SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 7 GLY A 203
ASP A 220
SER A 194
HIS A  60
 None
 0.99A 1gxsA-4p6yA:
3.3
1gxsB-4p6yA:
undetectable		 1gxsA-4p6yA:
20.99
1gxsB-4p6yA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 8 ASP A 220
ILE A  64
GLY A  83
GLY A 280
 None
 0.74A 1me7A-4p6yA:
undetectable		 1me7A-4p6yA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 4 HIS A 234
ASP A 226
SER A 239
ASP A 223
 None
 1.32A 1n2xA-4p6yA:
undetectable		 1n2xA-4p6yA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 12 ILE A  95
ASP A 130
GLY A 106
LEU A  91
LEU A 127
 None
 1.05A 1rjdA-4p6yA:
undetectable		 1rjdA-4p6yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 12 ILE A  95
ASP A 130
GLY A 106
LEU A  91
LEU A 127
 None
 1.06A 1rjdB-4p6yA:
undetectable		 1rjdB-4p6yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 12 ILE A  95
ASP A 130
GLY A 106
LEU A  91
LEU A 127
 None
 1.08A 1rjdC-4p6yA:
undetectable		 1rjdC-4p6yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 11 HIS A 307
LEU A 201
GLU A 197
ILE A  64
GLU A 198
 None
 1.41A 1rnrA-4p6yA:
undetectable		 1rnrA-4p6yA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 6 ALA A 204
ASN A  43
ILE A  45
ASP A  39
 None
 1.02A 1yc2A-4p6yA:
undetectable		 1yc2A-4p6yA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 5 ALA A 204
ASN A  43
ILE A  45
ASP A  39
 None
 0.92A 1yc2D-4p6yA:
undetectable		 1yc2D-4p6yA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 12 TYR A 287
SER A 194
ASN A  43
GLY A 191
ILE A  56
 None
 1.31A 2dcfA-4p6yA:
undetectable		 2dcfA-4p6yA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 11 TYR A 287
SER A 194
ASN A  43
GLY A 191
ILE A  56
 None
 1.31A 2zmaA-4p6yA:
undetectable		 2zmaA-4p6yA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 12 TYR A 287
SER A 194
ASN A  43
GLY A 191
ILE A  56
 None
 1.24A 3a65A-4p6yA:
undetectable		 3a65A-4p6yA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 6 VAL A 179
MET A   1
ILE A 217
ILE A 176
 None
 0.92A 3gcsA-4p6yA:
undetectable		 3gcsA-4p6yA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 5 ARG A  37
LEU A  26
ILE A 176
PHE A 193
 None
 1.24A 3ln1D-4p6yA:
undetectable		 3ln1D-4p6yA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 11 ALA A  59
ILE A  25
ILE A   5
VAL A 179
ILE A 176
 None
 1.03A 3lzvB-4p6yA:
undetectable		 3lzvB-4p6yA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 12 VAL A  82
PHE A 148
GLY A  65
VAL A 150
ARG A  17
 None
 1.31A 4bvaB-4p6yA:
undetectable		 4bvaB-4p6yA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		6 / 11 HIS A  60
ASP A 168
GLU A 197
GLU A 198
GLY A 280
HIS A 307
 None
 0.72A 4pqaA-4p6yA:
23.8		 4pqaA-4p6yA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 12 ILE A  61
GLY A 172
ILE A 219
ILE A  33
ASP A  58
 None
 1.03A 5e72A-4p6yA:
undetectable		 5e72A-4p6yA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 11 VAL A 299
SER A 300
ASP A 220
THR A 222
LEU A 261
 None
 1.30A 5jh7B-4p6yA:
undetectable		 5jh7B-4p6yA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 11 VAL A 299
SER A 300
ASP A 220
THR A 222
LEU A 261
 None
 1.26A 5jh7D-4p6yA:
3.1		 5jh7D-4p6yA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		5 / 9 ALA A  59
ILE A  25
ILE A   5
VAL A 179
ILE A 176
 None
 1.12A 5kr0A-4p6yA:
undetectable		 5kr0A-4p6yA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		4 / 5 TYR A 305
MET A 312
THR A 303
LEU A 238
 None
 1.44A 5x1bW-4p6yA:
undetectable		 5x1bW-4p6yA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 4p6y AMINOPEPTIDASE
(Thermotoga
maritima) 		3 / 3 ARG A  96
PHE A  97
GLY A 100
 None
 0.80A 6fgdA-4p6yA:
3.8		 6fgdA-4p6yA:
22.55