SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 LEU A  39
LEU A 278
GLY A  48
LEU A 244
 X2X  A 403 ( 4.5A)
None
None
None
 0.90A 1gtiB-4p8bA:
undetectable		 1gtiB-4p8bA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		3 / 3 VAL A 144
TRP A 253
VAL A 248
 None
 0.93A 2izqA-4p8bA:
undetectable
2izqB-4p8bA:
undetectable		 2izqA-4p8bA:
8.12
2izqB-4p8bA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		5 / 12 VAL A 144
THR A  80
ASN A 100
GLY A  96
ALA A  94
 None
None
X2X  A 403 (-3.2A)
None
None
 1.21A 2x2iA-4p8bA:
undetectable		 2x2iA-4p8bA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		5 / 12 VAL A 144
THR A  80
ASN A 100
GLY A  96
ALA A  94
 None
None
X2X  A 403 (-3.2A)
None
None
 1.16A 2x2iC-4p8bA:
undetectable		 2x2iC-4p8bA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 SER A  36
VAL A 247
ILE A  91
TRP A 101
 None
 1.05A 2x45B-4p8bA:
undetectable		 2x45B-4p8bA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 SER A  36
VAL A 247
ILE A  91
TRP A 101
 None
 1.06A 2x45C-4p8bA:
undetectable		 2x45C-4p8bA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		5 / 11 ILE A 245
PHE A 111
GLY A 132
PRO A 146
ILE A 135
 None
 1.36A 2y7kA-4p8bA:
8.3		 2y7kA-4p8bA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 3jwtA-4p8bA:
0.7
3jwtB-4p8bA:
undetectable		 3jwtA-4p8bA:
20.81
3jwtB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 3jwuA-4p8bA:
undetectable
3jwuB-4p8bA:
undetectable		 3jwuA-4p8bA:
20.81
3jwuB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		5 / 9 GLY A  46
ILE A 276
PHE A 136
PHE A 246
GLY A  96
 None
 0.94A 3ko0A-4p8bA:
undetectable
3ko0C-4p8bA:
undetectable		 3ko0A-4p8bA:
15.50
3ko0C-4p8bA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		5 / 9 PHE A 246
GLY A  96
GLY A  46
ILE A 276
PHE A 136
 None
 0.84A 3ko0H-4p8bA:
undetectable
3ko0I-4p8bA:
undetectable		 3ko0H-4p8bA:
15.50
3ko0I-4p8bA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 8 GLY A  46
ILE A 276
PHE A 136
PHE A 246
 None
 0.81A 3ko0K-4p8bA:
undetectable
3ko0S-4p8bA:
undetectable		 3ko0K-4p8bA:
15.50
3ko0S-4p8bA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		5 / 10 PHE A 246
GLY A  96
GLY A  46
ILE A 276
PHE A 136
 None
 0.91A 3ko0L-4p8bA:
undetectable
3ko0N-4p8bA:
undetectable		 3ko0L-4p8bA:
15.50
3ko0N-4p8bA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 PHE A 246
GLY A  96
GLY A  46
PHE A 136
 None
 0.67A 3ko0M-4p8bA:
undetectable
3ko0P-4p8bA:
undetectable		 3ko0M-4p8bA:
15.50
3ko0P-4p8bA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		5 / 10 GLY A  46
ILE A 276
PHE A 136
PHE A 246
GLY A  96
 None
 0.94A 3ko0R-4p8bA:
undetectable
3ko0T-4p8bA:
undetectable		 3ko0R-4p8bA:
15.50
3ko0T-4p8bA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.50A 3nlkA-4p8bA:
undetectable
3nlkB-4p8bA:
undetectable		 3nlkA-4p8bA:
20.81
3nlkB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.50A 3nlnA-4p8bA:
undetectable
3nlnB-4p8bA:
undetectable		 3nlnA-4p8bA:
20.81
3nlnB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.48A 3nlnA-4p8bA:
undetectable
3nlnB-4p8bA:
undetectable		 3nlnA-4p8bA:
20.81
3nlnB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.50A 3ufqA-4p8bA:
undetectable
3ufqB-4p8bA:
0.7		 3ufqA-4p8bA:
20.81
3ufqB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.33A 3ufrA-4p8bA:
undetectable
3ufrB-4p8bA:
undetectable		 3ufrA-4p8bA:
20.81
3ufrB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.50A 3uftA-4p8bA:
undetectable
3uftB-4p8bA:
undetectable		 3uftA-4p8bA:
20.81
3uftB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.44A 3uftA-4p8bA:
undetectable
3uftB-4p8bA:
undetectable		 3uftA-4p8bA:
20.81
3uftB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.47A 4ctrA-4p8bA:
undetectable
4ctrB-4p8bA:
undetectable		 4ctrA-4p8bA:
20.81
4ctrB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.50A 4cttA-4p8bA:
undetectable
4cttB-4p8bA:
undetectable		 4cttA-4p8bA:
20.81
4cttB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMW_A_H4BA805_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.44A 4imwA-4p8bA:
undetectable
4imwB-4p8bA:
undetectable		 4imwA-4p8bA:
20.81
4imwB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 4k5fA-4p8bA:
undetectable
4k5fB-4p8bA:
undetectable		 4k5fA-4p8bA:
20.81
4k5fB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.47A 4kckA-4p8bA:
undetectable
4kckB-4p8bA:
undetectable		 4kckA-4p8bA:
20.81
4kckB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 ARG A 165
ASP A 212
GLY A 230
THR A 235
 None
 1.08A 4l1aB-4p8bA:
undetectable		 4l1aB-4p8bA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 PHE A 312
ASP A 169
LEU A 170
THR A 235
 None
 1.29A 4paeA-4p8bA:
