SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4p9a POLYMERASE PA
(Influenza
A
virus) 		3 / 3 GLN A 365
LYS A 339
VAL A 341
 None
 0.65A 2jfaB-4p9aA:
undetectable		 2jfaB-4p9aA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 4p9a POLYMERASE PA
(Influenza
A
virus) 		4 / 5 LEU A 345
LEU A 342
LEU A 543
MET A 311
 None
 0.94A 2oaxF-4p9aA:
undetectable		 2oaxF-4p9aA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 4p9a POLYMERASE PA
(Influenza
A
virus) 		4 / 6 ILE A 483
ILE A 545
TRP A 338
MET A 523
 None
 1.49A 3welA-4p9aA:
undetectable		 3welA-4p9aA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4p9a POLYMERASE PA
(Influenza
A
virus) 		4 / 6 TRP A 317
ILE A 545
ILE A 505
VAL A 521
 None
 0.95A 4zj8A-4p9aA:
undetectable		 4zj8A-4p9aA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4p9a POLYMERASE PA
(Influenza
A
virus) 		5 / 12 SER A 291
THR A 498
ILE A 292
LEU A 283
LEU A 563
 None
 1.31A 6a93A-4p9aA:
undetectable		 6a93A-4p9aA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4p9a POLYMERASE PA
(Influenza
A
virus) 		5 / 12 SER A 291
THR A 498
ILE A 292
PHE A 525
LEU A 563
 None
 1.42A 6a93A-4p9aA:
undetectable		 6a93A-4p9aA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 4p9a POLYMERASE PA
(Influenza
A
virus) 		3 / 3 TYR A 650
ALA A 414
LEU A 284
 None
 0.74A 6d9kF-4p9aA:
undetectable		 6d9kF-4p9aA:
22.41