SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p9n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 7 GLY A 286
ILE A 239
TYR A 177
GLY A 275
 None
 0.86A 11gsB-4p9nA:
undetectable		 11gsB-4p9nA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACL_A_DMEA999_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 10 SER A 151
TRP A 205
PHE A 197
HIS A 274
GLY A 275
 None
 1.39A 1aclA-4p9nA:
18.4		 1aclA-4p9nA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 8 GLY A  80
SER A 151
PHE A 197
HIS A 274
 None
 0.85A 1ax9A-4p9nA:
18.1		 1ax9A-4p9nA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		6 / 12 GLY A  79
GLY A  80
GLY A  81
SER A 151
PHE A 197
HIS A 274
 None
 0.41A 1dx6A-4p9nA:
18.5		 1dx6A-4p9nA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 GLY A  79
GLY A  81
SER A 151
PHE A 206
HIS A 274
 None
 1.01A 1dx6A-4p9nA:
18.5		 1dx6A-4p9nA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 6 PHE A 118
TYR A 210
LEU A 156
VAL A 159
 None
 1.15A 1dz4A-4p9nA:
undetectable		 1dz4A-4p9nA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 6 PHE A 269
ILE A 283
LYS A 287
ALA A 289
 None
 1.25A 1hk2A-4p9nA:
undetectable		 1hk2A-4p9nA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 8 ILE A 174
LEU A  74
PHE A 301
GLY A 144
 None
 1.08A 1os6A-4p9nA:
undetectable		 1os6A-4p9nA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		6 / 12 PHE A  82
GLY A 149
GLY A 153
LEU A 156
ILE A 174
ILE A 238
 None
 1.41A 1qaoA-4p9nA:
2.5		 1qaoA-4p9nA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		6 / 12 GLY A  79
GLY A  80
GLY A  81
SER A 151
PHE A 206
HIS A 274
 None
 0.96A 1qtiA-4p9nA:
18.1		 1qtiA-4p9nA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A 175
ILE A 147
LEU A  77
GLY A 153
GLY A 154
 None
 0.82A 1uakA-4p9nA:
undetectable		 1uakA-4p9nA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		6 / 12 GLY A  79
GLY A  80
GLY A  81
SER A 151
PHE A 197
HIS A 274
 None
 0.61A 1w6rA-4p9nA:
18.5		 1w6rA-4p9nA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		6 / 12 GLY A  79
GLY A  81
SER A 151
PHE A 206
PHE A 197
HIS A 274
 None
 1.00A 1w6rA-4p9nA:
18.5		 1w6rA-4p9nA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 11 GLY A  80
GLY A  81
SER A 151
PHE A 197
HIS A 274
 None
 0.40A 1w76A-4p9nA:
17.5		 1w76A-4p9nA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 11 GLY A  80
GLY A  81
SER A 151
PHE A 206
HIS A 274
 None
 0.96A 1w76A-4p9nA:
17.5		 1w76A-4p9nA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A  79
GLY A  80
SER A 151
PHE A 206
HIS A 274
 None
 0.91A 1w76B-4p9nA:
17.5		 1w76B-4p9nA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 9 GLY A  79
GLY A  80
SER A 151
ALA A 152
HIS A 274
 None
 0.93A 2aceA-4p9nA:
4.7		 2aceA-4p9nA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		7 / 9 GLY A  80
GLY A  81
SER A 151
ALA A 152
PHE A 206
PHE A 197
HIS A 274
 None
 0.85A 2aceA-4p9nA:
4.7		 2aceA-4p9nA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 8 GLY A  80
GLY A  81
ALA A 152
PHE A 206
HIS A 274
 None
 0.98A 2ha4A-4p9nA:
18.1		 2ha4A-4p9nA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 7 GLY A  80
GLY A  81
ALA A 152
PHE A 206
HIS A 274
 None
 0.99A 2ha4B-4p9nA:
18.5		 2ha4B-4p9nA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 5 PHE A 118
TYR A 210