undetectable		 4paeA-4p8bA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		5 / 11 GLY A  46
MET A  35
GLN A 274
ILE A  51
PHE A 246
 None
 1.14A 4qoiA-4p8bA:
3.0
4qoiB-4p8bA:
undetectable		 4qoiA-4p8bA:
22.25
4qoiB-4p8bA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 4uh0A-4p8bA:
undetectable
4uh0B-4p8bA:
undetectable		 4uh0A-4p8bA:
20.81
4uh0B-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		5 / 11 GLY A 213
LEU A 175
GLU A 215
GLN A 214
PHE A 187
 None
 1.09A 4wnuC-4p8bA:
undetectable		 4wnuC-4p8bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5ad6A-4p8bA:
undetectable
5ad6B-4p8bA:
undetectable		 5ad6A-4p8bA:
20.81
5ad6B-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5ad8A-4p8bA:
undetectable
5ad8B-4p8bA:
undetectable		 5ad8A-4p8bA:
20.81
5ad8B-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.48A 5ad9A-4p8bA:
undetectable
5ad9B-4p8bA:
undetectable		 5ad9A-4p8bA:
20.81
5ad9B-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.50A 5adaA-4p8bA:
undetectable
5adaB-4p8bA:
undetectable		 5adaA-4p8bA:
20.81
5adaB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADB_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5adbA-4p8bA:
undetectable
5adbB-4p8bA:
undetectable		 5adbA-4p8bA:
20.81
5adbB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 ARG A 106
GLY A 328
THR A 138
GLU A 107
 None
 1.03A 5btaA-4p8bA:
undetectable
5btaB-4p8bA:
undetectable
5btaC-4p8bA:
undetectable		 5btaA-4p8bA:
24.06
5btaB-4p8bA:
23.76
5btaC-4p8bA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 ARG A 106
GLY A 328
THR A 138
GLU A 107
 None
 1.00A 5btcA-4p8bA:
undetectable
5btcC-4p8bA:
undetectable
5btcD-4p8bA:
undetectable		 5btcA-4p8bA:
24.06
5btcC-4p8bA:
24.06
5btcD-4p8bA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 ARG A 106
GLY A 328
THR A 138
GLU A 107
 None
 1.06A 5btcA-4p8bA:
undetectable
5btcB-4p8bA:
undetectable
5btcC-4p8bA:
undetectable		 5btcA-4p8bA:
24.06
5btcB-4p8bA:
23.76
5btcC-4p8bA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		3 / 3 TRP A 101
ILE A  91
SER A  36
 None
 0.92A 5gqbA-4p8bA:
undetectable		 5gqbA-4p8bA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.46A 5unwA-4p8bA:
undetectable
5unwB-4p8bA:
undetectable		 5unwA-4p8bA:
20.81
5unwB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 5unxA-4p8bA:
undetectable
5unxB-4p8bA:
undetectable		 5unxA-4p8bA:
20.81
5unxB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 5uo0A-4p8bA:
1.0
5uo0B-4p8bA:
undetectable		 5uo0A-4p8bA:
20.81
5uo0B-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5vulA-4p8bA:
undetectable
5vulB-4p8bA:
undetectable		 5vulA-4p8bA:
20.81
5vulB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 5vurA-4p8bA:
undetectable
5vurB-4p8bA:
0.0		 5vurA-4p8bA:
20.81
5vurB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 5vusA-4p8bA:
undetectable
5vusB-4p8bA:
undetectable		 5vusA-4p8bA:
20.81
5vusB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.47A 5vusA-4p8bA:
undetectable
5vusB-4p8bA:
undetectable		 5vusA-4p8bA:
20.81
5vusB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5vuuA-4p8bA:
undetectable
5vuuB-4p8bA:
undetectable		 5vuuA-4p8bA:
20.81
5vuuB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.48A 5vuyA-4p8bA:
undetectable
5vuyB-4p8bA:
undetectable		 5vuyA-4p8bA:
20.87
5vuyB-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.44A 5vuyA-4p8bA:
undetectable
5vuyB-4p8bA:
undetectable		 5vuyA-4p8bA:
20.87
5vuyB-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.50A 5vuzA-4p8bA:
undetectable
5vuzB-4p8bA:
undetectable		 5vuzA-4p8bA:
20.87
5vuzB-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5vv0A-4p8bA:
undetectable
5vv0B-4p8bA:
undetectable		 5vv0A-4p8bA:
20.87
5vv0B-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 5vv1A-4p8bA:
undetectable
5vv1B-4p8bA:
undetectable		 5vv1A-4p8bA:
20.87
5vv1B-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5vv1A-4p8bA:
undetectable
5vv1B-4p8bA:
undetectable		 5vv1A-4p8bA:
20.87
5vv1B-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 5vv3A-4p8bA:
undetectable
5vv3B-4p8bA:
undetectable		 5vv3A-4p8bA:
20.87
5vv3B-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.48A 5vv3A-4p8bA:
undetectable
5vv3B-4p8bA:
undetectable		 5vv3A-4p8bA:
20.87
5vv3B-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		5 / 12 VAL A 157
LEU A 175
GLU A 156
LEU A 304
LEU A 170
 None
 1.17A 6f6iA-4p8bA:
undetectable
6f6iB-4p8bA:
undetectable		 6f6iA-4p8bA:
11.59
6f6iB-4p8bA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		5 / 9 GLY A  46
GLY A  96
TRP A  45
GLU A  82
THR A  72
 None
 1.36A 6nknG-4p8bA:
undetectable
6nknN-4p8bA:
0.9
6nknO-4p8bA:
undetectable		 6nknG-4p8bA:
13.76
6nknN-4p8bA:
22.56
6nknO-4p8bA:
20.47