SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pcz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE
(Lactococcus
lactis) 		4 / 6 ARG A  11
TYR A 137
ASP A 202
GLU A   7
 None
 1.20A 1rjdA-4pczA:
undetectable		 1rjdA-4pczA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE
(Lactococcus
lactis) 		4 / 6 ARG A  11
TYR A 137
ASP A 202
GLU A   7
 None
 1.19A 1rjdB-4pczA:
undetectable		 1rjdB-4pczA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE
(Lactococcus
lactis) 		4 / 6 ARG A  11
TYR A 137
ASP A 202
GLU A   7
 None
 1.17A 1rjdC-4pczA:
undetectable		 1rjdC-4pczA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE
(Lactococcus
lactis) 		5 / 12 TYR A  79
GLY A 101
LEU A  84
LEU A  13
ILE A  52
 None
 1.10A 3ijdA-4pczA:
undetectable		 3ijdA-4pczA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE
(Lactococcus
lactis) 		5 / 12 TYR A  79
GLY A 101
LEU A  84
LEU A  13
ILE A  52
 None
 1.08A 3ijdB-4pczA:
undetectable		 3ijdB-4pczA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE
(Lactococcus
lactis) 		4 / 5 ILE A 204
PHE A 140
ASP A 139
GLU A 134
 None
 0.97A 3kp6A-4pczA:
undetectable
3kp6B-4pczA:
undetectable		 3kp6A-4pczA:
23.97
3kp6B-4pczA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE
(Lactococcus
lactis) 		4 / 5 GLU A   2
LEU A   3
GLN A 163
GLY A  56
 None
 1.19A 3pp1A-4pczA:
undetectable		 3pp1A-4pczA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE
(Lactococcus
lactis) 		3 / 3 ASP A 175
GLY A 261
TYR A 238
 None
 0.69A 3w9tC-4pczA:
undetectable		 3w9tC-4pczA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE
(Lactococcus
lactis) 		3 / 3 ASP A 175
GLY A 261
TYR A 238
 None
 0.69A 3w9tG-4pczA:
undetectable		 3w9tG-4pczA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE
(Lactococcus
lactis) 		5 / 12 MET A  32
THR A 113
ASP A 107
ALA A 106
ASP A  92
 None
GOL  A 302 (-2.7A)
None
None
None
 1.22A 5kvaA-4pczA:
undetectable		 5kvaA-4pczA:
22.61