SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 4pch VP1
(Human
polyomavirus
7) 		6 / 10 ALA A 191
ASP A 144
VAL A 179
GLY A 147
ILE A 148
PRO A 185
 None
 1.33A 1muiA-4pchA:
undetectable		 1muiA-4pchA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4pch VP1
(Human
polyomavirus
7) 		5 / 10 GLU A 187
SER A  65
THR A  63
ALA A  73
ALA A  72
 None
 1.35A 1wygA-4pchA:
undetectable		 1wygA-4pchA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 4pch VP1
(Human
polyomavirus
7) 		6 / 12 ALA A 191
ASP A 192
ASP A 144
VAL A 179
GLY A 147
PRO A 185
 None
 1.42A 2ieoA-4pchA:
undetectable		 2ieoA-4pchA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4pch VP1
(Human
polyomavirus
7) 		6 / 12 ALA A 191
ASP A 192
ASP A 144
VAL A 179
GLY A 147
PRO A 185
 None
 1.25A 2q5kB-4pchA:
undetectable		 2q5kB-4pchA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 4pch VP1
(Human
polyomavirus
7) 		6 / 11 ALA A 191
ASP A 144
VAL A 179
GLY A 147
ILE A 148
PRO A 185
 None
 1.49A 2qhcA-4pchA:
undetectable		 2qhcA-4pchA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 4pch VP1
(Human
polyomavirus
7) 		6 / 11 ALA A 191
ASP A 192
ASP A 144
VAL A 179
GLY A 147
PRO A 185
 None
 1.48A 2qhcA-4pchA:
undetectable		 2qhcA-4pchA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 4pch VP1
(Human
polyomavirus
7) 		6 / 12 ALA A 191
ASP A 144
VAL A 179
GLY A 147
ILE A 148
PRO A 185
 None
 1.39A 2z54B-4pchA:
undetectable		 2z54B-4pchA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 4pch VP1
(Human
polyomavirus
7) 		6 / 12 ALA A 191
ASP A 192
ASP A 144
VAL A 179
GLY A 147
PRO A 185
 None
 1.46A 2z54B-4pchA:
undetectable		 2z54B-4pchA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4pch VP1
(Human
polyomavirus
7) 		5 / 12 VAL A 145
THR A 199
PHE A 277
LEU A  42
ALA A 245
 None
 1.29A 3apxA-4pchA:
undetectable		 3apxA-4pchA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4pch VP1
(Human
polyomavirus
7) 		5 / 12 GLY A 208
GLY A 209
PRO A 150
VAL A 157
LEU A 155
 None
 1.03A 3m6wA-4pchA:
undetectable		 3m6wA-4pchA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4pch VP1
(Human
polyomavirus
7) 		4 / 6 GLU A 187
THR A  63
ALA A  73
ALA A  72
 None
 1.06A 3ns1C-4pchA:
undetectable		 3ns1C-4pchA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4pch VP1
(Human
polyomavirus
7) 		3 / 3 GLU A 104
ARG A 278
HIS A 280
 None
 0.80A 4kf9A-4pchA:
undetectable		 4kf9A-4pchA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 4pch VP1
(Human
polyomavirus
7) 		6 / 12 ALA A 191
ASP A 192
ASP A 144
VAL A 179
GLY A 147
PRO A 185
 None
 1.48A 4njuA-4pchA:
undetectable		 4njuA-4pchA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4pch VP1
(Human
polyomavirus
7) 		6 / 12 ALA A 191
ASP A 192
ASP A 144
VAL A 179
GLY A 147
PRO A 185
 None
 1.31A 6dj1B-4pchA:
undetectable		 6dj1B-4pchA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4pch VP1
(Human
polyomavirus
7) 		6 / 12 ALA A 191
ASP A 144
VAL A 179
GLY A 147
ILE A 148
PRO A 185
 None
 1.41A 6dj2B-4pchA:
undetectable		 6dj2B-4pchA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4pch VP1
(Human
polyomavirus
7) 		6 / 12 ALA A 191
ASP A 192
ASP A 144
VAL A 179
GLY A 147
PRO A 185
 None
 1.30A 6dj2B-4pchA:
undetectable		 6dj2B-4pchA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4pch VP1
(Human
polyomavirus
7) 		4 / 6 LEU A 259
THR A 258
GLY A 252
ARG A 267
 GOL  A 301 ( 4.7A)
None
None
None
 1.26A 6gtqB-4pchA:
undetectable
6gtqD-4pchA:
undetectable		 6gtqB-4pchA:
21.29
6gtqD-4pchA:
11.21