SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		5 / 12 VAL A 160
LEU A  42
GLU A 357
HIS A 435
GLU A  39
 None
 1.47A 1mmkA-4payA:
undetectable		 1mmkA-4payA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		5 / 10 VAL A 233
ILE A 306
GLY A 307
ILE A 313
LEU A 259
 None
 1.04A 1z11C-4payA:
undetectable		 1z11C-4payA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		3 / 3 CYH A 468
HIS A 469
PHE A 460
 None
 1.07A 3cr4X-4payA:
undetectable		 3cr4X-4payA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		5 / 10 TYR A  19
ILE A  30
TYR A  76
ILE A 112
ILE A 116
 None
 1.11A 3p4wD-4payA:
undetectable		 3p4wD-4payA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		5 / 10 TYR A  19
ILE A  30
TYR A  76
ILE A 112
ILE A 116
 None
 1.11A 3p4wE-4payA:
2.9		 3p4wE-4payA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		5 / 12 ASN A 156
ILE A 439
TYR A 353
GLU A 357
ILE A 360
 None
 1.39A 3q5pA-4payA:
undetectable		 3q5pA-4payA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		3 / 3 HIS A 504
ARG A  16
GLU A  15
 None
 1.11A 3qf1A-4payA:
0.0		 3qf1A-4payA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		4 / 6 LEU A  52
TYR A  57
ALA A  69
LEU A 135
 None
 0.94A 3rd0A-4payA:
3.0		 3rd0A-4payA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		5 / 12 ALA A 451
ARG A 501
LEU A  42
THR A  48
PHE A 173
 None
 1.43A 3vhuA-4payA:
undetectable		 3vhuA-4payA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		4 / 4 TRP A 323
LEU A 263
LEU A 279
THR A 317
 None
 1.27A 4bboD-4payA:
undetectable		 4bboD-4payA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		5 / 12 SER A 348
GLN A 395
THR A 394
ILE A 399
PHE A 393
 None
 1.40A 4c49D-4payA:
0.0		 4c49D-4payA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		4 / 8 PHE A 376
ALA A 358
LEU A 416
LEU A 414
 None
 0.93A 4ejgB-4payA:
undetectable		 4ejgB-4payA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		4 / 7 PHE A 376
ALA A 358
LEU A 416
LEU A 414
 None
 0.93A 4ejgC-4payA:
undetectable		 4ejgC-4payA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		5 / 11 LEU A 536
VAL A 523
LEU A 527
LEU A 588
LEU A 592
 None
 1.11A 4p65B-4payA:
undetectable
4p65D-4payA:
undetectable
4p65G-4payA:
undetectable
4p65H-4payA:
undetectable		 4p65B-4payA:
4.70
4p65D-4payA:
4.70
4p65G-4payA:
3.59
4p65H-4payA:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		5 / 9 VAL A 300
LEU A 314
LEU A 252
LEU A 279
ILE A 256
 None
 1.30A 4ubsA-4payA:
1.9		 4ubsA-4payA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB406_0
(PROTON-GATED ION
CHANNEL)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		4 / 4 LEU A 297
ILE A 288
ARG A 284
TYR A 292
 None
 1.49A 4zzcB-4payA:
2.7		 4zzcB-4payA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		5 / 10 ILE A  34
ILE A 151
VAL A  35
THR A  48
ASN A  44
 None
 1.31A 5lg3F-4payA:
undetectable		 5lg3F-4payA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		4 / 7 THR A 312
LEU A 314
THR A 317
VAL A 322
 None
 1.05A 5ov9A-4payA:
2.4		 5ov9A-4payA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4pay SIDC, INTERAPTIN
(Legionella
pneumophila) 		4 / 7 TYR A  76
GLN A  72
ASP A  18
HIS A 462
 None
 1.17A 5ov9B-4payA:
undetectable		 5ov9B-4payA:
21.20