SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p9f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR
(Escherichia
coli) 		4 / 8 HIS A 144
TYR A 143
LEU A 140
GLU A 153
 None
 0.97A 1i7zA-4p9fA:
undetectable		 1i7zA-4p9fA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR
(Escherichia
coli) 		5 / 12 GLU A  93
LEU A  82
ILE A  85
ILE A 155
LEU A 158
 None
 1.21A 1kyvA-4p9fA:
undetectable
1kyvE-4p9fA:
undetectable		 1kyvA-4p9fA:
22.90
1kyvE-4p9fA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR
(Escherichia
coli) 		5 / 12 ILE A 155
LEU A 158
GLU A  93
LEU A  82
ILE A  85
 None
 1.21A 1kyvB-4p9fA:
undetectable
1kyvC-4p9fA:
undetectable		 1kyvB-4p9fA:
22.90
1kyvC-4p9fA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR
(Escherichia
coli) 		5 / 12 ILE A 155
LEU A 158
GLU A  93
LEU A  82
ILE A  85
 None
 1.21A 1kyvC-4p9fA:
undetectable
1kyvD-4p9fA:
undetectable		 1kyvC-4p9fA:
22.90
1kyvD-4p9fA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR
(Escherichia
coli) 		5 / 12 ILE A 155
LEU A 158
GLU A  93
LEU A  82
ILE A  85
 None
 1.20A 1kyvD-4p9fA:
undetectable
1kyvE-4p9fA:
undetectable		 1kyvD-4p9fA:
22.90
1kyvE-4p9fA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR
(Escherichia
coli) 		4 / 4 LEU A 215
PRO A  75
ILE A  85
LEU A  82
 None
 0.83A 1ya4B-4p9fA:
undetectable		 1ya4B-4p9fA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR
(Escherichia
coli) 		4 / 4 LEU A 215
PRO A  75
ILE A  85
LEU A  82
 None
 0.88A 1ya4C-4p9fA:
undetectable		 1ya4C-4p9fA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR
(Escherichia
coli) 		4 / 6 LEU A 151
MET A  95
LEU A  99
MET A 148
 None
 1.24A 2kuhA-4p9fA:
undetectable		 2kuhA-4p9fA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR
(Escherichia
coli) 		4 / 6 LEU A 112
LEU A 109
ILE A 142
ARG A 145
 None
 0.98A 2rlfC-4p9fA:
undetectable
2rlfD-4p9fA:
undetectable		 2rlfC-4p9fA:
14.44
2rlfD-4p9fA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR
(Escherichia
coli) 		3 / 3 ASN A 133
ASP A  19
GLN A  15
 None
 0.79A 3eeyC-4p9fA:
undetectable		 3eeyC-4p9fA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR
(Escherichia
coli) 		3 / 3 ASN A 133
ASP A  19
GLN A  15
 None
 0.80A 3eeyD-4p9fA:
undetectable		 3eeyD-4p9fA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR
(Escherichia
coli) 		3 / 3 ASN A 133
ASP A  19
GLN A  15
 None
 0.79A 3eeyE-4p9fA:
undetectable		 3eeyE-4p9fA:
21.12