SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p80'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 4p80 ANCESTRAL PYRR
PROTEIN (GREEN)
(synthetic
construct) 		5 / 10 ASP A   9
ILE A  13
GLY A 150
ILE A 149
VAL A 161
 None
 0.92A 3nu6A-4p80A:
undetectable		 3nu6A-4p80A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 4p80 ANCESTRAL PYRR
PROTEIN (GREEN)
(synthetic
construct) 		5 / 10 ASP A   9
ILE A  13
GLY A 150
ILE A 149
VAL A 161
 None
 0.94A 3nujA-4p80A:
undetectable		 3nujA-4p80A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 4p80 ANCESTRAL PYRR
PROTEIN (GREEN)
(synthetic
construct) 		5 / 9 ASP A   9
ILE A  13
GLY A 150
ILE A 149
VAL A 161
 None
 0.92A 3nuoA-4p80A:
undetectable		 3nuoA-4p80A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4p80 ANCESTRAL PYRR
PROTEIN (GREEN)
(synthetic
construct) 		4 / 5 ALA A 132
HIS A  22
MET A  24
ARG A  19
 None
 1.21A 4ac9B-4p80A:
3.0
4ac9C-4p80A:
3.3		 4ac9B-4p80A:
19.41
4ac9C-4p80A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 4p80 ANCESTRAL PYRR
PROTEIN (GREEN)
(synthetic
construct) 		5 / 12 ASP A   9
ILE A  13
GLY A 150
ILE A 149
VAL A 161
 None
 0.96A 4dqfA-4p80A:
undetectable		 4dqfA-4p80A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4p80 ANCESTRAL PYRR
PROTEIN (GREEN)
(synthetic
construct) 		4 / 7 GLU A  23
ILE A 101
ILE A  54
MET A  31
 None
 0.89A 4xumA-4p80A:
undetectable		 4xumA-4p80A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4p80 ANCESTRAL PYRR
PROTEIN (GREEN)
(synthetic
construct) 		5 / 10 LEU A 102
ILE A  39
GLY A  38
GLY A  65
ALA A 116
 None
 1.07A 5o96C-4p80A:
undetectable
5o96D-4p80A:
undetectable		 5o96C-4p80A:
23.51
5o96D-4p80A:
23.51