SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p7c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 LEU A  51
VAL A  96
GLY A  95
TYR A 163
 None
 0.95A 1lweA-4p7cA:
undetectable		 1lweA-4p7cA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 4 ILE A 202
ASP A 210
LEU A 218
ARG A 260
 None
 1.40A 2a7qA-4p7cA:
undetectable		 2a7qA-4p7cA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 ARG A 135
VAL A 111
LEU A 115
ALA A 139
 None
 1.02A 2e1qA-4p7cA:
undetectable		 2e1qA-4p7cA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ALA A  79
ALA A  44
LEU A  48
ALA A  47
LEU A 152
 None
 0.99A 3h0aA-4p7cA:
undetectable		 3h0aA-4p7cA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 ASP A 187
GLY A 185
VAL A 213
THR A  14
 None
 1.09A 3vqrA-4p7cA:
undetectable		 3vqrA-4p7cA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 ASP A 187
GLY A 185
VAL A 213
THR A  14
 None
 1.10A 3vqrB-4p7cA:
undetectable		 3vqrB-4p7cA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 THR A 188
VAL A 144
ASP A 124
VAL A 122
 None
 1.00A 4cp4A-4p7cA:
undetectable		 4cp4A-4p7cA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ARG A 103
PRO A  90
ASN A  92
 BTB  A 401 (-3.3A)
BTB  A 401 (-4.6A)
BTB  A 401 (-3.1A)
 1.02A 5jwaA-4p7cA:
2.0
5jwaH-4p7cA:
2.4		 5jwaA-4p7cA:
19.18
5jwaH-4p7cA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 PHE A 174
LEU A 183
VAL A 125
GLY A 146
LEU A  27
 None
None
ACT  A 403 ( 4.9A)
None
None
 1.15A 5x24A-4p7cA:
undetectable		 5x24A-4p7cA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 SER A 104
TYR A 132
GLN A 279
GLU A 221
 None
None
ACT  A 402 (-3.1A)
None
 1.20A 6djzA-4p7cA:
undetectable		 6djzA-4p7cA:
22.77