SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		5 / 12 GLY A 217
LEU A 215
LEU A 210
ALA A 246
PHE A 223
 None
 1.17A 1gseA-4p8sA:
undetectable		 1gseA-4p8sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 8 ASN A 261
LEU A 242
ALA A 246
LEU A 247
 None
 0.82A 1hwiB-4p8sA:
undetectable		 1hwiB-4p8sA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 8 ASN A 261
LEU A 242
ALA A 246
LEU A 247
 None
 0.81A 1hwiD-4p8sA:
undetectable		 1hwiD-4p8sA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 8 ASN A 261
LEU A 242
ALA A 246
LEU A 247
 None
 0.82A 1hwiC-4p8sA:
undetectable		 1hwiC-4p8sA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		5 / 11 TYR A 161
LEU A 209
ILE A 231
LEU A 181
LEU A 205
 None
 1.09A 1mrqA-4p8sA:
undetectable		 1mrqA-4p8sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 4 VAL A 218
ALA A 222
LEU A 226
PHE A 199
 None
 1.22A 1q97B-4p8sA:
undetectable		 1q97B-4p8sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		5 / 11 LEU A 181
ASN A 213
LEU A 170
VAL A 218
PHE A 199
 None
 1.47A 1tw4A-4p8sA:
undetectable		 1tw4A-4p8sA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 6 LEU A 258
ARG A 207
THR A 230
LEU A 253
 None
 1.04A 2dysN-4p8sA:
undetectable
2dysW-4p8sA:
undetectable		 2dysN-4p8sA:
18.85
2dysW-4p8sA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 7 LEU A 258
ARG A 207
THR A 230
LEU A 253
 None
 1.09A 2eikA-4p8sA:
undetectable
2eikJ-4p8sA:
undetectable		 2eikA-4p8sA:
18.85
2eikJ-4p8sA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 6 LEU A 136
ASN A 189
GLN A 171
ILE A 150
 None
 1.11A 2jn3A-4p8sA:
undetectable		 2jn3A-4p8sA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		5 / 11 LEU A 111
LEU A  87
SER A  74
LEU A  75
LEU A 105
 None
 1.09A 2xn5A-4p8sA:
undetectable		 2xn5A-4p8sA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 7 THR A 126
LEU A 136
LEU A 113
LEU A 111
 None
 0.92A 3bgdB-4p8sA:
undetectable		 3bgdB-4p8sA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 7 LEU A  75
LEU A 113
SER A  91
ASN A  92
 None
 0.96A 3lm8A-4p8sA:
undetectable
3lm8C-4p8sA:
undetectable		 3lm8A-4p8sA:
20.42
3lm8C-4p8sA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 7 LEU A  75
LEU A 113
SER A  91
ASN A  92
 None
 0.94A 3lm8B-4p8sA:
undetectable
3lm8D-4p8sA:
undetectable		 3lm8B-4p8sA:
20.42
3lm8D-4p8sA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 8 LEU A  75
LEU A 113
SER A  91
ASN A  92
 None
 1.04A 3lm8B-4p8sA:
undetectable
3lm8D-4p8sA:
undetectable		 3lm8B-4p8sA:
20.42
3lm8D-4p8sA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		3 / 3 HIS A 219
ARG A 220
GLU A 245
 None
 0.93A 3qf1A-4p8sA:
undetectable		 3qf1A-4p8sA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		5 / 12 ALA A 176
LEU A 174
LEU A 146
LEU A 154
LEU A 111
 None
 1.15A 3r9cA-4p8sA:
undetectable		 3r9cA-4p8sA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 5 THR A  79
THR A 126
LEU A 113
LEU A  89
 None
 1.04A 4lvcB-4p8sA:
undetectable		 4lvcB-4p8sA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		5 / 11 LEU A 232
LEU A 256
GLU A 245
ALA A 248
LEU A 247
 None
 0.95A 4wg0J-4p8sA:
undetectable
4wg0K-4p8sA:
undetectable
4wg0L-4p8sA:
undetectable		 4wg0J-4p8sA:
3.23
4wg0K-4p8sA:
3.23
4wg0L-4p8sA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		5 / 11 TYR A 161
LEU A 209
ILE A 231
LEU A 181
LEU A 205
 None
 1.09A 4yvpA-4p8sA:
undetectable		 4yvpA-4p8sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		5 / 12 TYR A 161
LEU A 209
ILE A 231
LEU A 181
LEU A 205
 None
 1.13A 4yvpB-4p8sA:
undetectable		 4yvpB-4p8sA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 7 LEU A 258
ARG A 207
THR A 230
LEU A 253
 None
 1.00A 5b1bA-4p8sA:
undetectable
5b1bJ-4p8sA:
undetectable		 5b1bA-4p8sA:
18.85
5b1bJ-4p8sA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		5 / 9 LEU A 210
VAL A 218
LEU A 194
PRO A 243
ALA A 246
 None
 1.32A 5og9A-4p8sA:
undetectable		 5og9A-4p8sA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4p8s RETICULON-4
RECEPTOR-LIKE 2
(Rattus
norvegicus) 		4 / 8 LEU A 258
ARG A 207
THR A 230
LEU A 253
 None
 0.95A 5zcqN-4p8sA:
undetectable
5zcqW-4p8sA:
undetectable		 5zcqN-4p8sA:
18.85
5zcqW-4p8sA:
13.12