LEU A 156
VAL A 159
 None
 1.16A 2m56A-4p9nA:
undetectable		 2m56A-4p9nA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 8 ILE A  49
LEU A 136
PHE A 139
PHE A  64
 None
 0.87A 2vctA-4p9nA:
undetectable		 2vctA-4p9nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 8 ILE A  49
LEU A 136
PHE A 139
PHE A  64
 None
 0.86A 2vctB-4p9nA:
undetectable		 2vctB-4p9nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 7 ILE A  49
LEU A 136
PHE A 139
PHE A  64
 None
 0.77A 2vctD-4p9nA:
undetectable		 2vctD-4p9nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 9 ARG A 221
LEU A 163
ILE A  51
GLY A  53
VAL A 122
 None
 1.04A 3d1yB-4p9nA:
undetectable		 3d1yB-4p9nA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 4 GLY A  72
TYR A  71
GLY A  69
ASP A 140
 None
 1.35A 3kl3A-4p9nA:
undetectable		 3kl3A-4p9nA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 7 TYR A 133
VAL A  75
ILE A  51
ARG A 221
 None
 1.09A 3mssB-4p9nA:
undetectable		 3mssB-4p9nA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 7 GLY A  80
GLY A  81
SER A 151
HIS A 274
 None
 0.37A 3o9mA-4p9nA:
18.5		 3o9mA-4p9nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 6 GLY A  80
GLY A  81
SER A 151
HIS A 274
 None
 0.43A 3o9mB-4p9nA:
18.6		 3o9mB-4p9nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A 156
HIS A 274
TYR A  90
SER A 278
LEU A  77
 None
 1.20A 3okxA-4p9nA:
undetectable		 3okxA-4p9nA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 5 SER A 120
ARG A  28
ASP A 109
THR A  56
 None
 1.39A 3okxA-4p9nA:
undetectable		 3okxA-4p9nA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 5 SER A 120
ARG A  28
ASP A 109
THR A  56
 None
 1.42A 3okxB-4p9nA:
undetectable		 3okxB-4p9nA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 8 GLY A 153
TYR A  90
ASP A  86
SER A  89
 None
 0.85A 3pwwA-4p9nA:
undetectable		 3pwwA-4p9nA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		3 / 3 TYR A  63
ASP A  86
ASP A  91
 None
 0.63A 3r24A-4p9nA:
undetectable		 3r24A-4p9nA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 9 ILE A 174
LEU A  74
PHE A 301
MET A 143
GLY A 144
 None
 1.24A 3sj4X-4p9nA:
undetectable		 3sj4X-4p9nA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A 198
ILE A  84
ILE A 203
ILE A  19
ALA A 152
 None
 0.98A 3uj7A-4p9nA:
3.5		 3uj7A-4p9nA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A 198
ILE A  84
ILE A 203
ILE A  19
ALA A 152
 None
 1.00A 3uj7B-4p9nA:
4.0		 3uj7B-4p9nA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A 297
LEU A 136
GLY A 141
PHE A 139
ILE A 145
 None
 1.08A 3uwlD-4p9nA:
undetectable		 3uwlD-4p9nA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 HIS A 274
GLY A  81
GLY A  79
TYR A 177
ALA A 113
 None
 1.13A 3vywB-4p9nA:
2.2		 3vywB-4p9nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 HIS A 274
GLY A  81
GLY A  79
TYR A 177
ALA A 113
 None
 1.11A 3vywD-4p9nA:
undetectable		 3vywD-4p9nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 6 PHE A 118
TYR A 210
LEU A 156
VAL A 159
 None
 1.06A 4ek1A-4p9nA:
undetectable		 4ek1A-4p9nA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		6 / 12 GLY A  79
GLY A  80
GLY A  81
SER A 151
PHE A 206
HIS A 274
 None
 0.95A 4ey6A-4p9nA:
8.1		 4ey6A-4p9nA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		6 / 12 GLY A  79
GLY A  80
GLY A  81
SER A 151
