP A 143
GLY A 262
GLY A 144
 None
 1.21A 4xp4A-4p6bA:
undetectable		 4xp4A-4p6bA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4p6b EST-Y29
(metagenome) 		5 / 12 ASP A 268
ALA A 274
PHE A 353
THR A 351
PRO A  62
 None
 1.25A 5hnzB-4p6bA:
undetectable		 5hnzB-4p6bA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4p6b EST-Y29
(metagenome) 		5 / 12 PHE A 273
LEU A 289
LEU A 324
PRO A  62
LEU A 263
 None
 1.28A 5ljcA-4p6bA:
undetectable		 5ljcA-4p6bA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4p6b EST-Y29
(metagenome) 		5 / 10 MET A 380
ARG A  24
TRP A  23
GLY A 363
LEU A 245
 None
 1.21A 5oy01-4p6bA:
undetectable
5oy07-4p6bA:
undetectable		 5oy01-4p6bA:
12.40
5oy07-4p6bA:
7.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZWR_A_9KLA402_0
(EST-Y29)		 4p6b EST-Y29
(metagenome) 		10 / 12 TYR A  57
LYS A  61
TYR A 123
PHE A 125
ILE A 141
TYR A 170
HIS A 261
GLY A 347
ALA A 348
LEU A 370
 None
 0.33A 5zwrA-4p6bA:
71.3		 5zwrA-4p6bA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZWR_B_9KLB402_0
(EST-Y29)		 4p6b EST-Y29
(metagenome) 		10 / 12 TYR A  57
SER A  58
LYS A  61
TYR A 123
PHE A 125
ILE A 141
TYR A 170
HIS A 261
ALA A 348
LEU A 370
 None
 0.53A 5zwrB-4p6bA:
70.7		 5zwrB-4p6bA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZWR_B_9KLB402_0
(EST-Y29)		 4p6b EST-Y29
(metagenome) 		6 / 12 TYR A  57
SER A  58
LYS A  61
TYR A 170
ALA A 348
LEU A 370
 None
 1.33A 5zwrB-4p6bA:
70.7		 5zwrB-4p6bA:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 4p6b EST-Y29
(metagenome) 		5 / 12 LEU A 140
GLY A 144
GLY A 262
ILE A 172
ILE A 141
 None
 0.87A 6dh3A-4p6bA:
undetectable		 6dh3A-4p6bA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4p6b EST-Y29
(metagenome) 		5 / 10 MET A 380
ARG A  24
TRP A  23
GLY A 363
LEU A 245
 None
 1.31A 6hqbA-4p6bA:
undetectable
6hqbJ-4p6bA:
undetectable		 6hqbA-4p6bA:
11.44
6hqbJ-4p6bA:
7.73