SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p9k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		5 / 12 ILE A 195
ALA A 189
THR A 239
PRO A 220
ASN A 219
 None
None
None
None
EAX  A 401 (-2.8A)
 1.00A 1dhfA-4p9kA:
undetectable		 1dhfA-4p9kA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		4 / 8 GLU A 154
VAL A 281
ARG A 121
ASP A 282
 None
 1.04A 1s3zA-4p9kA:
undetectable
1s3zB-4p9kA:
undetectable		 1s3zA-4p9kA:
20.30
1s3zB-4p9kA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		4 / 8 GLU A 154
VAL A 281
HIS A 125
ASP A 282
 None
 1.14A 1s3zA-4p9kA:
undetectable
1s3zB-4p9kA:
undetectable		 1s3zA-4p9kA:
20.30
1s3zB-4p9kA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		5 / 12 ASP A 284
VAL A 281
HIS A  49
ALA A 126
PHE A 120
 None
 1.34A 2g70A-4p9kA:
undetectable		 2g70A-4p9kA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		5 / 12 ASP A 284
VAL A 281
HIS A  49
ALA A 126
PHE A 120
 None
 1.35A 2g72A-4p9kA:
undetectable		 2g72A-4p9kA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		3 / 3 VAL A 281
ASP A 282
GLU A 154
 None
 0.66A 2qeuA-4p9kA:
undetectable		 2qeuA-4p9kA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		3 / 3 VAL A 281
ASP A 282
GLU A 154
 None
 0.68A 2qeuC-4p9kA:
undetectable		 2qeuC-4p9kA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		4 / 9 PHE A  57
ALA A  58
VAL A  61
GLU A  62
 None
 0.47A 2vufA-4p9kA:
undetectable		 2vufA-4p9kA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		3 / 3 ASN A 219
ASP A 230
GLN A 231
 EAX  A 401 (-2.8A)
None
None
 0.79A 3eeyC-4p9kA:
undetectable		 3eeyC-4p9kA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		3 / 3 ASN A 219
ASP A 230
GLN A 231
 EAX  A 401 (-2.8A)
None
None
 0.79A 3eeyD-4p9kA:
undetectable		 3eeyD-4p9kA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		3 / 3 ASN A 219
ASP A 230
GLN A 231
 EAX  A 401 (-2.8A)
None
None
 0.79A 3eeyE-4p9kA:
undetectable		 3eeyE-4p9kA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		5 / 11 LEU A 221
GLY A 156
ILE A 225
SER A  48
VAL A 281
 None
 1.12A 3gyqB-4p9kA:
undetectable		 3gyqB-4p9kA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		5 / 11 PRO A 105
ALA A 327
PHE A 323
PHE A 319
ILE A 331
 None
 1.34A 3n23A-4p9kA:
undetectable		 3n23A-4p9kA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		5 / 11 PRO A 105
LEU A 138
ALA A 327
PHE A 323
PHE A 319
 None
 1.25A 3n23C-4p9kA:
undetectable		 3n23C-4p9kA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		4 / 5 GLU A  62
GLY A  66
TYR A  69
ASP A 262
 None
 1.40A 3w9tD-4p9kA:
undetectable		 3w9tD-4p9kA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		5 / 12 TYR A 190
HIS A 186
GLN A 318
VAL A 315
PHE A 193
 None
 1.12A 4drhD-4p9kA:
undetectable		 4drhD-4p9kA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		4 / 7 MET A 181
HIS A  49
GLY A 156
ASN A 155
 EAX  A 401 (-3.3A)
None
None
EAX  A 401 (-3.4A)
 1.37A 5a5zC-4p9kA:
undetectable		 5a5zC-4p9kA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4p9k TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Verminephrobacte
r
eiseniae) 		5 / 12 ARG A 278
GLN A 264
LEU A 139
GLY A 273
ALA A 274
 None
 0.94A 5jw1B-4p9kA:
undetectable		 5jw1B-4p9kA:
18.35