SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 4p81 ANCESTRAL PYRR
PROTEIN (ORANGE)
(synthetic
construct) 		5 / 12 ILE A  45
ALA A  48
THR A 113
LEU A  68
LEU A  72
 None
None
SO4  A 201 (-3.6A)
None
None
 1.16A 1og5B-4p81A:
undetectable		 1og5B-4p81A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4p81 ANCESTRAL PYRR
PROTEIN (ORANGE)
(synthetic
construct) 		4 / 5 GLY A  39
PRO A  93
VAL A  94
ILE A  96
 None
 0.84A 2aoiA-4p81A:
undetectable		 2aoiA-4p81A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 4p81 ANCESTRAL PYRR
PROTEIN (ORANGE)
(synthetic
construct) 		4 / 5 LEU A   9
ILE A 162
ILE A  14
GLY A 151
 None
 0.93A 3bufA-4p81A:
undetectable		 3bufA-4p81A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4p81 ANCESTRAL PYRR
PROTEIN (ORANGE)
(synthetic
construct) 		5 / 12 LEU A 132
LEU A 121
LEU A  68
ILE A  40
ILE A 145
 None
 0.99A 4odrA-4p81A:
undetectable
4odrB-4p81A:
undetectable		 4odrA-4p81A:
19.25
4odrB-4p81A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4p81 ANCESTRAL PYRR
PROTEIN (ORANGE)
(synthetic
construct) 		4 / 7 ALA A  22
TYR A 149
GLU A  27
HIS A  23
 None
 1.10A 5ecnA-4p81A:
1.6		 5ecnA-4p81A:
15.62