SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4pb0 AB53 LIGHT CHAIN
(Mus
musculus) 		4 / 4 LEU L 125
ILE L 150
ARG L 155
TRP L 148
 None
 1.42A 1ie9A-4pb0L:
undetectable		 1ie9A-4pb0L:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4pb0 AB53 LIGHT CHAIN
(Mus
musculus) 		5 / 11 GLY L  91
GLN L  90
GLY L  30
GLY L  30
ASP L  30
 None
 1.06A 1mxgA-4pb0L:
undetectable		 1mxgA-4pb0L:
16.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4pb0 AB53 HEAVY CHAIN
AB53 LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 6 TRP H 103
ASN L  34
LEU L  36
TRP L  89
PHE L  98
 None
 0.73A 1ru9H-4pb0H:
25.6
1ru9L-4pb0H:
15.5		 1ru9H-4pb0H:
66.67
1ru9L-4pb0H:
28.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUA_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4pb0 AB53 HEAVY CHAIN
AB53 LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 5 TRP H 103
ASN L  34
LEU L  36
TRP L  89
 None
 0.71A 1ruaH-4pb0H:
25.6
1ruaL-4pb0H:
15.5		 1ruaH-4pb0H:
66.67
1ruaL-4pb0H:
28.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4pb0 AB53 HEAVY CHAIN
AB53 LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 6 TRP H 103
ASN L  34
LEU L  36
TRP L  89
PHE L  98
 None
 0.78A 1rukH-4pb0H:
25.5
1rukL-4pb0H:
15.6		 1rukH-4pb0H:
66.67
1rukL-4pb0H:
28.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUL_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4pb0 AB53 HEAVY CHAIN
AB53 LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 5 TRP H 103
ASN L  34
LEU L  36
TRP L  89
 None
 0.73A 1rulH-4pb0H:
25.6
1rulL-4pb0H:
15.5		 1rulH-4pb0H:
66.67
1rulL-4pb0H:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4pb0 AB53 HEAVY CHAIN
AB53 LIGHT CHAIN
(Mus
musculus) 		5 / 12 ILE H  89
PHE L  98
LEU L  36
ILE L  85
GLN L  38
 None
 1.08A 1xozA-4pb0H:
undetectable		 1xozA-4pb0H:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4pb0 AB53 LIGHT CHAIN
(Mus
musculus) 		4 / 5 VAL L 132
VAL L 159
GLY L 158
TRP L 148
 None
 1.11A 2p2fA-4pb0L:
undetectable		 2p2fA-4pb0L:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4pb0 AB53 LIGHT CHAIN
(Mus
musculus) 		4 / 5 LEU L 125
ILE L 150
ARG L 155
TRP L 148
 None
 1.46A 2zlcA-4pb0L:
undetectable		 2zlcA-4pb0L:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		 4pb0 AB53 HEAVY CHAIN
AB53 LIGHT CHAIN
(Mus
musculus) 		5 / 10 SER H 180
MET L 175
SER L 174
LEU H 177
SER H 178
 None
 1.45A 3iltB-4pb0H:
undetectable
3iltE-4pb0H:
undetectable		 3iltB-4pb0H:
22.06
3iltE-4pb0H:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4pb0 AB53 HEAVY CHAIN
AB53 LIGHT CHAIN
(Mus
musculus) 		4 / 8 LEU L  36
TYR L  87
PHE L  98
TYR H  97
 None
 1.35A 3po7A-4pb0L:
undetectable		 3po7A-4pb0L:
18.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4pb0 AB53 HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
 CL  H 303 (-4.4A)
None
None
None
None
 0.93A 3qxvD-4pb0H:
18.7		 3qxvD-4pb0H:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 4pb0 AB53 LIGHT CHAIN
(Mus
musculus) 		4 / 7 ALA L  92
LEU L  30
SER L  28
SER L  25
 None
 0.96A 4iklA-4pb0L:
undetectable
4iklB-4pb0L:
undetectable		 4iklA-4pb0L:
20.54
4iklB-4pb0L:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 4pb0 AB53 LIGHT CHAIN
(Mus
musculus) 		4 / 8 SER L  25
ALA L  92
LEU L  30
SER L  28
 None
 1.00A 4iklA-4pb0L:
undetectable
4iklB-4pb0L:
undetectable		 4iklA-4pb0L:
20.54
4iklB-4pb0L:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		 4pb0 AB53 HEAVY CHAIN
AB53 LIGHT CHAIN
(Mus
musculus) 		5 / 11 ASN L  34
LEU L  36
ARG L  46
TRP L  89
TRP H 103
 None
 0.80A 5cp3A-4pb0L:
28.3
5cp3H-4pb0L:
15.5		 5cp3A-4pb0L:
94.91
5cp3H-4pb0L:
29.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4pb0 AB53 HEAVY CHAIN
(Mus
musculus) 		3 / 3 TYR H  59
GLY H  65
THR H  68
 None
None
CL  H 305 ( 4.6A)
 0.15A 6cjkB-4pb0H:
24.6		 6cjkB-4pb0H:
60.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 4pb0 AB53 LIGHT CHAIN
(Mus
musculus) 		4 / 6 ILE L  75
TYR L  86
LEU L  11
VAL L  78
 None
 1.17A 6f6jA-4pb0L:
undetectable		 6f6jA-4pb0L:
undetectable