SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pc9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		4 / 7 VAL A 224
SER A 218
LEU A 215
ALA A  37
 None
None
CS2  A 401 (-4.2A)
None
 0.88A 1j8uA-4pc9A:
undetectable		 1j8uA-4pc9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 ASN A 174
VAL A 175
ILE A 238
LEU A 215
ALA A 107
 None
CS2  A 401 (-4.6A)
CS2  A 401 (-4.9A)
CS2  A 401 (-4.2A)
None
 1.31A 2iyfB-4pc9A:
undetectable		 2iyfB-4pc9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		4 / 6 SER A 251
ASP A 254
ASP A 253
GLU A  28
 None
 0.92A 2j2pE-4pc9A:
undetectable
2j2pF-4pc9A:
undetectable		 2j2pE-4pc9A:
19.94
2j2pF-4pc9A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 ARG A 151
GLU A  94
LEU A 106
GLU A  75
ARG A 171
 CS2  A 401 (-3.0A)
CS2  A 401 (-2.5A)
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.35A 3k37B-4pc9A:
undetectable		 3k37B-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 GLU A  94
LEU A 106
ALA A  37
GLU A  75
ARG A 171
 CS2  A 401 (-2.5A)
None
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.17A 3k37B-4pc9A:
undetectable		 3k37B-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 GLU A  94
LEU A 106
ALA A  37
GLU A  75
ARG A 171
 CS2  A 401 (-2.5A)
None
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.15A 3k39D-4pc9A:
undetectable		 3k39D-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 GLU A  94
LEU A 106
ALA A  37
GLU A  75
ARG A 171
 CS2  A 401 (-2.5A)
None
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.14A 3k39N-4pc9A:
undetectable		 3k39N-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 ARG A 151
GLU A  94
LEU A 106
GLU A  75
ARG A 171
 CS2  A 401 (-3.0A)
CS2  A 401 (-2.5A)
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.31A 3k39O-4pc9A:
undetectable		 3k39O-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 GLU A  94
LEU A 106
ALA A  37
GLU A  75
ARG A 171
 CS2  A 401 (-2.5A)
None
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.12A 3k39O-4pc9A:
undetectable		 3k39O-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 GLU A  94
LEU A 106
ALA A  37
GLU A  75
ARG A 171
 CS2  A 401 (-2.5A)
None
None
CS2  A 401 (-2.8A)
CS2  A 401 (-2.9A)
 1.15A 3k39P-4pc9A:
undetectable		 3k39P-4pc9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		3 / 3 VAL A 175
VAL A 234
SER A 236
 CS2  A 401 (-4.6A)
None
None
 0.68A 3n8xB-4pc9A:
undetectable		 3n8xB-4pc9A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 LEU A 115
GLY A 271
LEU A 272
GLU A 269
SER A 276
 None
 1.14A 3tbgA-4pc9A:
undetectable		 3tbgA-4pc9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 LEU A 115
GLY A 271
LEU A 272
GLU A 269
SER A 276
 None
 1.13A 3tbgC-4pc9A:
undetectable		 3tbgC-4pc9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 11 ASN A 174
VAL A 175
ILE A 238
LEU A 215
ALA A 107
 None
CS2  A 401 (-4.6A)
CS2  A 401 (-4.9A)
CS2  A 401 (-4.2A)
None
 1.34A 4m83A-4pc9A:
undetectable		 4m83A-4pc9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		3 / 3 ARG A 151
HIS A 233
SER A 236
 CS2  A 401 (-3.0A)
None
None
 1.02A 4mjwA-4pc9A:
undetectable
4mjwB-4pc9A:
undetectable		 4mjwA-4pc9A:
23.97
4mjwB-4pc9A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 LEU A 201
GLY A 208
GLN A 209
LEU A 153
MET A 168
 None
 1.44A 4ojbA-4pc9A:
undetectable		 4ojbA-4pc9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 11 LEU A 115
GLY A 271
LEU A 272
GLU A 269
SER A 276
 None
 1.14A 4wnuA-4pc9A:
undetectable		 4wnuA-4pc9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 11 LEU A 115
GLY A 271
LEU A 272
GLU A 269
SER A 276
 None
 1.11A 4wnuC-4pc9A:
undetectable		 4wnuC-4pc9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		4 / 5 ARG A 316
LEU A 308
ASN A 310
VAL A 307
 None
 1.44A 5cshB-4pc9A:
undetectable		 5cshB-4pc9A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		4 / 8 ALA A 122
ILE A 130
ILE A 126
GLU A 125
 None
 0.76A 5mvmA-4pc9A:
undetectable
5mvmB-4pc9A:
undetectable		 5mvmA-4pc9A:
12.78
5mvmB-4pc9A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		4 / 5 ARG A 316
LEU A 308
ASN A 310
VAL A 307
 None
 1.41A 5os7B-4pc9A:
undetectable		 5os7B-4pc9A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		3 / 3 GLY A 127
THR A  90
PRO A 142
 None
 0.67A 5v5zA-4pc9A:
undetectable		 5v5zA-4pc9A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 LEU A 215
ILE A  91
VAL A  66
LEU A 273
ALA A  42
 CS2  A 401 (-4.2A)
None
None
None
None
 1.18A 6djzA-4pc9A:
undetectable		 6djzA-4pc9A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		3 / 3 LEU A 277
LEU A 115
ARG A 270
 None
 0.68A 6fgcA-4pc9A:
undetectable		 6fgcA-4pc9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		4 / 5 ARG A 316
LEU A 308
ASN A 310
VAL A 307
 None
 1.41A 6gmdA-4pc9A:
undetectable		 6gmdA-4pc9A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 VAL A 121
ILE A 126
SER A 324
VAL A 319
ILE A 318
 None
 1.50A 6gsdA-4pc9A:
undetectable		 6gsdA-4pc9A:
19.53