SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 8 LEU A 263
TYR A 138
GLY A 135
TYR A 267
None
0.96A 1jlfA-4p98A:
undetectable
1jlfB-4p98A:
undetectable
1jlfA-4p98A:
20.49
1jlfB-4p98A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 7 LEU A 263
TYR A 138
GLY A 135
TYR A 267
None
1.00A 1lweA-4p98A:
undetectable
1lweA-4p98A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 12 ALA A 185
LEU A 261
GLY A 181
LEU A 143
GLN A 142
None
MLY  A 260 ( 4.1A)
None
None
BR  A 405 (-3.5A)
1.06A 1qabF-4p98A:
undetectable
1qabF-4p98A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 12 ALA A  79
ILE A  39
VAL A 108
ALA A 109
PHE A 112
None
1.07A 1uduB-4p98A:
undetectable
1uduB-4p98A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 7 VAL A  95
SER A 118
LEU A  60
THR A 266
None
1.05A 2f78A-4p98A:
2.9
2f78A-4p98A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 7 VAL A  95
SER A 118
LEU A  60
THR A 266
None
1.05A 2f78B-4p98A:
undetectable
2f78B-4p98A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 6 ASP A  66
LEU A  60
ASP A  92
HIS A 116
None
None
MLZ  A  35 ( 3.8A)
BR  A 411 (-4.3A)
1.15A 3bj8C-4p98A:
undetectable
3bj8D-4p98A:
undetectable
3bj8C-4p98A:
19.63
3bj8D-4p98A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
3 / 3 ASN A 290
ASP A 314
GLN A 310
None
0.83A 3eeyC-4p98A:
undetectable
3eeyC-4p98A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
3 / 3 ASN A 290
ASP A 314
GLN A 310
None
0.82A 3eeyE-4p98A:
undetectable
3eeyE-4p98A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 9 ALA A 189
VAL A 157
GLY A 148
ILE A 178
ALA A 217
None
1.07A 3ektB-4p98A:
undetectable
3ektB-4p98A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 5 PRO A 166
VAL A 171
THR A 240
GLY A 242
None
1.02A 3elzB-4p98A:
undetectable
3elzB-4p98A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 7 LEU A 229
LEU A 309
LEU A 219
LEU A 288
None
0.96A 3g8iA-4p98A:
undetectable
3g8iA-4p98A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 12 GLN A 273
VAL A 133
LEU A 129
SER A 269
GLY A  96
None
1.18A 3kk6B-4p98A:
undetectable
3kk6B-4p98A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 12 GLY A 228
ASP A 225
ASP A 224
ARG A 227
ALA A 233
None
1.20A 3n3iA-4p98A:
undetectable
3n3iA-4p98A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 9 GLY A  64
ALA A  65
ASP A  66
ILE A 274
LEU A  60
None
0.97A 3ogpA-4p98A:
undetectable
3ogpA-4p98A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 12 GLY A 161
GLY A 211
ALA A 209
ALA A 233
ALA A 235
None
None
None
None
BR  A 419 ( 4.5A)
1.06A 3sudA-4p98A:
undetectable
3sudA-4p98A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
6 / 12 ILE A 178
THR A 240
LEU A 229
GLY A 226
ASP A 147
ILE A 241
None
0.88A 4c9lA-4p98A:
undetectable
4c9lA-4p98A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
6 / 12 ILE A 178
THR A 240
LEU A 229
GLY A 226
ASP A 147
ILE A 241
None
0.93A 4c9lB-4p98A:
undetectable
4c9lB-4p98A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
6 / 12 ILE A 178
THR A 240
LEU A 229
GLY A 226
ASP A 147
ILE A 241
None
0.84A 4c9oA-4p98A:
undetectable
4c9oA-4p98A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
6 / 12 ILE A 178
THR A 240
LEU A 229
GLY A 226
ASP A 147
ILE A 241
None
0.84A 4c9oB-4p98A:
undetectable
4c9oB-4p98A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 6 TRP A 136
ASN A  50
TYR A 138
LEU A 261
None
BR  A 418 (-3.6A)
None
MLY  A 260 ( 4.1A)
1.46A 4f8yA-4p98A:
5.8
4f8yB-4p98A:
5.5
4f8yA-4p98A:
18.24
4f8yB-4p98A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 12 ALA A  51
ILE A 241
LEU A 143
LEU A 146
GLY A 148
BR  A 412 ( 4.0A)
None
None
None
None
1.00A 4l9qB-4p98A:
undetectable
4l9qB-4p98A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
3 / 3 ASP A  46
TRP A 136
SER A  41
None
None
BR  A 418 ( 2.9A)
1.07A 4lrhF-4p98A:
undetectable
4lrhF-4p98A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 11 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
0.98A 4qvlK-4p98A:
undetectable
4qvlL-4p98A:
undetectable
4qvlK-4p98A:
21.86
4qvlL-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 11 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
0.98A 4qvlY-4p98A:
undetectable
4qvlZ-4p98A:
undetectable
4qvlY-4p98A:
21.86
4qvlZ-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 9 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
0.98A 4qvmK-4p98A:
undetectable
4qvmL-4p98A:
undetectable
4qvmK-4p98A:
21.86
4qvmL-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 10 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
