SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pcg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 4pcg VP1
(Human
polyomavirus
6) 		4 / 7 SER A 212
SER A 267
ARG A 270
TYR A 266
 None
 1.16A 1ibgL-4pcgA:
undetectable		 1ibgL-4pcgA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 12 ALA A 194
ASP A 195
ASP A 144
VAL A 182
GLY A 147
PRO A 188
 None
 1.48A 1k6cB-4pcgA:
undetectable		 1k6cB-4pcgA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 10 ALA A 194
ASP A 144
VAL A 182
GLY A 147
ILE A 148
PRO A 188
 None
 1.39A 1muiA-4pcgA:
undetectable		 1muiA-4pcgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 10 ALA A 194
ASP A 195
ASP A 144
VAL A 182
GLY A 147
PRO A 188
 None
 1.38A 1muiA-4pcgA:
undetectable		 1muiA-4pcgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 11 ALA A 194
ASP A 144
VAL A 182
GLY A 147
ILE A 148
PRO A 188
 None
 1.48A 1sdvB-4pcgA:
undetectable		 1sdvB-4pcgA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 11 ALA A 194
ASP A 195
ASP A 144
VAL A 182
GLY A 147
PRO A 188
 None
 1.37A 1sdvB-4pcgA:
undetectable		 1sdvB-4pcgA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 12 ALA A 194
ASP A 195
ASP A 144
VAL A 182
GLY A 147
PRO A 188
 None
 1.44A 2avoB-4pcgA:
undetectable		 2avoB-4pcgA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4pcg VP1
(Human
polyomavirus
6) 		5 / 9 GLY A 140
ILE A 243
ALA A 100
VAL A 282
PHE A 280
 None
 1.03A 2drdA-4pcgA:
undetectable		 2drdA-4pcgA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4pcg VP1
(Human
polyomavirus
6) 		4 / 8 GLY A 235
GLU A  99
ALA A 100
ASN A 201
 None
 0.76A 2dtjA-4pcgA:
undetectable
2dtjB-4pcgA:
undetectable		 2dtjA-4pcgA:
22.76
2dtjB-4pcgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 4pcg VP1
(Human
polyomavirus
6) 		4 / 8 THR A 124
GLY A 127
THR A 261
ILE A 119
 None
 0.76A 2f9wA-4pcgA:
undetectable
2f9wB-4pcgA:
undetectable		 2f9wA-4pcgA:
21.50
2f9wB-4pcgA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 12 ALA A 194
ASP A 144
VAL A 182
GLY A 147
ILE A 148
PRO A 188
 None
 1.44A 2q5kB-4pcgA:
undetectable		 2q5kB-4pcgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 12 ALA A 194
ASP A 195
ASP A 144
VAL A 182
GLY A 147
PRO A 188
 None
 1.24A 2q5kB-4pcgA:
undetectable		 2q5kB-4pcgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 11 ALA A 194
ASP A 195
ASP A 144
VAL A 182
GLY A 147
PRO A 188
 None
 1.49A 2qhcA-4pcgA:
undetectable		 2qhcA-4pcgA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 12 ALA A 194
ASP A 195
ASP A 144
VAL A 182
GLY A 147
PRO A 188
 None
 1.37A 2r5pB-4pcgA:
undetectable		 2r5pB-4pcgA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 12 ALA A 194
ASP A 144
VAL A 182
GLY A 147
ILE A 148
PRO A 188
 None
 1.41A 2z54B-4pcgA:
undetectable		 2z54B-4pcgA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 12 ALA A 194
ASP A 195
ASP A 144
VAL A 182
GLY A 147
PRO A 188
 None
 1.47A 2z54B-4pcgA:
undetectable		 2z54B-4pcgA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		4 / 7 GLY A 235
ILE A 236
VAL A  22
VAL A 289
 None
 0.77A 3ufnB-4pcgA:
undetectable		 3ufnB-4pcgA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 4pcg VP1
(Human
polyomavirus
6) 		4 / 4 LEU A 228
ILE A 243
GLY A 235
PHE A 284
 None
 1.14A 4dc3A-4pcgA:
undetectable		 4dc3A-4pcgA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 12 ALA A 194
ASP A 195
ASP A 144
VAL A 182
GLY A 147
PRO A 188
 None
 1.49A 4njuA-4pcgA:
undetectable		 4njuA-4pcgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 12 ALA A 194
ASP A 195
ASP A 144
VAL A 182
GLY A 147
PRO A 188
 None
 1.48A 4njuC-4pcgA:
undetectable		 4njuC-4pcgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4pcg VP1
(Human
polyomavirus
6) 		4 / 8 SER A 219
PHE A 220
GLY A 221
THR A 110
 None
 0.93A 5flcB-4pcgA:
undetectable		 5flcB-4pcgA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4pcg VP1
(Human
polyomavirus
6) 		4 / 8 SER A 219
PHE A 220
GLY A 221
THR A 110
 None
 0.93A 5flcF-4pcgA:
undetectable		 5flcF-4pcgA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4pcg VP1
(Human
polyomavirus
6) 		4 / 8 ALA A 185
THR A  77
THR A 246
ALA A  40
 SCN  A 301 (-3.5A)
SCN  A 301 ( 4.2A)
None
SCN  A 303 (-4.9A)
 0.95A 5x2tI-4pcgA:
undetectable
5x2tJ-4pcgA:
undetectable
5x2tK-4pcgA:
undetectable
5x2tL-4pcgA:
undetectable		 5x2tI-4pcgA:
19.48
5x2tJ-4pcgA:
20.68
5x2tK-4pcgA:
19.48
5x2tL-4pcgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 12 ALA A 194
ASP A 144
VAL A 182
GLY A 147
ILE A 148
PRO A 188
 None
 1.44A 6dj1B-4pcgA:
undetectable		 6dj1B-4pcgA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 12 ALA A 194
ASP A 195
ASP A 144
VAL A 182
GLY A 147
PRO A 188
 None
 1.29A 6dj1B-4pcgA:
undetectable		 6dj1B-4pcgA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 12 ALA A 194
ASP A 144
VAL A 182
GLY A 147
ILE A 148
PRO A 188
 None
 1.42A 6dj2B-4pcgA:
undetectable		 6dj2B-4pcgA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4pcg VP1
(Human
polyomavirus
6) 		6 / 12 ALA A 194
ASP A 195
ASP A 144
VAL A 182
GLY A 147
PRO A 188
 None
 1.30A 6dj2B-4pcgA:
undetectable		 6dj2B-4pcgA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4pcg VP1
(Human
polyomavirus
6) 		4 / 6 LEU A 262
THR A 261
GLY A 255
ARG A 270
 None
 1.34A 6gtqB-4pcgA:
undetectable
6gtqD-4pcgA:
undetectable		 6gtqB-4pcgA:
25.09
6gtqD-4pcgA:
10.50