SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pbv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus) 		4 / 8 VAL C 123
ARG C  76
ALA C  49
GLU C 101
 None
 1.12A 1dmiA-4pbvC:
undetectable
1dmiB-4pbvC:
undetectable		 1dmiA-4pbvC:
20.69
1dmiB-4pbvC:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_A_H4BA1600_1
(NITRIC-OXIDE
SYNTHASE)		 4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus) 		4 / 6 VAL C 123
ARG C  76
PHE C  77
GLU C 101
 None
 1.48A 1fopA-4pbvC:
undetectable
1fopB-4pbvC:
undetectable		 1fopA-4pbvC:
20.69
1fopB-4pbvC:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
(Gallus
gallus) 		5 / 12 SER A 250
GLY A 279
ASN A 218
LEU A 282
LEU A 248
 None
 1.27A 1lhuA-4pbvA:
undetectable		 1lhuA-4pbvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
(Gallus
gallus) 		4 / 4 ASP A 133
HIS A  84
ARG A 111
GLU A  86
 None
 1.38A 1lqtA-4pbvA:
undetectable		 1lqtA-4pbvA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus) 		5 / 12 LEU C  95
LEU C 121
ALA C 212
PHE C 133
LEU C 129
 None
 1.00A 2h42C-4pbvC:
undetectable		 2h42C-4pbvC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus) 		5 / 12 ARG C  91
LEU C 121
PHE C  51
ALA C  49
VAL C  48
 None
 0.90A 2oc8A-4pbvC:
undetectable		 2oc8A-4pbvC:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
(Gallus
gallus) 		4 / 7 LEU A 146
PHE A 147
ARG A 156
THR A 109
 None
 1.06A 2zxwN-4pbvA:
undetectable
2zxwW-4pbvA:
undetectable		 2zxwN-4pbvA:
18.97
2zxwW-4pbvA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
(Gallus
gallus) 		4 / 7 LEU A 146
PHE A 147
ARG A 156
THR A 109
 None
 0.98A 3ag2N-4pbvA:
undetectable
3ag2W-4pbvA:
undetectable		 3ag2N-4pbvA:
18.97
3ag2W-4pbvA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
(Gallus
gallus) 		4 / 7 LEU A 146
PHE A 147
ARG A 156
THR A 109
 None
 1.01A 3ag4N-4pbvA:
undetectable
3ag4W-4pbvA:
undetectable		 3ag4N-4pbvA:
18.97
3ag4W-4pbvA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus) 		4 / 6 PHE C  77
GLU C 101
VAL C 123
ARG C  76
 None
 1.49A 3n5pA-4pbvC:
undetectable
3n5pB-4pbvC:
undetectable		 3n5pA-4pbvC:
20.69
3n5pB-4pbvC:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLD_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus) 		4 / 6 PHE C  77
GLU C 101
VAL C 123
ARG C  76
 None
 1.47A 3nldA-4pbvC:
undetectable
3nldB-4pbvC:
undetectable		 3nldA-4pbvC:
20.69
3nldB-4pbvC:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus) 		4 / 8 SER C 209
ASN C 210
GLY C  43
GLN C  41
 None
 0.92A 4af0A-4pbvC:
undetectable		 4af0A-4pbvC:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus) 		5 / 12 GLY C 202
TYR C 216
SER C  50
VAL C  52
VAL C  89
 None
 1.34A 4ffwA-4pbvC:
undetectable		 4ffwA-4pbvC:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus) 		5 / 12 GLY C 202
TYR C 216
SER C  50
VAL C  52
VAL C  89
 None
 1.34A 4ffwB-4pbvC:
undetectable		 4ffwB-4pbvC:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
(Gallus
gallus) 		5 / 12 LEU A 146
LEU A  94
ASN A 117
ILE A 132
ILE A 110
 None
 1.09A 4o2bB-4pbvA:
undetectable		 4o2bB-4pbvA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
(Gallus
gallus) 		4 / 6 LEU A 146
PHE A 147
ARG A 156
THR A 109
 None
 0.94A 5b1aN-4pbvA:
undetectable
5b1aW-4pbvA:
undetectable		 5b1aN-4pbvA:
18.97
5b1aW-4pbvA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus;
Gallus
gallus) 		4 / 8 LEU A 139
LEU A  94
TRP A 144
GLN C  75
 None
 0.78A 5hbsA-4pbvA:
undetectable		 5hbsA-4pbvA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
(Gallus
gallus) 		5 / 12 LEU A 152
LEU A 115
LEU A 139
PHE A 147
ALA A 122
 None
 1.00A 5ieoA-4pbvA:
undetectable		 5ieoA-4pbvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
(Gallus
gallus) 		5 / 12 LEU A 152
LEU A 115
LEU A 139
PHE A 147
ALA A 122
 None
 1.02A 5iepA-4pbvA:
undetectable		 5iepA-4pbvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus;
Gallus
gallus) 		4 / 8 LEU A 139
LEU A  94
TRP A 144
GLN C  75
 None
 0.73A 5ljbA-4pbvA:
undetectable		 5ljbA-4pbvA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
(Gallus
gallus) 		5 / 12 LEU A 146
LEU A  94
ASN A 117
ILE A 132
ILE A 110
 None
 1.10A 5mioB-4pbvA:
undetectable		 5mioB-4pbvA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
(Gallus
gallus) 		5 / 12 LEU A 146
LEU A  94
ASN A 117
ILE A 132
ILE A 110
 None
 1.04A 5nm5B-4pbvA:
undetectable		 5nm5B-4pbvA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus) 		4 / 6 PHE C  77
GLU C 101
VAL C 123
ARG C  76
 None
 1.49A 5uo8A-4pbvC:
undetectable
5uo8B-4pbvC:
undetectable		 5uo8A-4pbvC:
21.83
5uo8B-4pbvC:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus) 		4 / 7 VAL C 123
ARG C  76
PHE C  77
GLU C 101
 None
 1.48A 5vv9A-4pbvC:
undetectable
5vv9B-4pbvC:
undetectable		 5vv9A-4pbvC:
20.73
5vv9B-4pbvC:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
(Gallus
gallus) 		5 / 12 LEU A 142
ILE A 118
TYR A 102
LEU A 105
ILE A 132
 None
 1.15A 5y2tB-4pbvA:
undetectable		 5y2tB-4pbvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM
(Gallus
gallus;
Gallus
gallus) 		4 / 6 SER A 143
ARG C  76
ARG A 121
ASP A 242
 None
 1.31A 5zw4A-4pbvA:
undetectable		 5zw4A-4pbvA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4pbv NT-3 GROWTH FACTOR
RECEPTOR
(Gallus
gallus) 		4 / 6 ASP A 133
GLN A 185
LEU A 187
PHE A 162
 None
 1.26A 6ekuA-4pbvA:
undetectable		 6ekuA-4pbvA:
16.14