0.98A 4qvmY-4p98A:
undetectable
4qvmZ-4p98A:
undetectable
4qvmY-4p98A:
21.86
4qvmZ-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 10 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
0.99A 4qvpK-4p98A:
undetectable
4qvpL-4p98A:
undetectable
4qvpK-4p98A:
21.86
4qvpL-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 10 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
0.99A 4qvpY-4p98A:
undetectable
4qvpZ-4p98A:
undetectable
4qvpY-4p98A:
21.86
4qvpZ-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 11 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
0.99A 4qw1K-4p98A:
undetectable
4qw1L-4p98A:
undetectable
4qw1K-4p98A:
20.91
4qw1L-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 10 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
1.00A 4qw1Y-4p98A:
undetectable
4qw1Z-4p98A:
undetectable
4qw1Y-4p98A:
20.91
4qw1Z-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 10 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
0.98A 4qw3K-4p98A:
undetectable
4qw3L-4p98A:
undetectable
4qw3K-4p98A:
21.86
4qw3L-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 10 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
0.98A 4qw3Y-4p98A:
undetectable
4qw3Z-4p98A:
undetectable
4qw3Y-4p98A:
21.86
4qw3Z-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 10 LEU A 295
LEU A 219
ALA A 162
ALA A 151
GLY A 242
None
1.38A 4rn6A-4p98A:
undetectable
4rn6A-4p98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 7 ALA A  56
ASP A 284
ARG A 282
THR A 278
None
0.99A 5bs8A-4p98A:
undetectable
5bs8B-4p98A:
undetectable
5bs8C-4p98A:
undetectable
5bs8A-4p98A:
22.29
5bs8B-4p98A:
24.09
5bs8C-4p98A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 7 ALA A  56
ASP A 284
ARG A 282
THR A 278
None
0.98A 5btdA-4p98A:
undetectable
5btdB-4p98A:
undetectable
5btdC-4p98A:
undetectable
5btdA-4p98A:
22.29
5btdB-4p98A:
24.09
5btdC-4p98A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 7 ALA A  56
ASP A 284
ARG A 282
THR A 278
None
0.98A 5btdA-4p98A:
undetectable
5btdC-4p98A:
undetectable
5btdD-4p98A:
undetectable
5btdA-4p98A:
22.29
5btdC-4p98A:
22.29
5btdD-4p98A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 11 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
0.98A 5bxnK-4p98A:
undetectable
5bxnL-4p98A:
undetectable
5bxnK-4p98A:
21.86
5bxnL-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 11 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
0.98A 5bxnY-4p98A:
undetectable
5bxnZ-4p98A:
undetectable
5bxnY-4p98A:
21.86
5bxnZ-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 9 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
0.99A 5d0xK-4p98A:
undetectable
5d0xL-4p98A:
undetectable
5d0xK-4p98A:
20.65
5d0xL-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 9 THR A 174
ALA A 173
GLY A 148
GLY A 181
ALA A 180
None
BR  A 406 ( 4.7A)
None
None
BR  A 421 (-4.1A)
0.99A 5d0xY-4p98A:
undetectable
5d0xZ-4p98A:
undetectable
5d0xY-4p98A:
20.65
5d0xZ-4p98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 9 ILE A  38
THR A 266
TRP A 136
ASN A  50
LEU A 286
None
None
None
BR  A 418 (-3.6A)
None
1.06A 5fhzB-4p98A:
3.8
5fhzB-4p98A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 9 THR A 266
TRP A 136
GLN A  43
ASN A  50
LEU A 286
None
None
None
BR  A 418 (-3.6A)
None
1.16A 5fhzB-4p98A:
3.8
5fhzB-4p98A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 10 ILE A  38
THR A 266
TRP A 136
ASN A  50
LEU A 286
None
None
None
BR  A 418 (-3.6A)
None
1.09A 5fhzC-4p98A:
3.0
5fhzC-4p98A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
5 / 10 THR A 266
TRP A 136
GLN A  43
ASN A  50
LEU A 286
None
None
None
BR  A 418 (-3.6A)
None
1.33A 5fhzC-4p98A:
3.0
5fhzC-4p98A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 4 GLU A 103
PRO A 104
ILE A 105
LEU A 106
None
1.23A 5m45A-4p98A:
undetectable
5m45A-4p98A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 4 GLU A 103
PRO A 104
ILE A 105
LEU A 106
None
1.27A 5m45D-4p98A:
undetectable
5m45D-4p98A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 4 GLU A 103
PRO A 104
ILE A 105
LEU A 106
None
1.26A 5m45G-4p98A:
undetectable
5m45G-4p98A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
4 / 4 GLU A 103
PRO A 104
ILE A 105
LEU A 106
None
1.29A 5m45J-4p98A:
undetectable
5m45J-4p98A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei)
3 / 3 SER A 120
SER A 118
PHE A  49
BR  A 402 (-3.3A)
None
None
0.72A 5mugA-4p98A:
undetectable
5mugA-4p98A:
20.38