SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pcl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 12 GLY A  68
ALA A  71
SER A  70
GLY A  45
LEU A  48
 None
None
SAM  A 301 (-2.9A)
None
None
 0.91A 1fe2A-4pclA:
undetectable		 1fe2A-4pclA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 12 GLY A  68
ALA A  71
SER A  70
GLY A  45
LEU A  48
 None
None
SAM  A 301 (-2.9A)
None
None
 0.98A 1igxA-4pclA:
undetectable		 1igxA-4pclA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 12 GLY A  64
SER A  70
ALA A 117
ALA A 137
TYR A 145
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
SAM  A 301 ( 3.9A)
None
 0.58A 2avdA-4pclA:
28.0		 2avdA-4pclA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 12 GLY A  64
ALA A 117
ASP A 136
ALA A 137
TYR A 145
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
MN  A 303 ( 2.7A)
SAM  A 301 ( 3.9A)
None
 0.44A 2avdB-4pclA:
28.0		 2avdB-4pclA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		3 / 3 GLY A  64
GLU A  88
ASP A 136
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
 0.15A 2b25B-4pclA:
15.0		 2b25B-4pclA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 12 LEU A  35
GLY A  64
SER A  70
ASP A 136
ALA A 137
 None
SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
MN  A 303 ( 2.7A)
SAM  A 301 ( 3.9A)
 0.83A 2br4A-4pclA:
13.9		 2br4A-4pclA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 12 LEU A  35
GLY A  64
SER A  70
ASP A 136
ALA A 137
 None
SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
MN  A 303 ( 2.7A)
SAM  A 301 ( 3.9A)
 0.82A 2br4F-4pclA:
13.3		 2br4F-4pclA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		3 / 3 SER A  70
GLU A  88
ASP A 136
 SAM  A 301 (-2.9A)
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
 0.24A 2zthA-4pclA:
23.1		 2zthA-4pclA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 6 GLY A  64
SER A  70
ILE A  87
GLU A  88
ASP A 136
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
None
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
 0.30A 3a7eA-4pclA:
23.1		 3a7eA-4pclA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		3 / 3 SER A  70
GLU A  88
ASP A 136
 SAM  A 301 (-2.9A)
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
 0.13A 3bwmA-4pclA:
22.8		 3bwmA-4pclA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		3 / 3 SER A  70
GLU A  88
ASP A 136
 SAM  A 301 (-2.9A)
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
 0.16A 3bwyA-4pclA:
22.7		 3bwyA-4pclA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 11 GLU A  62
GLY A  64
ILE A  87
GLU A  88
ALA A 117
 SAM  A 301 ( 4.4A)
SAM  A 301 (-3.4A)
None
SAM  A 301 (-2.6A)
SAM  A 301 (-3.3A)
 0.62A 3dxyA-4pclA:
12.4		 3dxyA-4pclA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 12 VAL A  63
GLY A  64
GLU A  88
ASP A  90
ALA A 117
 None
SAM  A 301 (-3.4A)
SAM  A 301 (-2.6A)
SAM  A 301 (-4.1A)
SAM  A 301 (-3.3A)
 0.87A 3fuuA-4pclA:
14.0		 3fuuA-4pclA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		4 / 8 ILE A  84
ALA A  71
LEU A 106
ALA A  97
 None
 0.93A 3hrdA-4pclA:
undetectable
3hrdB-4pclA:
undetectable		 3hrdA-4pclA:
20.84
3hrdB-4pclA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 11 GLY A  64
ILE A  87
GLU A  88
ALA A 117
ASP A 136
 SAM  A 301 (-3.4A)
None
SAM  A 301 (-2.6A)
SAM  A 301 (-3.3A)
MN  A 303 ( 2.7A)
 0.62A 3nmuB-4pclA:
undetectable
3nmuJ-4pclA:
13.8		 3nmuB-4pclA:
21.43
3nmuJ-4pclA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 12 GLY A  64
ILE A  87
ALA A 117
ASP A 136
GLU A 209
 SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.3A)
MN  A 303 ( 2.7A)
None
 1.15A 3nvkI-4pclA:
14.4		 3nvkI-4pclA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 10 GLU A  62
GLY A  64
SER A  70
GLU A  88
ASP A 136
 SAM  A 301 ( 4.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
 0.27A 3s68A-4pclA:
23.1		 3s68A-4pclA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 12 GLY A  68
ALA A  71
SER A  70
GLY A  45
LEU A  48
 None
None
SAM  A 301 (-2.9A)
None
None
 0.92A 4e1gA-4pclA:
undetectable		 4e1gA-4pclA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 12 GLY A  68
ALA A  71
SER A  70
GLY A  45
LEU A  48
 None
None
SAM  A 301 (-2.9A)
None
None
 0.90A 4e1gB-4pclA:
undetectable		 4e1gB-4pclA:
16.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		12 / 12 ALA A  38
GLN A  39
LEU A  40
GLY A  64
CYH A  66
PHE A  69
ASP A  90
ASN A  93
GLU A 116
ALA A 117
ALA A 137
TYR A 145
 SAM  A 301 (-3.9A)
SAM  A 301 (-4.9A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.2A)
None
