SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pbo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S14_A_NOVA1300_1 (TOPOISOMERASE IV SUBUNIT B)	4pbo	C-REACTIVE PROTEIN (Danio rerio)	5 / 12	SER A 142 ASP A 141 ASP A 148 ASP A 69 ARG A 68	None	1.40A	1s14A-4pboA: undetectable	1s14A-4pboA: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S14_B_NOVB2300_1 (TOPOISOMERASE IV SUBUNIT B)	4pbo	C-REACTIVE PROTEIN (Danio rerio)	5 / 12	SER A 142 ASP A 141 ASP A 148 ASP A 69 ARG A 68	None	1.34A	1s14B-4pboA: undetectable	1s14B-4pboA: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACL_A_REAA502_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	4pbo	C-REACTIVE PROTEIN (Danio rerio)	5 / 12	ALA A 109 GLN A 120 LEU A 74 ALA A 83 LEU A 167	None	0.91A	2aclA-4pboA: undetectable 2aclE-4pboA: undetectable	2aclA-4pboA: 24.15 2aclE-4pboA: 24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_C_KLNC1499_1 (CYTOCHROME P450 3A4)	4pbo	C-REACTIVE PROTEIN (Danio rerio)	4 / 7	PHE A 52 LEU A 28 ILE A 193 GLY A 132	None	0.90A	2v0mC-4pboA: undetectable	2v0mC-4pboA: 20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y00_B_Y00B601_2 (BETA-1 ADRENERGIC RECEPTOR)	4pbo	C-REACTIVE PROTEIN (Danio rerio)	3 / 3	VAL A 134 ASN A 63 TRP A 65	None	1.11A	2y00B-4pboA: undetectable	2y00B-4pboA: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LPS_A_NOVA901_1 (TOPOISOMERASE IV SUBUNIT B)	4pbo	C-REACTIVE PROTEIN (Danio rerio)	5 / 12	SER A 142 ASP A 141 ASP A 148 ASP A 69 ARG A 68	None	1.40A	3lpsA-4pboA: undetectable	3lpsA-4pboA: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O7G_A_ASCA303_0 (PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2)	4pbo	C-REACTIVE PROTEIN (Danio rerio)	4 / 7	PHE A 33 ILE A 128 PHE A 52 ASN A 63	None	1.42A	4o7gA-4pboA: undetectable 4o7gB-4pboA: undetectable	4o7gA-4pboA: 19.28 4o7gB-4pboA: 19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O7G_B_ASCB304_0 (PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2)	4pbo	C-REACTIVE PROTEIN (Danio rerio)	4 / 6	PHE A 33 ILE A 128 PHE A 52 ASN A 63	None	1.21A	4o7gB-4pboA: undetectable	4o7gB-4pboA: 19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWN_C_AQ4C602_0 (CYTOCHROME P450 1A1)	4pbo	C-REACTIVE PROTEIN (Danio rerio)	5 / 12	SER A 142 LEU A 22 ASP A 139 GLY A 137 PHE A 11	None	1.00A	6dwnC-4pboA: undetectable	6dwnC-4pboA: 17.22

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1S14_A_NOVA1300_1","TOPOISOMERASE IV SUBUNIT B","4pbo","C-REACTIVE PROTEIN","Danio rerio",5,"SER A 142;ASP A 141;ASP A 148;ASP A  69;ARG A  68","None","1.40A","1s14A-4pboA:undetectable","1s14A-4pboA:21.82"],["1S14_B_NOVB2300_1","TOPOISOMERASE IV SUBUNIT B","4pbo","C-REACTIVE PROTEIN","Danio rerio",5,"SER A 142;ASP A 141;ASP A 148;ASP A  69;ARG A  68","None","1.34A","1s14B-4pboA:undetectable","1s14B-4pboA:21.82"],["2ACL_A_REAA502_1","RETINOIC ACID RECEPTOR RXR-ALPHA;RETINOIC ACID RECEPTOR RXR-ALPHA","4pbo","C-REACTIVE PROTEIN","Danio rerio",5,"ALA A 109;GLN A 120;LEU A  74;ALA A  83;LEU A 167","None","0.91A","2aclA-4pboA:undetectable;2aclE-4pboA:undetectable","2aclA-4pboA:24.15;2aclE-4pboA:24.15"],["2V0M_C_KLNC1499_1","CYTOCHROME P450 3A4","4pbo","C-REACTIVE PROTEIN","Danio rerio",4,"PHE A  52;LEU A  28;ILE A 193;GLY A 132","None","0.90A","2v0mC-4pboA:undetectable","2v0mC-4pboA:20.30"],["2Y00_B_Y00B601_2","BETA-1 ADRENERGIC RECEPTOR","4pbo","C-REACTIVE PROTEIN","Danio rerio",3,"VAL A 134;ASN A  63;TRP A  65","None","1.11A","2y00B-4pboA:undetectable","2y00B-4pboA:18.45"],["3LPS_A_NOVA901_1","TOPOISOMERASE IV SUBUNIT B","4pbo","C-REACTIVE PROTEIN","Danio rerio",5,"SER A 142;ASP A 141;ASP A 148;ASP A  69;ARG A  68","None","1.40A","3lpsA-4pboA:undetectable","3lpsA-4pboA:19.22"],["4O7G_A_ASCA303_0","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","4pbo","C-REACTIVE PROTEIN","Danio rerio",4,"PHE A  33;ILE A 128;PHE A  52;ASN A  63","None","1.42A","4o7gA-4pboA:undetectable;4o7gB-4pboA:undetectable","4o7gA-4pboA:19.28;4o7gB-4pboA:19.28"],["4O7G_B_ASCB304_0","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","4pbo","C-REACTIVE PROTEIN","Danio rerio",4,"PHE A  33;ILE A 128;PHE A  52;ASN A  63","None","1.21A","4o7gB-4pboA:undetectable","4o7gB-4pboA:19.28"],["6DWN_C_AQ4C602_0","CYTOCHROME P450 1A1","4pbo","C-REACTIVE PROTEIN","Danio rerio",5,"SER A 142;LEU A  22;ASP A 139;GLY A 137;PHE A  11","None","1.00A","6dwnC-4pboA:undetectable","6dwnC-4pboA:17.22"]]