SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pbq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		4 / 8 TYR A 262
TYR A 142
LEU A 120
GLU A 105
 None
None
None
2UF  A 401 (-2.8A)
 1.01A 1i7zA-4pbqA:
undetectable		 1i7zA-4pbqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		4 / 7 LEU A 167
PHE A 295
MET A 299
VAL A 300
 None
 0.85A 1wrlA-4pbqA:
undetectable
1wrlB-4pbqA:
undetectable		 1wrlA-4pbqA:
12.89
1wrlB-4pbqA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		4 / 5 ILE A 231
PRO A 107
PHE A 110
VAL A 103
 None
 1.31A 2hjhB-4pbqA:
undetectable		 2hjhB-4pbqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		4 / 7 ILE A 225
SER A 216
TYR A 280
TYR A 219
 None
 1.42A 2xz5D-4pbqA:
undetectable
2xz5E-4pbqA:
undetectable		 2xz5D-4pbqA:
18.63
2xz5E-4pbqA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		3 / 3 THR A 273
GLU A 266
HIS A  32
 None
 0.78A 3g1uB-4pbqA:
undetectable		 3g1uB-4pbqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		4 / 7 GLU A 207
PHE A 175
HIS A  32
VAL A  77
 None
2UF  A 401 (-4.5A)
None
None
 0.92A 4a97D-4pbqA:
undetectable		 4a97D-4pbqA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		4 / 5 GLU A 207
ARG A 148
PRO A 170
SER A 188
 None
2UF  A 401 (-2.9A)
2UF  A 401 (-4.3A)
None
 1.38A 4k17B-4pbqA:
undetectable		 4k17B-4pbqA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		5 / 12 GLY A  31
GLY A  88
ILE A  85
ILE A  28
PHE A  48
 None
None
MES  A 403 (-4.6A)
None
None
 1.25A 4zvmA-4pbqA:
undetectable
4zvmB-4pbqA:
undetectable		 4zvmA-4pbqA:
20.66
4zvmB-4pbqA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		4 / 5 LEU A 109
LEU A  92
PHE A 110
LEU A 120
 None
2UF  A 401 (-4.3A)
None
None
 0.97A 5gtrA-4pbqA:
undetectable		 5gtrA-4pbqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		4 / 8 GLN A  69
GLY A  71
ILE A  85
GLN A 238
 None
None
MES  A 403 (-4.6A)
None
 0.92A 5vlmH-4pbqA:
undetectable		 5vlmH-4pbqA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		4 / 6 HIS A 230
ASN A 172
VAL A 169
LEU A 167
 None
2UF  A 401 (-3.9A)
None
None
 1.34A 5xdhA-4pbqA:
undetectable
5xdhC-4pbqA:
undetectable		 5xdhA-4pbqA:
14.98
5xdhC-4pbqA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		4 / 5 HIS A 230
ASN A 172
VAL A 169
LEU A 167
 None
2UF  A 401 (-3.9A)
None
None
 1.29A 5xdhB-4pbqA:
undetectable		 5xdhB-4pbqA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		4 / 5 HIS A 230
ASN A 172
VAL A 169
LEU A 167
 None
2UF  A 401 (-3.9A)
None
None
 1.35A 5xdhD-4pbqA:
undetectable		 5xdhD-4pbqA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		5 / 12 LEU A 218
PRO A 170
ILE A 203
VAL A 202
THR A 196
 None
2UF  A 401 (-4.3A)
None
None
None
 1.21A 6debB-4pbqA:
undetectable		 6debB-4pbqA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 4pbq PUTATIVE TRAP
PERIPLASMIC SOLUTE
BINDING PROTEIN
(Haemophilus
influenzae) 		4 / 5 THR A 243
THR A  90
GLN A 238
ASP A  74
 None
 1.49A 6ecxA-4pbqA:
undetectable		 6ecxA-4pbqA:
20.76