SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4paf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		5 / 10 GLY A 239
PHE A 144
VAL A 142
GLY A 141
VAL A 265
 None
 1.26A 1pwyE-4pafA:
undetectable		 1pwyE-4pafA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		5 / 10 GLY A 239
PHE A 144
VAL A 142
GLY A 141
VAL A 265
 None
 1.27A 1v3qE-4pafA:
undetectable		 1v3qE-4pafA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		4 / 6 LEU A 169
ASN A 182
ILE A 171
PHE A 180
 None
 0.87A 1xf1B-4pafA:
undetectable		 1xf1B-4pafA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		4 / 7 ARG A 127
GLU A 318
ASN A 101
ALA A 104
 None
 1.13A 2ejgA-4pafA:
undetectable		 2ejgA-4pafA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		5 / 12 ASP A 209
ILE A 171
ILE A 177
ALA A 161
HIS A 232
 None
 1.40A 2qmjA-4pafA:
undetectable		 2qmjA-4pafA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		5 / 12 ALA A  44
MET A 261
ALA A 262
VAL A 142
LEU A  85
 None
 1.18A 3b0wA-4pafA:
undetectable		 3b0wA-4pafA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		5 / 12 ALA A  44
MET A 261
ALA A 262
VAL A 142
LEU A  85
 None
 1.17A 3b0wB-4pafA:
undetectable		 3b0wB-4pafA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		5 / 12 MET A 261
ALA A 262
VAL A 142
LEU A  77
LEU A  85
 None
 1.31A 3b0wB-4pafA:
undetectable		 3b0wB-4pafA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		5 / 9 GLY A 138
ALA A 137
VAL A  95
GLY A 141
ILE A 241
 None
 0.99A 3ektA-4pafA:
undetectable		 3ektA-4pafA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		5 / 10 MET A 102
ALA A 323
ILE A 120
LEU A 121
PHE A 105
 None
 1.24A 3fl9A-4pafA:
undetectable		 3fl9A-4pafA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		5 / 10 MET A 102
ALA A 323
ILE A 120
LEU A 121
PHE A 105
 None
 1.15A 3fl9F-4pafA:
undetectable		 3fl9F-4pafA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		5 / 10 GLY A 138
ALA A 137
VAL A  95
GLY A 141
ILE A 241
 None
 0.99A 3oy4B-4pafA:
undetectable		 3oy4B-4pafA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		3 / 3 ARG A 150
PHE A 235
PRO A 236
 DHB  A 401 (-2.8A)
DHB  A 401 (-4.5A)
None
 0.87A 3zoaB-4pafA:
undetectable		 3zoaB-4pafA:
19.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		12 / 12 ILE A  34
THR A  35
HIS A  39
TRP A  41
THR A  91
ALA A 147
ARG A 150
ARG A 170
LEU A 193
ASP A 211
LEU A 214
PHE A 235
 DHB  A 401 ( 4.8A)
DHB  A 401 (-4.2A)
DHB  A 401 (-3.8A)
DHB  A 401 (-2.9A)
DHB  A 401 (-4.2A)
DHB  A 401 (-2.8A)
DHB  A 401 (-2.8A)
DHB  A 401 (-3.0A)
DHB  A 401 (-4.8A)
DHB  A 401 (-2.9A)
DHB  A 401 (-4.5A)
DHB  A 401 (-4.5A)
 0.10A 4pbhA-4pafA:
55.6		 4pbhA-4pafA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		3 / 3 LEU A 121
ARG A 122
ARG A 127
 None
 0.95A 4yiaB-4pafA:
undetectable		 4yiaB-4pafA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		4 / 6 VAL A 293
LEU A 164
ILE A 152
THR A 226
 None
 0.67A 4zf8A-4pafA:
undetectable		 4zf8A-4pafA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		4 / 7 LYS A  27
GLY A  58
SER A  53
LEU A  52
 None
 1.14A 5bphB-4pafA:
undetectable		 5bphB-4pafA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		3 / 3 HIS A  60
LYS A  27
PHE A  29
 None
 1.49A 5klaA-4pafA:
undetectable		 5klaA-4pafA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		3 / 3 TYR A 109
HIS A 232
MET A 149
 None
 1.11A 6af6A-4pafA:
undetectable		 6af6A-4pafA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		5 / 12 PHE A 235
LEU A 110
SER A  96
ILE A 177
ASP A 209
 DHB  A 401 (-4.5A)
None
None
None
None
 1.49A 6bxnA-4pafA:
undetectable		 6bxnA-4pafA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE
(Ruegeria
pomeroyi) 		5 / 10 ARG A  98
VAL A  95
GLY A 138
GLY A 143
VAL A 238
 None
 1.19A 6eu9B-4pafA:
undetectable		 6eu9B-4pafA:
13.91