SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
4 / 6 LEU A 264
ILE A 298
GLU A 284
ASP A 288
None
1.18A 1ditH-4p6vA:
undetectable
1ditP-4p6vA:
undetectable
1ditH-4p6vA:
19.02
1ditP-4p6vA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
4 / 4 THR F  12
LEU F  16
VAL F  19
LEU F  23
None
0.71A 1fbmD-4p6vF:
undetectable
1fbmD-4p6vF:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae)
5 / 12 LEU D 139
GLY D 138
MET D 194
ALA D  22
LEU D  23
None
1.11A 1gs4A-4p6vD:
undetectable
1gs4A-4p6vD:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae;
Vibrio
cholerae)
4 / 8 THR C 173
PRO C 174
GLY C 175
THR D  35
FMN  C 301 (-3.2A)
None
None
None
0.77A 1h4oB-4p6vC:
undetectable
1h4oB-4p6vC:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio
cholerae)
5 / 12 ILE C 205
ASN C 229
GLY C 208
TYR B 378
ALA B 377
None
1.28A 1hvyB-4p6vC:
undetectable
1hvyB-4p6vC:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio
cholerae)
5 / 11 ILE C 205
ASN C 229
GLY C 208
TYR B 378
ALA B 377
None
1.40A 1ju6A-4p6vC:
undetectable
1ju6A-4p6vC:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio
cholerae)
5 / 10 ILE C 205
ASN C 229
GLY C 208
TYR B 378
ALA B 377
None
1.39A 1ju6C-4p6vC:
undetectable
1ju6C-4p6vC:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio
cholerae)
5 / 11 ILE C 205
ASN C 229
GLY C 208
TYR B 378
ALA B 377
None
1.40A 1ju6D-4p6vC:
undetectable
1ju6D-4p6vC:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio
cholerae)
5 / 12 GLY A 400
ASP E 168
ALA A 405
SER A 402
LEU A 418
None
0.90A 1kiaD-4p6vA:
undetectable
1kiaD-4p6vA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
4 / 4 THR F  12
LEU F  16
VAL F  19
LEU F  23
None
0.91A 1mz9D-4p6vF:
undetectable
1mz9D-4p6vF:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae;
Vibrio
cholerae)
4 / 8 THR C 173
PRO C 174
GLY C 175
THR D  35
FMN  C 301 (-3.2A)
None
None
None
0.80A 1oc3A-4p6vC:
undetectable
1oc3A-4p6vC:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
4 / 7 MET A  43
PHE A  58
ASN A  80
GLU A  34
None
1.33A 1t9wA-4p6vA:
undetectable
1t9wA-4p6vA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae)
5 / 9 LEU D 180
VAL B 189
ALA B 190
LEU E 188
PHE B 211
None
1.24A 1tbfA-4p6vD:
undetectable
1tbfA-4p6vD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio
cholerae)
5 / 12 GLY C 220
GLY C 208
GLY C 209
SER C 222
ASN C 182
None
1.18A 1xdsA-4p6vC:
undetectable
1xdsA-4p6vC:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
5 / 10 LEU B 168
ILE B 169
VAL B 136
ALA B 180
LEU B 176
None
1.17A 1xp0A-4p6vB:
undetectable
1xp0A-4p6vB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae)
6 / 12 ALA B 207
GLY E 189
SER E 192
LEU B 202
SER B 349
LEU B 391
None
1.29A 1ya4A-4p6vB:
2.6
1ya4A-4p6vB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
5 / 9 PHE A 131
VAL A 180
GLY A 177
VAL A 151
ILE A 149
None
1.30A 2a1oB-4p6vA:
undetectable
2a1oB-4p6vA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
3 / 3 PRO F 242
THR F 232
PRO F 234
None
None
FAD  F 502 (-4.7A)
0.46A 2d55C-4p6vF:
undetectable
