SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pa1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4pa1 INTEGRASE
(Feline
immunodeficiency
virus) 		3 / 3 GLN A  89
LYS A 101
VAL A 103
 None
 0.86A 2jfaB-4pa1A:
undetectable		 2jfaB-4pa1A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4pa1 INTEGRASE
(Feline
immunodeficiency
virus) 		4 / 6 PHE A 141
GLN A  64
ASN A 111
LEU A 202
 None
 1.10A 2nyrA-4pa1A:
undetectable		 2nyrA-4pa1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 4pa1 INTEGRASE
(Feline
immunodeficiency
virus) 		4 / 8 ILE A 164
ILE A  90
MET A  65
GLY A  78
 None
 0.93A 4hdlA-4pa1A:
undetectable		 4hdlA-4pa1A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4pa1 INTEGRASE
(Feline
immunodeficiency
virus) 		4 / 6 VAL A 103
LEU A 104
LEU A 132
MET A  60
 None
 0.97A 4o1zA-4pa1A:
undetectable		 4o1zA-4pa1A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4pa1 INTEGRASE
(Feline
immunodeficiency
virus) 		4 / 8 ASP A  66
ASP A 118
GLU A  94
ILE A  74
 None
 1.05A 5cfsA-4pa1A:
undetectable		 5cfsA-4pa1A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 4pa1 INTEGRASE
(Feline
immunodeficiency
virus) 		3 / 3 HIS A 183
ASN A 186
ALA A 197
 None
 0.61A 5n4tB-4pa1A:
1.6		 5n4tB-4pa1A:
20.51