SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 8 GLU A 247
ARG A 250
ARG A 251
GLU A 206
 None
 0.63A 1cmaA-4p7wA:
undetectable
1cmaB-4p7wA:
undetectable		 1cmaA-4p7wA:
19.52
1cmaB-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 8 GLU A 247
ARG A 250
LEU A 209
GLU A 206
 None
 0.99A 1cmaA-4p7wA:
undetectable
1cmaB-4p7wA:
undetectable		 1cmaA-4p7wA:
19.52
1cmaB-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		5 / 11 GLU A 247
ARG A 250
ARG A 251
LEU A 209
GLU A 206
 None
 0.87A 1cmaA-4p7wA:
undetectable
1cmaB-4p7wA:
undetectable		 1cmaA-4p7wA:
19.52
1cmaB-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		5 / 10 GLU A 247
ARG A 250
ARG A 251
LEU A 209
GLU A 206
 None
 0.83A 1cmcA-4p7wA:
undetectable
1cmcB-4p7wA:
undetectable		 1cmcA-4p7wA:
19.52
1cmcB-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		3 / 3 GLN A  48
HIS A  60
PRO A  63
 None
 0.59A 1d8cA-4p7wA:
undetectable		 1d8cA-4p7wA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		3 / 3 ARG A  93
ARG A  56
ARG A 118
 PRO  A 303 (-2.5A)
None
PRO  A 303 ( 2.9A)
 0.80A 1l7fA-4p7wA:
undetectable		 1l7fA-4p7wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		3 / 3 ARG A  93
ARG A  56
ARG A 118
 PRO  A 303 (-2.5A)
None
PRO  A 303 ( 2.9A)
 0.81A 1l7hA-4p7wA:
undetectable		 1l7hA-4p7wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		5 / 12 GLU A 247
ARG A 250
ARG A 251
LEU A 209
GLU A 206
 None
 0.82A 1mj2A-4p7wA:
undetectable
1mj2B-4p7wA:
undetectable		 1mj2A-4p7wA:
19.52
1mj2B-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		5 / 9 GLU A 247
ARG A 250
ARG A 251
LEU A 209
GLU A 206
 None
 0.82A 1mj2A-4p7wA:
undetectable		 1mj2A-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		5 / 9 GLU A 247
ARG A 250
ARG A 251
LEU A 209
GLU A 206
 None
 0.85A 1mj2C-4p7wA:
undetectable		 1mj2C-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		5 / 12 GLU A 247
ARG A 250
ARG A 251
LEU A 209
GLU A 206
 None
 0.79A 1mj2C-4p7wA:
undetectable
1mj2D-4p7wA:
undetectable		 1mj2C-4p7wA:
19.52
1mj2D-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		5 / 11 GLU A 247
ARG A 250
ARG A 251
LEU A 209
GLU A 206
 None
 0.84A 1mjlA-4p7wA:
undetectable
1mjlB-4p7wA:
undetectable		 1mjlA-4p7wA:
19.52
1mjlB-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		5 / 9 GLU A 247
ARG A 250
ARG A 251
LEU A 209
GLU A 206
 None
 0.81A 1mjoA-4p7wA:
undetectable		 1mjoA-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		5 / 9 GLU A 247
ARG A 250
ARG A 251
LEU A 209
GLU A 206
 None
 0.80A 1mjoB-4p7wA:
undetectable		 1mjoB-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		5 / 12 GLU A 247
ARG A 250
ARG A 251
LEU A 209
GLU A 206
 None
 0.81A 1mjoC-4p7wA:
undetectable
1mjoD-4p7wA:
undetectable		 1mjoC-4p7wA:
19.52
1mjoD-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		5 / 9 GLU A 247
ARG A 250
ARG A 251
LEU A 209
GLU A 206
 None
 0.82A 1mjoC-4p7wA:
undetectable		 1mjoC-4p7wA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 8 HIS A 234
VAL A 236
LEU A 205
THR A 204
 None
 0.89A 2it4A-4p7wA:
undetectable		 2it4A-4p7wA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		3 / 3 ASP A  19
LEU A  23
GLN A  52
 None
 0.78A 3g4lA-4p7wA:
undetectable		 3g4lA-4p7wA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 6 ILE A 145
VAL A   9
LEU A  11
LEU A 123
 None
 0.90A 3kp6A-4p7wA:
undetectable
3kp6B-4p7wA:
undetectable		 3kp6A-4p7wA:
23.27
3kp6B-4p7wA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		3 / 3 LEU A 148
TRP A 146
GLY A 141
 None
 0.70A 3l35A-4p7wA:
undetectable
3l35H-4p7wA:
undetectable		 3l35A-4p7wA:
11.67
3l35H-4p7wA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		3 / 3 LEU A 148
TRP A 146
GLY A 141
 None
 0.74A 3l35B-4p7wA:
undetectable
3l35K-4p7wA:
undetectable		 3l35B-4p7wA:
11.67
3l35K-4p7wA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 8 GLU A 111
ARG A 272
ASP A  34
PHE A  35
 None
None
None
PRO  A 303 (-3.5A)
 1.09A 3mjrD-4p7wA:
undetectable		 3mjrD-4p7wA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 6 VAL A 224
ASN A 219
TYR A 220
ILE A 248
 None
 1.18A 3q5sA-4p7wA:
undetectable		 3q5sA-4p7wA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		3 / 3 TYR A 109
ARG A 272
HIS A 106
 None
None
CO  A 301 ( 3.3A)
 1.06A 4fubA-4p7wA:
undetectable		 4fubA-4p7wA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		3 / 3 HIS A 231
TRP A 200
SER A 155
 None
 1.01A 4lrhD-4p7wA:
undetectable		 4lrhD-4p7wA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 8 SER A 155
HIS A 106
ILE A  97
TRP A  40
 None
CO  A 301 ( 3.3A)
None
AKG  A 302 (-4.2A)
 1.09A 4ms4A-4p7wA:
undetectable		 4ms4A-4p7wA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 7 THR A 193
PHE A 138
SER A 130
HIS A 139
 None
 1.47A 4o4dA-4p7wA:
undetectable		 4o4dA-4p7wA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		3 / 3 ASP A  85
ARG A  90
PRO A  63
 None
 1.09A 4wanC-4p7wA:
undetectable		 4wanC-4p7wA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 6 GLY A  50
THR A  67
GLY A  70
ASN A  47
 None
 0.77A 5k4pA-4p7wA:
undetectable		 5k4pA-4p7wA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 6 HIS A 234
VAL A 236
LEU A 205
THR A 204
 None
 0.88A 5ogjA-4p7wA:
undetectable		 5ogjA-4p7wA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 6 HIS A 234
VAL A 236
LEU A 205
THR A 204
 None
 0.86A 5ogjB-4p7wA:
undetectable		 5ogjB-4p7wA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 5 HIS A 234
VAL A 236
LEU A 205
THR A 204
 None
 0.86A 5ohhA-4p7wA:
undetectable		 5ohhA-4p7wA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 6 HIS A 234
VAL A 236
LEU A 205
THR A 204
 None
 0.87A 5ohhB-4p7wA:
undetectable		 5ohhB-4p7wA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 4p7w L-PROLINE
CIS-4-HYDROXYLASE
(Mesorhizobium
japonicum) 		4 / 5 HIS A 106
ASP A 108
HIS A 154
ARG A 118
 CO  A 301 ( 3.3A)
CO  A 301 (-2.5A)
CO  A 301 ( 3.3A)
PRO  A 303 ( 2.9A)
 0.74A 6dchA-4p7wA:
4.2		 6dchA-4p7wA:
21.05