SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4p9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		4 / 8 TYR E 255
LEU E 192
ASP E 185
LEU E 188
 None
 1.04A 1e7cA-4p9uE:
2.1		 1e7cA-4p9uE:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		3 / 3 GLU E 155
TYR E 153
PHE E 183
 None
 0.88A 1eqbB-4p9uE:
undetectable		 1eqbB-4p9uE:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		3 / 3 GLU E 155
TYR E 153
PHE E 183
 None
 0.87A 1eqbA-4p9uE:
undetectable		 1eqbA-4p9uE:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		3 / 3 GLU E 155
TYR E 153
PHE E 183
 None
 0.88A 1eqbD-4p9uE:
undetectable		 1eqbD-4p9uE:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		3 / 3 GLU E 155
TYR E 153
PHE E 183
 None
 0.88A 1eqbC-4p9uE:
undetectable		 1eqbC-4p9uE:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		4 / 6 VAL E 131
ARG E 191
LEU E 192
HIS E 195
 None
 1.15A 2f8dA-4p9uE:
undetectable		 2f8dA-4p9uE:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		5 / 10 PHE E  25
SER E  19
LEU E  48
VAL E  43
VAL E  51
 None
 1.38A 3u9fI-4p9uE:
undetectable		 3u9fI-4p9uE:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		4 / 5 LEU E 138
ARG E 226
PRO E 223
ALA E 225
 None
 1.43A 3vm4A-4p9uE:
undetectable		 3vm4A-4p9uE:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		3 / 3 ARG E 105
ASP E 185
TYR E 219
 None
 0.79A 4yo9B-4p9uE:
undetectable		 4yo9B-4p9uE:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		4 / 6 ASP E 185
TYR E 219
PHE E 232
TYR E 233
 None
 1.42A 5e2iA-4p9uE:
undetectable		 5e2iA-4p9uE:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		4 / 6 ARG E 191
LEU E 188
ALA E 229
GLN E 190
 None
 1.08A 6b89B-4p9uE:
undetectable		 6b89B-4p9uE:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		3 / 3 ARG E 191
HIS E 195
ARG E 126
 None
 1.09A 6dwdD-4p9uE:
undetectable		 6dwdD-4p9uE:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		3 / 3 HIS E 195
ASN E 120
LEU E 119
 None
 0.83A 6f7lB-4p9uE:
undetectable		 6f7lB-4p9uE:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4p9u FATTY ACID
METABOLISM REGULATOR
PROTEIN
(Vibrio
cholerae) 		5 / 12 PHE E  74
ILE E  20
LEU E  40
LEU E  55
ALA E  12
 None
 1.15A 6r2eH-4p9uE:
undetectable		 6r2eH-4p9uE:
20.60