SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pcv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4pcv BDCA (YJGI)
(Escherichia
coli) 		5 / 12 ALA A 113
ILE A  85
ARG A  63
LEU A 102
LEU A 153
 None
 1.30A 1eiiA-4pcvA:
undetectable		 1eiiA-4pcvA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4pcv BDCA (YJGI)
(Escherichia
coli) 		5 / 12 LEU A  76
ILE A 127
LEU A 160
VAL A  66
VAL A  69
 None
 1.13A 2ygpA-4pcvA:
undetectable		 2ygpA-4pcvA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4pcv BDCA (YJGI)
(Escherichia
coli) 		5 / 12 ILE A 130
GLY A  14
ALA A  55
VAL A  56
VAL A  23
 None
 1.08A 2yvlA-4pcvA:
8.2		 2yvlA-4pcvA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4pcv BDCA (YJGI)
(Escherichia
coli) 		5 / 12 ILE A 130
GLY A  14
ALA A  55
VAL A  56
VAL A  23
 None
 1.07A 2yvlB-4pcvA:
8.3		 2yvlB-4pcvA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4pcv BDCA (YJGI)
(Escherichia
coli) 		5 / 12 ILE A 130
GLY A  14
ALA A  55
VAL A  56
VAL A  23
 None
 1.03A 2yvlD-4pcvA:
8.0		 2yvlD-4pcvA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4pcv BDCA (YJGI)
(Escherichia
coli) 		5 / 12 ILE A 130
GLY A  14
ALA A  83
ALA A  55
VAL A  23
 None
 1.15A 2yvlD-4pcvA:
8.0		 2yvlD-4pcvA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4pcv BDCA (YJGI)
(Escherichia
coli) 		5 / 10 ALA A  53
THR A  54
ALA A  55
ALA A  48
VAL A  27
 None
 1.04A 4qvyK-4pcvA:
undetectable
4qvyL-4pcvA:
undetectable		 4qvyK-4pcvA:
21.26
4qvyL-4pcvA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4pcv BDCA (YJGI)
(Escherichia
coli) 		5 / 10 ALA A  53
THR A  54
ALA A  55
ALA A  48
VAL A  27
 None
 1.04A 4qvyY-4pcvA:
undetectable
4qvyZ-4pcvA:
undetectable		 4qvyY-4pcvA:
21.26
4qvyZ-4pcvA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4pcv BDCA (YJGI)
(Escherichia
coli) 		5 / 9 ALA A 113
ILE A  22
VAL A  23
GLY A  13
SER A  73
 None
 1.19A 4r20B-4pcvA:
undetectable		 4r20B-4pcvA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4pcv BDCA (YJGI)
(Escherichia
coli) 		5 / 12 GLY A   2
ALA A   3
PHE A  26
ALA A 217
VAL A 213
 None
 1.48A 4ryaA-4pcvA:
undetectable		 4ryaA-4pcvA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4pcv BDCA (YJGI)
(Escherichia
coli) 		4 / 4 ILE A 105
ASN A 106
ILE A 129
VAL A  81
 None
 1.02A 4uy87-4pcvA:
undetectable		 4uy87-4pcvA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4pcv BDCA (YJGI)
(Escherichia
coli) 		4 / 5 ILE A  22
ILE A 231
HIS A 229
VAL A 174
 None
 0.89A 5jmnA-4pcvA:
undetectable		 5jmnA-4pcvA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4pcv BDCA (YJGI)
(Escherichia
coli) 		4 / 5 ALA A 217
VAL A 213
PHE A   4
ILE A  22
 None
 0.99A 5of1B-4pcvA:
undetectable		 5of1B-4pcvA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4pcv BDCA (YJGI)
(Escherichia
coli) 		5 / 9 LEU A  10
VAL A  81
ILE A  67
PRO A 110
ALA A 109
 None
 1.22A 5og9A-4pcvA:
undetectable		 5og9A-4pcvA:
20.85