SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pbc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 12 ASP A 261
ILE A 252
PHE A 219
VAL A 283
ILE A 263
 None
 1.17A 1c9hA-4pbcA:
undetectable		 1c9hA-4pbcA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		4 / 6 LEU A  71
TRP A  92
TYR A  19
VAL A  53
 None
 1.15A 1ibgH-4pbcA:
undetectable		 1ibgH-4pbcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		4 / 7 SER A 253
SER A 259
VAL A 255
LYS A 214
 None
 1.20A 2j9cA-4pbcA:
undetectable
2j9cB-4pbcA:
undetectable
2j9cC-4pbcA:
undetectable		 2j9cA-4pbcA:
16.46
2j9cB-4pbcA:
16.46
2j9cC-4pbcA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		4 / 6 PRO A  54
HIS A  62
ASP A  59
TYR A  56
 None
 1.40A 2lh8A-4pbcA:
undetectable		 2lh8A-4pbcA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 11 LEU A  71
LEU A  74
LEU A  78
ILE A  96
THR A 119
 None
 1.25A 2qd3A-4pbcA:
undetectable		 2qd3A-4pbcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		4 / 6 VAL A 114
LEU A 116
HIS A  70
LEU A  71
 None
None
PO4  A 401 ( 4.9A)
None
 0.83A 3kp6A-4pbcA:
undetectable
3kp6B-4pbcA:
undetectable		 3kp6A-4pbcA:
19.12
3kp6B-4pbcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		3 / 3 GLN A 117
PHE A 138
TYR A 115
 None
 0.95A 3ucjB-4pbcA:
undetectable		 3ucjB-4pbcA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A  71
LEU A  74
LEU A  78
ILE A  96
THR A 119
 None
 1.22A 4f4dA-4pbcA:
undetectable		 4f4dA-4pbcA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A  71
LEU A  74
LEU A  78
ILE A  96
THR A 119
 None
 1.14A 4f4dB-4pbcA:
undetectable		 4f4dB-4pbcA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 10 LEU A  71
LEU A  74
LEU A  78
ILE A  96
THR A 119
 None
 1.35A 4mk4A-4pbcA:
undetectable		 4mk4A-4pbcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		4 / 6 SER A  21
GLU A  26
ASP A  47
ARG A 120
 None
 0.83A 5cdnC-4pbcA:
undetectable
5cdnD-4pbcA:
undetectable		 5cdnC-4pbcA:
22.20
5cdnD-4pbcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		4 / 6 SER A  21
GLU A  26
ASP A  47
ARG A 120
 None
 0.83A 5cdnT-4pbcA:
undetectable
5cdnU-4pbcA:
undetectable		 5cdnT-4pbcA:
22.20
5cdnU-4pbcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		4 / 6 GLU A 188
GLY A  42
ASP A  40
GLY A  48
 None
 0.93A 5cdpA-4pbcA:
undetectable
5cdpB-4pbcA:
undetectable		 5cdpA-4pbcA:
23.08
5cdpB-4pbcA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 4pbc D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
cenocepacia) 		5 / 12 ASP A 261
ILE A 252
PHE A 219
VAL A 283
ILE A 263
 None
 1.18A 5hkgA-4pbcA:
undetectable		 5hkgA-4pbcA:
15.62