SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p79'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p79 CLAUDIN-15
(Mus
musculus) 		4 / 5 GLU A  46
TYR A 156
PHE A  65
PRO A  66
 None
 1.32A 1dfoB-4p79A:
undetectable		 1dfoB-4p79A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p79 CLAUDIN-15
(Mus
musculus) 		4 / 5 GLU A  46
TYR A 156
PHE A  65
PRO A  66
 None
 1.33A 1dfoA-4p79A:
undetectable		 1dfoA-4p79A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p79 CLAUDIN-15
(Mus
musculus) 		4 / 5 GLU A  46
TYR A 156
PHE A  65
PRO A  66
 None
 1.33A 1dfoD-4p79A:
undetectable		 1dfoD-4p79A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p79 CLAUDIN-15
(Mus
musculus) 		4 / 5 GLU A  46
TYR A 156
PHE A  65
PRO A  66
 None
 1.33A 1dfoC-4p79A:
undetectable		 1dfoC-4p79A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 4p79 CLAUDIN-15
(Mus
musculus) 		3 / 3 MET A  68
LEU A  71
SER A  72
 None
 0.48A 1ee2A-4p79A:
undetectable		 1ee2A-4p79A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4p79 CLAUDIN-15
(Mus
musculus) 		4 / 4 HIS A 124
ALA A 120
PHE A 180
GLY A 176
 None
 1.34A 1mj2B-4p79A:
undetectable		 1mj2B-4p79A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4p79 CLAUDIN-15
(Mus
musculus) 		4 / 4 HIS A 124
ALA A 120
PHE A 180
GLY A 176
 None
 1.35A 1mj2D-4p79A:
undetectable		 1mj2D-4p79A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4p79 CLAUDIN-15
(Mus
musculus) 		4 / 4 HIS A 124
ALA A 120
PHE A 180
GLY A 176
 None
 1.35A 1mjoB-4p79A:
undetectable		 1mjoB-4p79A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4p79 CLAUDIN-15
(Mus
musculus) 		4 / 4 HIS A 124
ALA A 120
PHE A 180
GLY A 176
 None
 1.38A 1mjoA-4p79A:
undetectable		 1mjoA-4p79A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4p79 CLAUDIN-15
(Mus
musculus) 		4 / 4 HIS A 124
ALA A 120
PHE A 180
GLY A 176
 None
 1.35A 1mjoD-4p79A:
undetectable		 1mjoD-4p79A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 4p79 CLAUDIN-15
(Mus
musculus) 		5 / 12 ALA A 127
GLY A 131
ILE A  86
ILE A 173
SER A 172
 None
None
OLC  A 201 ( 4.5A)
None
None
 1.05A 1ve3A-4p79A:
undetectable		 1ve3A-4p79A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p79 CLAUDIN-15
(Mus
musculus) 		4 / 6 GLU A  46
TYR A 156
PHE A  65
PRO A  66
 None
 1.49A 2vmyA-4p79A:
undetectable		 2vmyA-4p79A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 4p79 CLAUDIN-15
(Mus
musculus) 		3 / 3 PHE A  45
TYR A  50
LEU A 158
 None
OLC  A 201 (-4.3A)
None
 0.73A 3keeB-4p79A:
undetectable		 3keeB-4p79A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4p79 CLAUDIN-15
(Mus
musculus) 		3 / 3 PHE A  45
TYR A  50
LEU A 158
 None
OLC  A 201 (-4.3A)
None
 0.65A 3sueB-4p79A:
undetectable		 3sueB-4p79A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 4p79 CLAUDIN-15
(Mus
musculus) 		5 / 12 THR A  23
GLY A 131
GLY A 165
ALA A 168
GLY A 128
 None
 0.88A 3tegA-4p79A:
undetectable		 3tegA-4p79A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4p79 CLAUDIN-15
(Mus
musculus) 		3 / 3 LEU A  20
LEU A  24
TRP A  49
 None
OLC  A 201 (-4.0A)
OLC  A 201 (-4.2A)
 0.88A 5nwuA-4p79A:
undetectable		 5nwuA-4p79A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4p79 CLAUDIN-15
(Mus
musculus) 		5 / 12 LEU A 171
LEU A 174
GLY A 175
GLY A 176
VAL A 179
 None
 0.82A 5uc1A-4p79A:
undetectable		 5uc1A-4p79A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4p79 CLAUDIN-15
(Mus
musculus) 		5 / 12 LEU A 171
LEU A 174
GLY A 175
GLY A 176
VAL A 179
 None
 0.82A 5uc1B-4p79A:
undetectable		 5uc1B-4p79A:
20.97