2d55C-4p6vF:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio
cholerae;
Vibrio
cholerae)
5 / 12 TYR E 166
ASP B 397
VAL B 401
HIS B 398
ALA A 410
None
None
None
RBF  E 201 ( 4.9A)
None
1.23A 2g70A-4p6vE:
undetectable
2g70A-4p6vE:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio
cholerae;
Vibrio
cholerae)
5 / 12 TYR E 166
ASP B 397
VAL B 401
HIS B 398
ALA A 410
None
None
None
RBF  E 201 ( 4.9A)
None
1.29A 2g70B-4p6vE:
undetectable
2g70B-4p6vE:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio
cholerae)
3 / 3 LYS C 112
GLY C 245
PRO C 246
None
0.93A 2hreB-4p6vC:
undetectable
2hreB-4p6vC:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae)
4 / 5 LEU D  26
LEU E  29
CYH E 120
THR D 110
None
None
FE  D 301 (-2.2A)
None
1.41A 2oaxD-4p6vD:
undetectable
2oaxD-4p6vD:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio
cholerae)
5 / 12 ILE B 297
ALA B 385
GLY B 365
GLY B 361
SER E 192
None
0.84A 2okcA-4p6vB:
undetectable
2okcA-4p6vB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio
cholerae)
5 / 12 ILE B 297
ALA B 385
GLY B 365
GLY B 361
SER E 192
None
0.84A 2okcB-4p6vB:
undetectable
2okcB-4p6vB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae)
5 / 12 GLU B 402
TYR E 166
HIS B 398
VAL E  35
ASP A 401
RBF  E 201 (-4.8A)
None
RBF  E 201 ( 4.9A)
None
None
1.48A 2qeoA-4p6vB:
undetectable
2qeoA-4p6vB:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae;
Vibrio
cholerae)
4 / 5 LEU E  69
ASP E  67
ALA E  68
ILE F   4
None
0.83A 2qhfA-4p6vE:
undetectable
2qhfA-4p6vE:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
4 / 7 ILE E  84
GLN E  92
LEU F  23
LEU F  16
None
1.07A 2qqcB-4p6vE:
undetectable
2qqcC-4p6vE:
undetectable
2qqcB-4p6vE:
21.11
2qqcC-4p6vE:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
4 / 8 ILE B 306
PHE B 341
GLY B 300
GLY B 299
None
0.84A 2qx4A-4p6vB:
undetectable
2qx4B-4p6vB:
undetectable
2qx4A-4p6vB:
20.05
2qx4B-4p6vB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
4 / 7 ILE A 239
ASP A 179
LEU A 178
GLY A 177
None
0.90A 2tsrA-4p6vA:
undetectable
2tsrA-4p6vA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
4 / 8 PRO B 204
PRO B 347
VAL B 348
SER B 349
None
0.81A 2v32C-4p6vB:
undetectable
2v32D-4p6vB:
undetectable
2v32C-4p6vB:
20.10
2v32D-4p6vB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
4 / 8 PRO B 204
PRO B 347
VAL B 348
SER B 349
None
0.80A 2v41C-4p6vB:
undetectable
2v41D-4p6vB:
undetectable
2v41C-4p6vB:
20.10
2v41D-4p6vB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
4 / 8 PRO B 204
PRO B 347
VAL B 348
SER B 349
None
0.84A 2v41C-4p6vB:
undetectable
2v41D-4p6vB:
undetectable
2v41C-4p6vB:
20.10
2v41D-4p6vB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
4 / 8 PRO B 204
PRO B 347
VAL B 348
SER B 349
None
0.77A 2v41G-4p6vB:
undetectable
2v41H-4p6vB:
undetectable
2v41G-4p6vB:
20.10
2v41H-4p6vB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
4 / 8 ARG A 395
ASP A 396
SER A 404
ASP A 401
None
0.92A 2xadA-4p6vA:
undetectable
2xadA-4p6vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
4 / 8 ARG A 395
ASP A 396
SER A 404