PHE A 206
HIS A 274
 None
 0.94A 4ey6B-4p9nA:
18.1		 4ey6B-4p9nA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 11 GLY A  80
SER A 151
TRP A 205
HIS A 274
GLY A 275
 None
 1.39A 4ey7A-4p9nA:
18.6		 4ey7A-4p9nA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 11 GLY A  80
SER A 151
TRP A 205
HIS A 274
GLY A 275
 None
 1.41A 4ey7B-4p9nA:
18.4		 4ey7B-4p9nA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 ALA A 179
SER A 151
GLY A 207
LEU A 198
PRO A 245
 None
 1.11A 4uilH-4p9nA:
undetectable
4uilL-4p9nA:
undetectable		 4uilH-4p9nA:
22.08
4uilL-4p9nA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 8 PRO A 281
PHE A  15
PHE A 280
TYR A 177
 None
 1.44A 4v2zC-4p9nA:
undetectable		 4v2zC-4p9nA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A 297
LEU A  77
PRO A 178
ILE A 238
VAL A 104
 None
 1.50A 5dlvB-4p9nA:
1.8		 5dlvB-4p9nA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		3 / 3 ILE A  51
PRO A  52
ILE A  58
 None
 0.43A 5hw8F-4p9nA:
undetectable		 5hw8F-4p9nA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A 297
LEU A 136
GLY A 141
PHE A 139
ILE A 145
 None
 1.09A 5j7wC-4p9nA:
undetectable		 5j7wC-4p9nA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A 175
GLY A 153
ASN A 155
ALA A 161
TYR A  76
 None
 1.08A 5kbwB-4p9nA:
1.4		 5kbwB-4p9nA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 9 ARG A 221
LEU A 163
ILE A  51
GLY A  53
VAL A 122
 None
 0.98A 5kr2D-4p9nA:
undetectable		 5kr2D-4p9nA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		3 / 3 MET A 189
GLU A 201
ARG A 200
 None
 1.06A 5tjzA-4p9nA:
4.3		 5tjzA-4p9nA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		4 / 7 PHE A 118
TYR A 210
LEU A 156
VAL A 159
 None
 1.03A 5wk9A-4p9nA:
undetectable		 5wk9A-4p9nA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A 175
ILE A 147
LEU A  77
GLY A 153
GLY A 154
 None
 0.85A 5wyqB-4p9nA:
2.3		 5wyqB-4p9nA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A 175
ILE A 147
LEU A  77
GLY A 153
GLY A 154
 None
 0.79A 5zhmB-4p9nA:
2.5		 5zhmB-4p9nA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		3 / 3 TYR A 172
PRO A 234
LEU A 170
 None
 0.89A 6beoA-4p9nA:
undetectable		 6beoA-4p9nA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 VAL A  17
PHE A 197
TRP A 205
PHE A 206
VAL A  83
 None
 1.40A 6drxA-4p9nA:
undetectable		 6drxA-4p9nA:
21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IEY_A_CLMA401_0
(ESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		7 / 11 ILE A  84
ASP A 150
LEU A 198
HIS A 274
GLY A 275
PHE A  31
ALA A  35
 None
 0.59A 6ieyA-4p9nA:
40.4
6ieyB-4p9nA:
40.4		 6ieyA-4p9nA:
37.50
6ieyB-4p9nA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IEY_A_CLMA401_0
(ESTERASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		7 / 11 ILE A  84
ASP A 150
LEU A 198
HIS A 274
GLY A 275
SER A 278
PHE A  31
 None
 0.69A 6ieyA-4p9nA:
40.4
6ieyB-4p9nA:
40.4		 6ieyA-4p9nA:
37.50
6ieyB-4p9nA:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A 297
LEU A 136
GLY A 141
PHE A 139
ILE A 145
 None
 1.08A 6qyaB-4p9nA:
undetectable		 6qyaB-4p9nA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4p9n CARBOXYLESTERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A 297
LEU A 136
GLY A 141
PHE A 139
ILE A 145
 None
 1.09A 6qyaD-4p9nA:
undetectable		 6qyaD-4p9nA:
23.24