SAM  A 301 (-4.1A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.9A)
SAM  A 301 (-3.3A)
SAM  A 301 ( 3.9A)
None
 0.00A 4pclA-4pclA:
42.7		 4pclA-4pclA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 5 SER A  70
GLU A  88
LYS A  89
ASP A 136
ASN A 138
 SAM  A 301 (-2.9A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.2A)
MN  A 303 ( 2.7A)
SAM  A 301 (-3.4A)
 0.00A 4pclA-4pclA:
42.7		 4pclA-4pclA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		12 / 12 GLN A  39
LEU A  40
GLU A  62
GLY A  64
CYH A  66
PHE A  69
LYS A  89
ASN A  93
ALA A 117
ALA A 137
ASN A 138
TYR A 145
 SAM  A 301 (-4.9A)
SAM  A 301 (-3.7A)
SAM  A 301 ( 4.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.2A)
None
SAM  A 301 (-3.2A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.3A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.4A)
None
 0.22A 4pclB-4pclA:
40.6		 4pclB-4pclA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PCL_B_SAMB301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		4 / 4 SER A  70
GLU A  88
GLU A 116
ASP A 136
 SAM  A 301 (-2.9A)
SAM  A 301 (-2.6A)
SAM  A 301 (-3.9A)
MN  A 303 ( 2.7A)
 0.15A 4pclB-4pclA:
40.6		 4pclB-4pclA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		3 / 3 SER A  70
GLU A  88
ASP A 136
 SAM  A 301 (-2.9A)
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
 0.07A 4xudA-4pclA:
22.7		 4xudA-4pclA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		4 / 5 GLY A  64
SER A  70
GLU A  88
ASP A 136
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
 0.23A 4xueA-4pclA:
23.0		 4xueA-4pclA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 12 GLY A  64
ALA A 117
ALA A 137
ASN A 138
TYR A 145
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.4A)
None
 0.28A 4ymgA-4pclA:
25.8		 4ymgA-4pclA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 12 GLY A  64
ALA A 117
GLU A 116
ALA A 137
ASN A 138
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.9A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.4A)
 1.11A 4ymgA-4pclA:
25.8		 4ymgA-4pclA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		7 / 12 GLY A  64
SER A  70
ALA A 117
ASP A 136
ALA A 137
ASN A 138
TYR A 145
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.3A)
MN  A 303 ( 2.7A)
SAM  A 301 ( 3.9A)
SAM  A 301 (-3.4A)
None
 0.29A 4ymgB-4pclA:
25.0		 4ymgB-4pclA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		6 / 12 GLU A  62
GLY A  64
ALA A 117
ASP A 136
ALA A 137
TYR A 145
 SAM  A 301 ( 4.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
MN  A 303 ( 2.7A)
SAM  A 301 ( 3.9A)
None
 0.39A 5kvaA-4pclA:
27.3		 5kvaA-4pclA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		6 / 12 GLU A  62
GLY A  64
ALA A 117
ASP A 136
ALA A 137
TYR A 145
 SAM  A 301 ( 4.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
MN  A 303 ( 2.7A)
SAM  A 301 ( 3.9A)
None
 0.47A 5kvaB-4pclA:
27.2		 5kvaB-4pclA:
27.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LOG_A_LDPA1004_1
(PUTATIVE
O-METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		4 / 6 ASP A 136
LYS A 139
ASP A 162
ASN A 163
 MN  A 303 ( 2.7A)
MN  A 303 ( 3.9A)
MN  A 303 (-3.2A)
MN  A 303 (-2.5A)
 0.45A 5logA-4pclA:
28.4		 5logA-4pclA:
31.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		6 / 12 GLU A  62
GLY A  64
ALA A 117
PHE A 134
ALA A 137
TYR A 145
 SAM  A 301 ( 4.4A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
None
SAM  A 301 ( 3.9A)
None
 0.22A 5n5dA-4pclA:
29.6		 5n5dA-4pclA:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		4 / 7 LEU A  35
ILE A  87
GLU A  88
ASN A 138
 None
None
SAM  A 301 (-2.6A)
SAM  A 301 (-3.4A)
 1.01A 5n5dA-4pclA:
29.6		 5n5dA-4pclA:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 7 SER A  70
ILE A  87
GLU A  88
ASP A 136
ASN A 138
 SAM  A 301 (-2.9A)
None
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
SAM  A 301 (-3.4A)
 0.22A 5n5dA-4pclA:
29.6		 5n5dA-4pclA:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		6 / 12 GLU A  62
ILE A  87
ALA A 117
PHE A 134
ALA A 137
TYR A 145
 SAM  A 301 ( 4.4A)
None
SAM  A 301 (-3.3A)
None
SAM  A 301 ( 3.9A)
None
 0.22A 5n5dB-4pclA:
29.3		 5n5dB-4pclA:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		5 / 7 GLY A  64
SER A  70
GLU A  88
ASP A 136
ASN A 138
 SAM  A 301 (-3.4A)
SAM  A 301 (-2.9A)
SAM  A 301 (-2.6A)
MN  A 303 ( 2.7A)
SAM  A 301 (-3.4A)
 0.21A 5n5dB-4pclA:
29.3		 5n5dB-4pclA:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN
(Anaplasma
phagocytophilum) 		3 / 3 VAL A  19
ALA A  24
GLN A  49
 None
 0.67A 6gb9A-4pclA:
undetectable		 6gb9A-4pclA:
19.07