SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p6q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 4p6q MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 4 GLY A 379
VAL A 368
TRP A 411
GLY A 336
 None
 1.46A 1ng8A-4p6qA:
undetectable		 1ng8A-4p6qA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 4p6q MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 4 GLY A 379
VAL A 368
TRP A 411
GLY A 336
 None
 1.46A 1ng8B-4p6qA:
undetectable		 1ng8B-4p6qA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p6q MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 6 SER A 602
SER A 591
GLN A 482
ASP A 549
 None
 1.38A 2cl5B-4p6qA:
undetectable		 2cl5B-4p6qA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 4p6q MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 5 ASP A 348
LEU A 351
LYS A 352
ARG A 377
 None
 1.41A 2gj5A-4p6qA:
undetectable		 2gj5A-4p6qA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p6q MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 6 SER A 602
SER A 591
GLN A 482
ASP A 549
 None
 1.41A 2zvjA-4p6qA:
undetectable		 2zvjA-4p6qA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4p6q MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 5 ARG A 455
ILE A 464
TYR A 483
THR A 439
 None
 1.43A 3dgqA-4p6qA:
undetectable		 3dgqA-4p6qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 4p6q MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 546
TYR A 540
ILE A 577
LEU A 521
THR A 572
 None
 1.29A 4o5fA-4p6qA:
undetectable
4o5fB-4p6qA:
undetectable		 4o5fA-4p6qA:
18.71
4o5fB-4p6qA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4p6q MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 501
LEU A 508
LEU A 454
ALA A 479
ILE A 469
 None
 1.02A 4x1yD-4p6qA:
undetectable		 4x1yD-4p6qA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4p6q MSX2-INTERACTING
PROTEIN
(Homo
sapiens) 		4 / 5 SER A 602
SER A 591
GLN A 482
ASP A 549
 None
 1.41A 5fhrB-4p6qA:
undetectable		 5fhrB-4p6qA:
21.91