SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		5 / 8 GLY A 171
GLY A  27
LEU A  24
SER A  50
GLY A  29
 None
 0.89A 1d0vA-4p8eA:
undetectable		 1d0vA-4p8eA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		5 / 8 GLY A 171
GLY A  27
LEU A  24
SER A  50
GLY A  29
 None
 0.90A 1jhaA-4p8eA:
undetectable		 1jhaA-4p8eA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		5 / 9 GLY A 171
GLY A  27
LEU A  24
SER A  50
GLY A  29
 None
 0.88A 1jhoA-4p8eA:
undetectable		 1jhoA-4p8eA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		5 / 9 GLY A 171
GLY A  27
LEU A  24
SER A  50
GLY A  29
 None
 0.90A 1jhrA-4p8eA:
undetectable		 1jhrA-4p8eA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		5 / 9 GLY A 171
GLY A  27
LEU A  24
SER A  50
GLY A  29
 None
 0.89A 1jhyA-4p8eA:
undetectable		 1jhyA-4p8eA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		5 / 9 GLY A 171
GLY A  27
LEU A  24
SER A  50
GLY A  29
 None
 0.88A 1l4nA-4p8eA:
undetectable		 1l4nA-4p8eA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		5 / 9 GLY A 171
GLY A  27
LEU A  24
SER A  50
GLY A  29
 None
 0.89A 1l5kA-4p8eA:
undetectable		 1l5kA-4p8eA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		5 / 9 GLY A 171
GLY A  27
LEU A  24
SER A  50
GLY A  29
 None
 0.89A 1l5lA-4p8eA:
undetectable		 1l5lA-4p8eA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		5 / 9 GLY A 171
GLY A  27
LEU A  24
SER A  50
GLY A  29
 None
 0.88A 1l5mA-4p8eA:
undetectable		 1l5mA-4p8eA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		5 / 11 VAL A 138
ILE A 119
LEU A  69
LEU A  81
LEU A  71
 None
 1.24A 2a15A-4p8eA:
undetectable		 2a15A-4p8eA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		5 / 9 GLY A 171
GLY A  27
LEU A  24
SER A  50
GLY A  29
 None
 0.90A 4kqiA-4p8eA:
undetectable		 4kqiA-4p8eA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		4 / 5 LEU A  51
ALA A 123
VAL A 138
ILE A 100
 None
 0.96A 4xe3A-4p8eA:
undetectable		 4xe3A-4p8eA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		3 / 3 ARG A 151
HIS A 154
ARG A  38
 5RP  A 301 (-2.8A)
ZN  A 302 ( 3.2A)
5RP  A 301 (-3.3A)
 1.09A 5iaoC-4p8eA:
undetectable		 5iaoC-4p8eA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		3 / 3 ARG A 151
HIS A 154
ARG A  38
 5RP  A 301 (-2.8A)
ZN  A 302 ( 3.2A)
5RP  A 301 (-3.3A)
 1.14A 5iaoF-4p8eA:
undetectable		 5iaoF-4p8eA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		4 / 7 ARG A 151
GLU A  73
THR A  97
PRO A  83
 5RP  A 301 (-2.8A)
None
None
None
 1.03A 6a4iB-4p8eA:
undetectable		 6a4iB-4p8eA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE
(Vibrio
cholerae) 		3 / 3 VAL A 159
ALA A 143
GLN A 163
 None
 0.70A 6gb9A-4p8eA:
undetectable		 6gb9A-4p8eA:
19.87