SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		3 / 3 PHE A 356
TYR A 432
PRO A 402
 None
 0.94A 1mcnA-4p7lA:
undetectable
1mcnB-4p7lA:
undetectable
1mcnP-4p7lA:
undetectable		 1mcnA-4p7lA:
20.66
1mcnB-4p7lA:
20.66
1mcnP-4p7lA:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		5 / 11 PHE A 553
ASP A 466
ILE A 545
PHE A 560
GLU A 576
 None
 1.40A 3ko0A-4p7lA:
undetectable
3ko0B-4p7lA:
undetectable
3ko0C-4p7lA:
undetectable
3ko0D-4p7lA:
undetectable		 3ko0A-4p7lA:
15.25
3ko0B-4p7lA:
15.25
3ko0C-4p7lA:
15.25
3ko0D-4p7lA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		5 / 11 ASP A 466
PHE A 553
GLU A 576
ILE A 545
PHE A 560
 None
 1.31A 3ko0Q-4p7lA:
undetectable
3ko0R-4p7lA:
undetectable
3ko0S-4p7lA:
undetectable
3ko0T-4p7lA:
undetectable		 3ko0Q-4p7lA:
15.25
3ko0R-4p7lA:
15.25
3ko0S-4p7lA:
15.25
3ko0T-4p7lA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		3 / 3 PHE A 503
LYS A 510
SER A 511
 None
 1.30A 3tyeB-4p7lA:
8.1		 3tyeB-4p7lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		5 / 12 LEU A 650
VAL A 324
ALA A 610
LEU A 353
VAL A 351
 None
 1.22A 4ib4A-4p7lA:
undetectable		 4ib4A-4p7lA:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P7N_A_GCSA701_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		5 / 5 TYR A 432
ASP A 466
MET A 572
TRP A 613
TYR A 645
 None
 0.27A 4p7nA-4p7lA:
60.7		 4p7nA-4p7lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		3 / 3 ASP A 467
TYR A 432
TRP A 406
 None
 1.35A 4p7nA-4p7lA:
60.7		 4p7nA-4p7lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		3 / 3 ASP A 472
TYR A 473
TRP A 552
 None
 0.47A 4p7nA-4p7lA:
60.7		 4p7nA-4p7lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P7N_A_GCSA703_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		4 / 4 LEU A 542
PHE A 553
LEU A 575
GLU A 576
 None
 0.14A 4p7nA-4p7lA:
60.7		 4p7nA-4p7lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		5 / 12 ILE A 462
ALA A 454
VAL A 442
LEU A 521
LEU A 375
 None
 1.02A 4qynA-4p7lA:
undetectable		 4qynA-4p7lA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		4 / 6 ARG A 315
ILE A 605
GLN A 314
ILE A 348
 None
 1.12A 4w5tA-4p7lA:
2.5		 4w5tA-4p7lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		4 / 6 ARG A 315
ILE A 605
GLN A 314
ILE A 348
 None
 1.15A 4z4cA-4p7lA:
1.7		 4z4cA-4p7lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		4 / 6 ARG A 315
ILE A 605
GLN A 314
ILE A 348
 None
 1.16A 4z4dA-4p7lA:
2.1		 4z4dA-4p7lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		3 / 3 TRP A 387
ILE A 340
SER A 393
 None
 0.87A 5gqbA-4p7lA:
17.0		 5gqbA-4p7lA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		4 / 8 LEU A 650
LEU A 339
TYR A 325
GLN A 330
 None
 0.99A 5hbsA-4p7lA:
undetectable		 5hbsA-4p7lA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		4 / 4 GLU A 655
PRO A 654
ILE A 659
LEU A 658
 None
 1.34A 5m45D-4p7lA:
undetectable		 5m45D-4p7lA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		4 / 4 GLU A 655
PRO A 654
ILE A 659
LEU A 658
 None
 1.31A 5m45G-4p7lA:
undetectable		 5m45G-4p7lA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		4 / 4 GLY A 461
ASP A 460
ARG A 529
MET A 377
 None
 1.49A 5zrfA-4p7lA:
undetectable		 5zrfA-4p7lA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Escherichia
coli) 		4 / 6 ARG A 315
ILE A 605
GLN A 314
ILE A 348
 None
 1.19A 6cbdA-4p7lA:
undetectable		 6cbdA-4p7lA:
18.10