ASP A 401
None
0.91A 2xadB-4p6vA:
undetectable
2xadB-4p6vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
4 / 8 ARG A 395
ASP A 396
SER A 404
ASP A 401
None
0.90A 2xadC-4p6vA:
undetectable
2xadC-4p6vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
4 / 8 ARG A 395
ASP A 396
SER A 404
ASP A 401
None
0.92A 2xadD-4p6vA:
undetectable
2xadD-4p6vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae;
Vibrio
cholerae)
5 / 12 LEU B 174
PHE B 185
ASN B 203
VAL B 189
PHE D 189
None
1.22A 2zznA-4p6vB:
undetectable
2zznA-4p6vB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
4 / 7 VAL A 165
ILE A 245
GLN A 242
LEU A 181
None
0.86A 3bjwH-4p6vA:
undetectable
3bjwH-4p6vA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae)
5 / 10 LEU E  23
GLY E 184
ALA E 183
GLY D 192
LEU D 190
FMN  C 301 (-3.2A)
None
None
None
None
0.93A 3em3A-4p6vE:
undetectable
3em3A-4p6vE:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
3 / 3 MET A 388
CYH A 421
PRO A 385
None
1.23A 3h52C-4p6vA:
undetectable
3h52C-4p6vA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
5 / 12 GLY B 361
ALA B 359
SER B 351
ALA B 344
ILE B 364
None
1.16A 3id6C-4p6vB:
undetectable
3id6C-4p6vB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
4 / 8 LEU B 104
THR B 105
GLY B  76
THR B 173
None
0.82A 3jusA-4p6vB:
undetectable
3jusA-4p6vB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
4 / 8 THR B 162
GLY B 186
ALA B 207
ILE B 386
None
0.69A 3jusA-4p6vB:
undetectable
3jusA-4p6vB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
4 / 8 LEU B 104
THR B 105
GLY B  76
THR B 173
None
0.82A 3jusA-4p6vB:
undetectable
3jusA-4p6vB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
4 / 8 THR B 162
GLY B 186
ALA B 207
ILE B 386
None
0.69A 3jusA-4p6vB:
undetectable
3jusA-4p6vB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
5 / 9 LEU B 165
THR B 162
GLY B 186
ALA B 207
ILE B 386
None
0.97A 3jusB-4p6vB:
undetectable
3jusB-4p6vB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae)
5 / 10 LEU E  49
VAL E  45
ILE E  87
LEU E  90
ILE E 116
None
1.00A 3jw3A-4p6vE:
undetectable
3jw3A-4p6vE:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
5 / 11 ILE F 279
VAL F 387
ILE F 388
ASN F 400
ILE F 401
None
1.26A 3kpcA-4p6vF:
undetectable
3kpcA-4p6vF:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae)
5 / 10 LEU E 109
ALA E  44
ILE E 122
VAL E  31
LEU E  41
None
1.04A 3ogpA-4p6vE:
undetectable
3ogpA-4p6vE:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio
cholerae)
5 / 12 LEU C  66
GLY C  54
ALA C  53
ILE C 137
LEU C  50
None
1.07A 3ogqB-4p6vC:
undetectable
3ogqB-4p6vC:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae)
5 / 12 ALA D 118
ILE D 109
ILE D 108
VAL D  51
VAL D  48
None
1.06A 3rukB-4p6vD:
undetectable
3rukB-4p6vD:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
4 / 6 ILE F  39
LEU F 123
PHE F  65
GLY F 129
None
1.06A 3sj1X-4p6vF:
undetectable
3sj1X-4p6vF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae)
4 / 6 LEU E 157
PHE E  28
LEU E  29
PHE E 180
None
0.94A 3wg7P-4p6vE:
2.1
3wg7W-4p6vE:
