SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pbx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 PHE A 547
GLU A 549
ARG A 558
ILE A 528
 None
 1.41A 1nsiA-4pbxA:
undetectable
1nsiB-4pbxA:
undetectable		 1nsiA-4pbxA:
21.91
1nsiB-4pbxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 7 PHE A 234
ALA A 309
ILE A 251
PRO A 238
 None
 1.05A 1oniA-4pbxA:
undetectable
1oniB-4pbxA:
undetectable		 1oniA-4pbxA:
13.68
1oniB-4pbxA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 PHE A 234
ALA A 309
ILE A 251
PRO A 238
 None
 1.18A 1oniH-4pbxA:
undetectable
1oniI-4pbxA:
undetectable		 1oniH-4pbxA:
13.68
1oniI-4pbxA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 LYS A  40
ALA A 120
LEU A 122
VAL A 118
 None
 1.10A 1sn5A-4pbxA:
3.5		 1sn5A-4pbxA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 9 ARG A 228
THR A 149
VAL A 146
GLU A 147
SER A 196
 None
 1.39A 1z37A-4pbxA:
undetectable		 1z37A-4pbxA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		3 / 3 ARG A 597
ASN A 517
THR A 593
 None
 0.81A 2q63A-4pbxA:
undetectable		 2q63A-4pbxA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 SER A 235
ARG A 233
PRO A 232
GLY A 257
 None
 1.37A 2y7pA-4pbxA:
undetectable		 2y7pA-4pbxA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		3 / 3 GLN A 411
THR A 492
ASN A 441
 None
 0.91A 3v4tE-4pbxA:
undetectable		 3v4tE-4pbxA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 GLU A 270
GLY A 268
LEU A 272
TYR A 296
 None
 0.93A 3w9tB-4pbxA:
undetectable		 3w9tB-4pbxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 GLU A 270
GLY A 268
LEU A 272
TYR A 296
 None
 0.93A 3w9tE-4pbxA:
undetectable		 3w9tE-4pbxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 GLU A 270
GLY A 268
LEU A 272
TYR A 296
 None
 0.91A 3w9tF-4pbxA:
undetectable		 3w9tF-4pbxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 ALA A 294
GLN A 312
ASN A 295
ILE A 243
VAL A 315
 None
NAG  A 701 (-4.2A)
NAG  A 701 (-2.0A)
None
None
 1.18A 4azwA-4pbxA:
undetectable		 4azwA-4pbxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 GLY A 203
TYR A 217
SER A  51
VAL A  53
VAL A  90
 None
 1.17A 4ffwA-4pbxA:
undetectable		 4ffwA-4pbxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 GLY A 203
TYR A 217
SER A  51
VAL A  53
VAL A  90
 None
 1.17A 4ffwB-4pbxA:
undetectable		 4ffwB-4pbxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 5 LEU A 545
TYR A 543
LEU A 530
TYR A 566
 None
 1.41A 5ki6A-4pbxA:
undetectable		 5ki6A-4pbxA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		3 / 3 LYS A  35
GLN A 110
ASN A 111
 None
 1.02A 5l2tA-4pbxA:
undetectable		 5l2tA-4pbxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 8 HIS A 465
VAL A 486
THR A 473
TRP A 434
 None
 0.82A 5tt3H-4pbxA:
undetectable		 5tt3H-4pbxA:
15.01