SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pcs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 TRP A 100
TYR A  82
ALA A  93
TRP A  77
 None
 1.37A 1dy4A-4pcsA:
undetectable		 1dy4A-4pcsA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 4 SER A 342
LEU A 291
TYR A 396
GLY A 345
 None
 1.44A 1liiA-4pcsA:
2.1		 1liiA-4pcsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 285
GLY A 286
ARG A 271
 None
SO4  A 502 ( 4.5A)
SO4  A 502 (-3.2A)
 0.49A 1t9wA-4pcsA:
undetectable		 1t9wA-4pcsA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ARG A 336
LYS A 328
HIS A  66
TRP A 227
 None
None
2M7  A 505 (-4.0A)
None
 1.33A 1u1jA-4pcsA:
9.9		 1u1jA-4pcsA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 SER A 180
PHE A 228
ALA A 246
LEU A 250
 None
 1.17A 2bxkA-4pcsA:
undetectable		 2bxkA-4pcsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 9 TYR A 168
VAL A 129
THR A 126
GLY A 371
ALA A 367
 IMD  A 503 (-4.9A)
None
None
None
None
 1.34A 2cojA-4pcsA:
undetectable
2cojB-4pcsA:
undetectable		 2cojA-4pcsA:
20.64
2cojB-4pcsA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 9 VAL A 129
THR A 126
GLY A 371
THR A 368
ALA A 367
 None
 1.46A 2cojA-4pcsA:
undetectable
2cojB-4pcsA:
undetectable		 2cojA-4pcsA:
20.64
2cojB-4pcsA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A 391
TYR A 396
PRO A 294
 None
 1.47A 2j9cC-4pcsA:
undetectable		 2j9cC-4pcsA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 225
VAL A 257
PHE A 226
ASN A 260
TYR A 283
 None
 1.48A 2y04B-4pcsA:
undetectable		 2y04B-4pcsA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 VAL A 181
ASN A 239
GLY A 240
ASP A 266
 None
 0.83A 2y05A-4pcsA:
undetectable
2y05B-4pcsA:
undetectable		 2y05A-4pcsA:
21.35
2y05B-4pcsA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 9 TYR A 463
THR A 435
GLY A 378
ALA A 380
THR A 398
 None
 1.32A 3jusB-4pcsA:
undetectable		 3jusB-4pcsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 149
ASP A 183
ASP A 188
 None
 0.85A 3ou7B-4pcsA:
undetectable		 3ou7B-4pcsA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 112
LEU A 161
ILE A 131
ALA A 118
MET A 120
 None
None
None
None
IMD  A 503 (-3.1A)
 1.04A 4a83A-4pcsA:
undetectable		 4a83A-4pcsA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLY A 286
SER A 285
TRP A 227
 SO4  A 502 ( 4.5A)
None
None
 0.84A 4e7cD-4pcsA:
0.6		 4e7cD-4pcsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PRO A 294
LEU A 298
TYR A 397
PRO A 423
PHE A 389
 None
 1.49A 4ifvA-4pcsA:
undetectable		 4ifvA-4pcsA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 263
ASN A 260
LEU A 213
VAL A 223
 None
 1.10A 4okbA-4pcsA:
undetectable		 4okbA-4pcsA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 428
VAL A 469
GLN A 466
 None
 0.61A 5qgjA-4pcsA:
undetectable		 5qgjA-4pcsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 428
VAL A 469
GLN A 466
 None
 0.64A 5qgmA-4pcsA:
undetectable		 5qgmA-4pcsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 428
VAL A 469
GLN A 466
 None
 0.59A 5qgnA-4pcsA:
undetectable		 5qgnA-4pcsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 428
VAL A 469
GLN A 466
 None
 0.66A 5qgyA-4pcsA:
undetectable		 5qgyA-4pcsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 428
VAL A 469
GLN A 466
 None
 0.65A 5qgzA-4pcsA:
undetectable		 5qgzA-4pcsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 428
VAL A 469
GLN A 466
 None
 0.68A 5qh0A-4pcsA:
undetectable		 5qh0A-4pcsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 428
VAL A 469
GLN A 466
 None
 0.66A 5qh2A-4pcsA:
undetectable		 5qh2A-4pcsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 428
VAL A 469
GLN A 466
 None
 0.66A 5qh3A-4pcsA:
undetectable		 5qh3A-4pcsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 428
VAL A 469
GLN A 466
 None
 0.61A 5qh5A-4pcsA:
undetectable		 5qh5A-4pcsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 428
VAL A 469
GLN A 466
 None
 0.62A 5qh6A-4pcsA:
undetectable		 5qh6A-4pcsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 428
VAL A 469
GLN A 466
 None
 0.64A 5qh7A-4pcsA:
undetectable		 5qh7A-4pcsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 428
VAL A 469
GLN A 466
 None
 0.65A 5qhhA-4pcsA:
undetectable		 5qhhA-4pcsA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 156
VAL A 151
ILE A 160
GLU A 163
 None
 0.94A 5z3jA-4pcsA:
undetectable		 5z3jA-4pcsA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 TRP A 117
LEU A 141
GLU A 163
TRP A 107
 None
 0.99A 6c71B-4pcsA:
undetectable		 6c71B-4pcsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4pcs ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PRO A 294
LEU A 298
TYR A 397
PRO A 423
PHE A 389
 None
 1.49A 6eliA-4pcsA:
undetectable		 6eliA-4pcsA:
10.55