undetectable
3wg7P-4p6vE:
22.35
3wg7W-4p6vE:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
4 / 5 PHE A 131
GLY A 177
ILE A 149
VAL A 189
None
0.80A 3wrkA-4p6vA:
undetectable
3wrkA-4p6vA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio
cholerae)
5 / 12 GLY E 184
PHE D 188
VAL D  25
ASN E 119
LEU D  32
None
1.26A 4a83A-4p6vE:
undetectable
4a83A-4p6vE:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
5 / 12 LEU A 181
VAL A 175
GLY A 177
ALA A 176
LEU A 252
None
1.04A 4coxA-4p6vA:
undetectable
4coxA-4p6vA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
5 / 12 LEU A 181
VAL A 175
GLY A 177
ALA A 176
LEU A 252
None
1.06A 4coxB-4p6vA:
undetectable
4coxB-4p6vA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
5 / 12 LEU A 181
VAL A 175
GLY A 177
ALA A 176
LEU A 252
None
1.07A 4coxD-4p6vA:
undetectable
4coxD-4p6vA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae)
4 / 8 PRO C 174
ASN C 182
PRO C 183
ILE D  97
None
0.99A 4iilA-4p6vC:
undetectable
4iilA-4p6vC:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
4 / 7 ILE A 239
ASP A 179
LEU A 178
GLY A 177
None
0.80A 4iqqC-4p6vA:
undetectable
4iqqC-4p6vA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
5 / 9 ASP A  49
VAL A  51
PRO A  71
VAL A  72
ILE A  92
None
1.11A 4ll3B-4p6vA:
undetectable
4ll3B-4p6vA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
5 / 11 ASP B 346
VAL B  64
ALA B  63
GLY B 339
PHE B 338
None
None
None
FMN  B 600 ( 3.7A)
FMN  B 600 (-4.7A)
1.18A 4mm9A-4p6vB:
undetectable
4mm9A-4p6vB:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
5 / 12 GLY B 125
PHE B  69
ASN B  74
ALA B 228
TYR B 102
None
1.39A 4pclB-4p6vB:
undetectable
4pclB-4p6vB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
5 / 10 ALA F 286
ALA F 215
GLY F 281
GLY F 282
ALA F 283
FAD  F 502 ( 4.6A)
None
None
None
FAD  F 502 ( 4.0A)
0.93A 4qvpK-4p6vF:
undetectable
4qvpL-4p6vF:
undetectable
4qvpK-4p6vF:
21.62
4qvpL-4p6vF:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
5 / 10 ALA F 286
ALA F 215
GLY F 281
GLY F 282
ALA F 283
FAD  F 502 ( 4.6A)
None
None
None
FAD  F 502 ( 4.0A)
0.92A 4qvpY-4p6vF:
undetectable
4qvpZ-4p6vF:
undetectable
4qvpY-4p6vF:
21.62
4qvpZ-4p6vF:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
5 / 11 ALA F 286
ALA F 215
GLY F 281
GLY F 282
ALA F 283
FAD  F 502 ( 4.6A)
None
None
None
FAD  F 502 ( 4.0A)
0.94A 4qw1K-4p6vF:
undetectable
4qw1L-4p6vF:
undetectable
4qw1K-4p6vF:
21.87
4qw1L-4p6vF:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
5 / 10 ALA F 286
ALA F 215
GLY F 281
GLY F 282
ALA F 283
FAD  F 502 ( 4.6A)
None
None
None
FAD  F 502 ( 4.0A)
0.93A 4qw1Y-4p6vF:
undetectable
4qw1Z-4p6vF:
undetectable
4qw1Y-4p6vF:
21.87
4qw1Z-4p6vF:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
5 / 12 LEU A 181
VAL A 175
GLY A 177
ALA A 176
LEU A 252
None
1.06A 4rrwD-4p6vA:
undetectable
4rrwD-4p6vA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
5 / 12 LEU A 181
VAL A 175
GLY A 177
ALA A 176
LEU A 252
None
1.06A 4rrzD-4p6vA:
undetectable
4rrzD-4p6vA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
