SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Bacillus
subtilis) 		4 / 6 VAL A 237
ARG A  52
LEU A  49
PHE A  37
 None
 1.24A 2f8dA-4p8iA:
undetectable		 2f8dA-4p8iA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Bacillus
subtilis) 		4 / 6 LEU A  49
ASN A  16
GLN A   7
ILE A   2
 None
 1.02A 2jn3A-4p8iA:
undetectable		 2jn3A-4p8iA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Bacillus
subtilis) 		3 / 3 GLU A  48
ASP A 168
ASP A 236
 None
 0.74A 3jb2A-4p8iA:
undetectable		 3jb2A-4p8iA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Bacillus
subtilis) 		5 / 12 ILE A 122
ALA A 106
ILE A 129
TYR A 112
THR A  61
 None
 1.27A 4cd2A-4p8iA:
undetectable		 4cd2A-4p8iA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Bacillus
subtilis) 		5 / 12 GLY A 109
PRO A 110
GLY A  66
ASN A 108
ILE A 102
 None
 1.24A 4n48A-4p8iA:
undetectable		 4n48A-4p8iA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Bacillus
subtilis) 		5 / 12 PHE A 141
ILE A 243
THR A 233
SER A 239
LEU A 240
 None
None
PGE  A1003 (-4.0A)
None
None
 1.26A 4qztC-4p8iA:
undetectable		 4qztC-4p8iA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Bacillus
subtilis) 		4 / 5 ALA A 127
HIS A  40
PRO A 155
PHE A  47
 None
 1.41A 4ze2A-4p8iA:
undetectable		 4ze2A-4p8iA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Bacillus
subtilis) 		5 / 10 ASP A 104
ALA A 119
ILE A 122
GLY A  77
PHE A 114
 None
 1.19A 5i6xA-4p8iA:
undetectable		 5i6xA-4p8iA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4p8i PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE
(Bacillus
subtilis) 		5 / 12 ALA A 127
LEU A  62
ILE A 105
ILE A 102
PHE A 137
 None
 1.06A 5uanB-4p8iA:
undetectable		 5uanB-4p8iA:
20.26