SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 8 CYH A 193
CYH A 269
GLY A 311
GLY A 310
TYR A 211
 None
 1.48A 1ekjA-4p7yA:
undetectable
1ekjB-4p7yA:
undetectable		 1ekjA-4p7yA:
20.45
1ekjB-4p7yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 8 CYH A 193
CYH A 269
GLY A 311
GLY A 310
TYR A 211
 None
 1.48A 1ekjG-4p7yA:
undetectable
1ekjH-4p7yA:
undetectable		 1ekjG-4p7yA:
20.45
1ekjH-4p7yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 10 LEU A 279
GLY A 320
GLY A 371
VAL A 288
ILE A 285
 None
 0.95A 1sdtA-4p7yA:
undetectable		 1sdtA-4p7yA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 7 ARG A 234
TYR A  56
ASP A  67
GLU A  70
 None
 1.08A 2qebA-4p7yA:
undetectable		 2qebA-4p7yA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 7 ARG A 234
TYR A  56
ASP A  67
GLU A  70
 None
 1.09A 2qebB-4p7yA:
undetectable		 2qebB-4p7yA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		3 / 3 PHE A  32
ASN A  63
PHE A  37
 None
 0.94A 2zbuD-4p7yA:
undetectable		 2zbuD-4p7yA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 5 VAL A 204
GLN A 195
PHE A 188
ARG A  78
 None
1PE  A 402 (-4.0A)
None
None
 1.43A 3bjwE-4p7yA:
undetectable		 3bjwE-4p7yA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 4 THR A  94
VAL A 205
GLY A 220
THR A 209
 None
None
LLP  A 210 ( 4.8A)
LLP  A 210 ( 3.4A)
 1.04A 3cflA-4p7yA:
undetectable		 3cflA-4p7yA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		3 / 3 LEU A 301
GLU A 169
ILE A 168
 None
 0.60A 3czhA-4p7yA:
undetectable		 3czhA-4p7yA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 11 GLY A 244
ILE A 222
VAL A 208
GLY A  88
ILE A  89
 None
None
None
LLP  A 210 ( 3.5A)
LLP  A 210 ( 4.3A)
 1.04A 3ebzB-4p7yA:
undetectable		 3ebzB-4p7yA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		3 / 3 ILE A 129
SER A 123
SER A 121
 None
 0.58A 3iltH-4p7yA:
undetectable		 3iltH-4p7yA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 6 GLY A  82
GLN A 227
ILE A 223
VAL A 224
 None
 1.12A 3kvvA-4p7yA:
undetectable		 3kvvA-4p7yA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 6 GLY A  82
GLN A 227
ILE A 223
VAL A 224
 None
 1.10A 3kvvB-4p7yA:
undetectable		 3kvvB-4p7yA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 6 GLY A  82
GLN A 227
ILE A 223
VAL A 224
 None
 1.12A 3kvvC-4p7yA:
undetectable		 3kvvC-4p7yA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 6 GLY A  82
GLN A 227
ILE A 223
VAL A 224
 None
 1.11A 3kvvD-4p7yA:
undetectable		 3kvvD-4p7yA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 6 GLY A  82
GLN A 227
ILE A 223
VAL A 224
 None
 1.12A 3kvvE-4p7yA:
undetectable		 3kvvE-4p7yA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 6 GLY A  82
GLN A 227
ILE A 223
VAL A 224
 None
 1.12A 3kvvF-4p7yA:
undetectable		 3kvvF-4p7yA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 9 GLY A 200
ALA A 201
ASP A 202
ILE A 203
ILE A 174
 None
 0.77A 3ogpB-4p7yA:
undetectable		 3ogpB-4p7yA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 11 GLY A 200
ALA A 201
ASP A 202
VAL A 152
ILE A 174
 None
 0.90A 3ufnA-4p7yA:
undetectable		 3ufnA-4p7yA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 7 ALA A 109
ALA A 137
ALA A 159
THR A 157
 None
 0.89A 4du2A-4p7yA:
undetectable		 4du2A-4p7yA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 7 ALA A 109
ALA A 137
ALA A 159
THR A 157
 None
 0.85A 4du2B-4p7yA:
undetectable		 4du2B-4p7yA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 6 GLY A  82
GLN A 227
ILE A 223
VAL A 224
 None
 1.15A 4e1vF-4p7yA:
undetectable		 4e1vF-4p7yA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 10 LEU A 181
VAL A 183
LEU A  99
THR A  98
VAL A 152
 None
 0.91A 4e3hA-4p7yA:
undetectable		 4e3hA-4p7yA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 9 VAL A 184
VAL A 183
VAL A 166
ILE A 168
GLY A 200
 None
 1.13A 4fwdA-4p7yA:
undetectable		 4fwdA-4p7yA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 12 PRO A 309
GLY A 310
LEU A 301
ASP A 167
LEU A 199
 None
 1.05A 4fzvA-4p7yA:
undetectable		 4fzvA-4p7yA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 8 SER A  90
ALA A 233
LEU A  83
PHE A  39
 None
 0.96A 4rkuA-4p7yA:
undetectable
4rkuJ-4p7yA:
undetectable		 4rkuA-4p7yA:
20.44
4rkuJ-4p7yA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 12 ILE A 203
ILE A 223
VAL A 183
GLU A 156
ILE A  92
 None
None
None
LLP  A 210 ( 3.7A)
None
 1.12A 5lg3J-4p7yA:
undetectable		 5lg3J-4p7yA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 12 ILE A  89
LEU A  96
GLU A 156
TYR A 154
PHE A 133
 LLP  A 210 ( 4.3A)
None
LLP  A 210 ( 3.7A)
None
None
 1.13A 5uxdB-4p7yA:
undetectable		 5uxdB-4p7yA:
24.20