5 / 11 HIS A 320
GLY A 306
TYR A  36
TYR A 319
SER A 305
None
1.38A 4rv6A-4p6vA:
undetectable
4rv6A-4p6vA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
5 / 11 HIS A 320
GLY A 306
TYR A  36
TYR A 319
SER A 305
None
1.36A 4rv6B-4p6vA:
undetectable
4rv6B-4p6vA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
5 / 5 ARG F 229
GLY F 282
ALA F 283
GLY F 379
PRO F 380
None
None
FAD  F 502 ( 4.0A)
None
None
0.63A 4u9uA-4p6vF:
44.5
4u9uA-4p6vF:
87.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
4 / 5 ARG F 229
GLY F 282
GLY F 379
PRO F 380
None
0.77A 4u9uB-4p6vF:
44.2
4u9uB-4p6vF:
87.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
4 / 5 GLY F 282
ALA F 283
GLY F 379
PRO F 380
None
FAD  F 502 ( 4.0A)
None
None
0.16A 4u9uB-4p6vF:
44.2
4u9uB-4p6vF:
87.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae)
5 / 12 VAL D 114
LEU D 145
ALA D  31
LEU D 107
ASN D 111
None
1.22A 4x1kA-4p6vD:
undetectable
4x1kB-4p6vD:
undetectable
4x1kA-4p6vD:
20.14
4x1kB-4p6vD:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio
cholerae;
Vibrio
cholerae)
4 / 7 ARG C  34
PHE E  80
ASP D  87
ILE D  84
None
0.84A 5a06B-4p6vC:
undetectable
5a06B-4p6vC:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae)
4 / 6 ALA D  47
THR D  45
TYR D 141
VAL D  34
None
0.97A 5eckD-4p6vD:
undetectable
5eckD-4p6vD:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
5 / 12 ILE F 223
ARG F 289
CYH F 135
CYH F 258
LEU F 226
None
1.32A 5fhzD-4p6vF:
5.7
5fhzD-4p6vF:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae)
5 / 12 VAL D 105
ALA D  80
VAL D  83
SER D  30
ILE E 122
None
1.16A 5hv1A-4p6vD:
2.6
5hv1A-4p6vD:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio
cholerae)
5 / 12 ALA E 187
GLY E 189
ALA D 184
LEU D  32
SER E  20
None
1.35A 5jglB-4p6vE:
undetectable
5jglB-4p6vE:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
3 / 3 VAL F 160
SER F 159
TRP F 133
None
1.07A 5jwaA-4p6vF:
4.4
5jwaA-4p6vF:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
5 / 12 GLU A 389
GLY B 356
ASN B 354
ALA B 293
ASN A 379
None
1.33A 5kc4E-4p6vA:
undetectable
5kc4E-4p6vA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae)
4 / 5 ILE D 191
LEU D  16
GLY D 140
PHE D 143
None
0.76A 5kmdC-4p6vD:
undetectable
5kmdD-4p6vD:
1.6
5kmdC-4p6vD:
25.44
5kmdD-4p6vD:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae)
5 / 12 ARG D 152
GLY D 149
THR C 173
GLY C 177
GLY C 178
None
None
FMN  C 301 (-3.2A)
FMN  C 301 ( 3.8A)
None
0.93A 5koxA-4p6vD:
undetectable
5koxA-4p6vD:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae)
6 / 12 ASN E 119
GLY E  24
ALA E 121
GLY E 149
VAL E  48
ILE E 122
None
1.16A 5kqxA-4p6vE:
undetectable
5kqxA-4p6vE:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
4 / 8 ILE B 169
ALA B 205
ILE B 183
ALA B 179
None
0.72A 5mvmA-4p6vB:
undetectable
5mvmB-4p6vB:
undetectable
5mvmA-4p6vB:
14.94
5mvmB-4p6vB:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio
cholerae)
4 / 8 ILE C 137
VAL C  52
TYR C 167
THR C 166
None
0.95A 5mzrE-4p6vC:
undetectable
