SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pag'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		4 / 7 TYR A 149
THR A 111
VAL A 108
ILE A 110
 None
 0.98A 1p7rA-4pagA:
undetectable		 1p7rA-4pagA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		5 / 11 GLY A  41
SER A  42
ALA A 132
LEU A 125
VAL A 135
 None
 0.85A 1ukbA-4pagA:
2.6		 1ukbA-4pagA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		4 / 7 PHE A 320
PHE A 338
MET A 292
SER A 290
 None
 1.08A 1wrlE-4pagA:
undetectable		 1wrlE-4pagA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		3 / 3 PHE A 338
ARG A 293
ASN A 283
 None
 0.71A 1xzxX-4pagA:
undetectable		 1xzxX-4pagA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		4 / 7 ASP A  69
PRO A 288
SER A  63
LEU A 117
 None
 1.05A 2hdnE-4pagA:
undetectable
2hdnF-4pagA:
2.4
2hdnH-4pagA:
2.4		 2hdnE-4pagA:
8.68
2hdnF-4pagA:
22.55
2hdnH-4pagA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		4 / 7 SER A  63
LEU A 117
ASP A  69
PRO A 288
 None
 1.04A 2hdnF-4pagA:
2.4
2hdnG-4pagA:
undetectable
2hdnH-4pagA:
2.4		 2hdnF-4pagA:
22.55
2hdnG-4pagA:
8.68
2hdnH-4pagA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		4 / 5 PHE A 324
PHE A 325
LEU A  77
PHE A  81
 None
 1.29A 3abmP-4pagA:
undetectable
3abmW-4pagA:
undetectable		 3abmP-4pagA:
18.88
3abmW-4pagA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		5 / 12 MET A 292
PHE A  48
PHE A 324
PHE A 325
ARG A 159
 None
 1.33A 3aodC-4pagA:
undetectable		 3aodC-4pagA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		4 / 5 VAL A 274
GLU A 236
LYS A 262
PHE A 258
 None
 1.06A 3rv5C-4pagA:
0.0
3rv5D-4pagA:
undetectable		 3rv5C-4pagA:
13.06
3rv5D-4pagA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		5 / 11 ILE A 300
ALA A 192
GLU A 201
THR A 200
VAL A 189
 None
 1.02A 3tmzA-4pagA:
undetectable		 3tmzA-4pagA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		3 / 3 TYR A 143
ARG A 293
SER A 140
 None
 1.10A 4khpI-4pagA:
undetectable
4khpJ-4pagA:
undetectable		 4khpI-4pagA:
16.41
4khpJ-4pagA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		5 / 11 ASP A 286
ALA A 192
TYR A 191
GLY A 229
GLY A 194
 None
 1.12A 4mm9A-4pagA:
undetectable		 4mm9A-4pagA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		5 / 9 ASP A 286
ALA A 192
TYR A 191
GLY A 229
GLY A 194
 None
 1.33A 4mmeA-4pagA:
undetectable		 4mmeA-4pagA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		5 / 9 ASP A 286
ALA A 192
TYR A 191
GLY A 229
GLY A 194
 None
 1.31A 4mmeB-4pagA:
undetectable		 4mmeB-4pagA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		5 / 9 ASP A 286
ALA A 192
TYR A 191
GLY A 229
GLY A 194
 None
 1.34A 4mmfA-4pagA:
undetectable		 4mmfA-4pagA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		5 / 9 ASP A 286
ALA A 192
TYR A 191
GLY A 229
GLY A 194
 None
 1.33A 4mmfB-4pagA:
1.3		 4mmfB-4pagA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		5 / 12 ILE A 109
PRO A 131
LEU A 133
LEU A  32
VAL A 153
 None
 1.24A 5im2A-4pagA:
undetectable		 5im2A-4pagA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		4 / 5 TYR A 337
GLU A  74
GLY A  73
SER A 280
 None
 1.37A 5jhdJ-4pagA:
undetectable		 5jhdJ-4pagA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		5 / 12 ILE A 101
PHE A  81
SER A  78
ILE A  53
LEU A  58
 None
 1.18A 5oy02-4pagA:
undetectable		 5oy02-4pagA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		3 / 3 ASP A 195
ASN A 250
ASP A  69
 None
 0.73A 5vopA-4pagA:
2.4		 5vopA-4pagA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		3 / 3 ASP A 195
ASN A 250
ASP A  69
 None
 0.75A 5vopB-4pagA:
undetectable		 5vopB-4pagA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		4 / 5 LEU A 340
LEU A 295
PRO A 288
ARG A 287
 None
 0.91A 6ew0F-4pagA:
undetectable		 6ew0F-4pagA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4pag PERIPLASMIC BINDING
PROTEIN
(Sulfurospirillum
deleyianum) 		4 / 6 LEU A 340
LEU A 295
PRO A 288
ARG A 287
 None
 0.90A 6ew0G-4pagA:
undetectable		 6ew0G-4pagA:
13.61