SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pc7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3V_A_TOPA1169_1 (DIHYDROFOLATE REDUCTASE)	4pc7	ELONGATION FACTOR TS (Escherichia coli)	5 / 12	VAL C 60 ASP C 93 LEU C 96 SER C 144 ILE C 61	None	1.09A	2w3vA-4pc7C: undetectable	2w3vA-4pc7C: 20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X3U_B_SVRB102_1 (CHROMOBOX PROTEIN HOMOLOG 7)	4pc7	ELONGATION FACTOR TS (Escherichia coli)	3 / 3	LYS C 51 ARG C 132 VAL C 260	None	1.05A	4x3uA-4pc7C: undetectable 4x3uB-4pc7C: undetectable	4x3uA-4pc7C: 14.40 4x3uB-4pc7C: 14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HFJ_G_SAMG301_0 (ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA))	4pc7	ELONGATION FACTOR TS (Escherichia coli)	5 / 12	ALA C 56 ASP C 80 GLN C 89 LYS C 84 GLY C 59	None	1.37A	5hfjG-4pc7C: undetectable	5hfjG-4pc7C: 23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGD_A_ACTA812_0 (GEPHYRIN)	4pc7	ELONGATION FACTOR TS (Escherichia coli)	4 / 6	GLU C 262 ARG C 133 PHE C 258 VAL C 153	None	0.97A	6fgdA-4pc7C: undetectable	6fgdA-4pc7C: 21.74

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2W3V_A_TOPA1169_1","DIHYDROFOLATE REDUCTASE","4pc7","ELONGATION FACTOR TS","Escherichia coli",5,"VAL C  60;ASP C  93;LEU C  96;SER C 144;ILE C  61","None","1.09A","2w3vA-4pc7C:undetectable","2w3vA-4pc7C:20.07"],["4X3U_B_SVRB102_1","CHROMOBOX PROTEIN HOMOLOG 7;CHROMOBOX PROTEIN HOMOLOG 7","4pc7","ELONGATION FACTOR TS","Escherichia coli",3,"LYS C  51;ARG C 132;VAL C 260","None","1.05A","4x3uA-4pc7C:undetectable;4x3uB-4pc7C:undetectable","4x3uA-4pc7C:14.40;4x3uB-4pc7C:14.40"],["5HFJ_G_SAMG301_0","ADENINE SPECIFIC DNA METHYLTRANSFERASE (DPNA)","4pc7","ELONGATION FACTOR TS","Escherichia coli",5,"ALA C  56;ASP C  80;GLN C  89;LYS C  84;GLY C  59","None","1.37A","5hfjG-4pc7C:undetectable","5hfjG-4pc7C:23.16"],["6FGD_A_ACTA812_0","GEPHYRIN","4pc7","ELONGATION FACTOR TS","Escherichia coli",4,"GLU C 262;ARG C 133;PHE C 258;VAL C 153","None","0.97A","6fgdA-4pc7C:undetectable","6fgdA-4pc7C:21.74"]]