5mzrE-4p6vC:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae;
Vibrio
cholerae)
3 / 3 HIS A 234
SER A 231
ARG B 407
None
0.78A 5u63A-4p6vA:
2.8
5u63A-4p6vA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae)
5 / 12 PHE E 190
ALA E  18
SER E  11
PHE B 392
LEU B 395
None
1.46A 5uanB-4p6vE:
undetectable
5uanB-4p6vE:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio
cholerae)
4 / 8 SER C 103
ARG C 117
GLN C 110
ASN C 120
None
1.19A 5vunB-4p6vC:
undetectable
5vunB-4p6vC:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio
cholerae)
4 / 8 SER C 103
ARG C 117
GLN C 110
ASN C 120
None
1.23A 5vuoB-4p6vC:
undetectable
5vuoB-4p6vC:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
4 / 4 VAL A 123
LEU A 122
LEU A 127
ASP A 243
None
1.44A 5xv7A-4p6vA:
undetectable
5xv7A-4p6vA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio
cholerae)
4 / 8 SER C 103
ARG C 117
GLN C 110
ASN C 120
None
1.28A 6auuB-4p6vC:
undetectable
6auuB-4p6vC:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae)
5 / 12 ARG D 152
PHE D 104
PRO C 174
THR C 173
GLY C 177
None
None
None
FMN  C 301 (-3.2A)
FMN  C 301 ( 3.8A)
1.17A 6brdC-4p6vD:
undetectable
6brdC-4p6vD:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
3 / 3 ARG A 115
LYS A 119
ARG A 318
None
1.06A 6c06D-4p6vA:
undetectable
6c06D-4p6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
4 / 7 TYR F 212
CYH F 258
TYR F 248
LEU F 152
FAD  F 502 (-3.8A)
None
None
None
1.49A 6cnjA-4p6vF:
0.1
6cnjB-4p6vF:
0.0
6cnjA-4p6vF:
11.23
6cnjB-4p6vF:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
4 / 7 TYR F 212
CYH F 258
TYR F 248
LEU F 152
FAD  F 502 (-3.8A)
None
None
None
1.46A 6cnkB-4p6vF:
undetectable
6cnkC-4p6vF:
undetectable
6cnkB-4p6vF:
11.23
6cnkC-4p6vF:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio
cholerae)
5 / 12 ALA B 235
LEU B 249
VAL B 275
THR B 227
ALA B  82
None
1.16A 6djzC-4p6vB:
undetectable
6djzC-4p6vB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio
cholerae;
Vibrio
cholerae)
5 / 10 GLY E 184
ILE E 181
ALA E 183
THR E 179
GLY D 192
None
1.11A 6e5zA-4p6vE:
undetectable
6e5zA-4p6vE:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio
cholerae;
Vibrio
cholerae)
5 / 11 PHE D  58
ILE D  62
LEU D  61
LEU D  82
ILE C  24
None
1.31A 6fgcA-4p6vD:
undetectable
6fgcA-4p6vD:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio
cholerae)
5 / 11 SER A 238
TYR A 319
GLY A 301
SER A 324
ALA A 265
None
1.46A 6hu9A-4p6vA:
undetectable
6hu9E-4p6vA:
undetectable
6hu9I-4p6vA:
undetectable
6hu9A-4p6vA:
23.73
6hu9E-4p6vA:
17.37
6hu9I-4p6vA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
5 / 11 ALA F 286
ALA F 215
GLY F 281
GLY F 282
ALA F 283
FAD  F 502 ( 4.6A)
None
None
None
FAD  F 502 ( 4.0A)
0.88A 6hwdK-4p6vF:
undetectable
6hwdL-4p6vF:
undetectable
6hwdK-4p6vF:
11.30
6hwdL-4p6vF:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio
cholerae)
5 / 11 ALA F 286
ALA F 215
GLY F 281
GLY F 282
ALA F 283
FAD  F 502 ( 4.6A)
None
None
None
FAD  F 502 ( 4.0A)
0.88A 6hwdY-4p6vF:
undetectable
6hwdZ-4p6vF:
undetectable
6hwdY-4p6vF:
11.30
6hwdZ-4p6vF:
13.73