SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pd4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		5 / 9 PHE C 329
LEU C 302
VAL C 301
THR C 308
VAL C 367
 3PH  C4006 ( 4.9A)
None
None
None
None
 1.44A 1dz8A-4pd4C:
undetectable		 1dz8A-4pd4C:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		5 / 11 GLY C 337
GLY C 340
ILE C 354
SER C 284
ALA C 355
 None
 0.97A 1x7pA-4pd4C:
undetectable
1x7pB-4pd4C:
undetectable		 1x7pA-4pd4C:
21.14
1x7pB-4pd4C:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		5 / 10 ILE C 281
ALA C 280
TYR C 359
ILE C 125
ILE C 299
 None
None
None
AOQ  C4003 ( 4.4A)
AOQ  C4003 (-4.6A)
 0.96A 2dm6A-4pd4C:
undetectable
2dm6B-4pd4C:
undetectable		 2dm6A-4pd4C:
21.78
2dm6B-4pd4C:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 125
ILE C 299
PHE C 296
ALA C 298
ALA C 280
 AOQ  C4003 ( 4.4A)
AOQ  C4003 (-4.6A)
None
None
None
 1.17A 2j0dA-4pd4C:
1.8		 2j0dA-4pd4C:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		5 / 12 GLY C 352
TYR C 348
PRO C 347
ILE C 281
ALA C 355
 None
 0.99A 2plwA-4pd4C:
undetectable		 2plwA-4pd4C:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		4 / 6 SER C 311
ARG C 107
ARG C 314
ILE C 212
 None
 1.17A 2q72A-4pd4C:
undetectable		 2q72A-4pd4C:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 125
LEU C 275
ILE C 122
PHE C 121
PHE C 333
 AOQ  C4003 ( 4.4A)
AOQ  C4003 (-3.8A)
None
3PH  C4006 ( 4.6A)
3PH  C4006 (-4.1A)
 1.01A 2ygqA-4pd4C:
undetectable		 2ygqA-4pd4C:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		4 / 5 GLN C  22
TYR C  16
LEU C 230
LYS C 228
 UQ6  C4005 (-2.8A)
None
None
None
 1.05A 3sugA-4pd4C:
undetectable		 3sugA-4pd4C:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		5 / 11 ALA C 181
THR C 148
ILE C 176
ASN C 173
SER C 172
 None
 1.10A 4bb2A-4pd4C:
undetectable
4bb2B-4pd4C:
undetectable		 4bb2A-4pd4C:
24.32
4bb2B-4pd4C:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		4 / 6 PHE C 329
LEU C 302
VAL C 301
VAL C 367
 3PH  C4006 ( 4.9A)
None
None
None
 1.12A 4ek1A-4pd4C:
undetectable		 4ek1A-4pd4C:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		4 / 7 PHE C 329
TYR C 359
PRO C 277
PHE C 278
 3PH  C4006 ( 4.9A)
None
None
AOQ  C4003 ( 4.6A)
 1.35A 4grqA-4pd4C:
undetectable
4grqC-4pd4C:
undetectable		 4grqA-4pd4C:
13.81
4grqC-4pd4C:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		4 / 6 THR C 148
VAL C 264
SER C 170
ASP C 255
 None
 1.11A 4iaqA-4pd4C:
4.5		 4iaqA-4pd4C:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		4 / 7 THR C 148
VAL C 264
SER C 170
ASP C 255
 None
 1.16A 4iarA-4pd4C:
4.0		 4iarA-4pd4C:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		6 / 12 GLY C 337
GLY C 340
ILE C 354
GLN C 353
SER C 284
ALA C 355
 None
 1.27A 5l0zA-4pd4C:
undetectable		 5l0zA-4pd4C:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		6 / 10 GLY C 337
GLY C 340
ILE C 354
GLN C 353
SER C 284
ALA C 355
 None
 1.38A 5l0zB-4pd4C:
undetectable		 5l0zB-4pd4C:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		3 / 3 SER C 170
HIS C 141
TYR C 136
 None
 1.03A 5y2tA-4pd4C:
undetectable		 5y2tA-4pd4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		4 / 5 ILE C 147
PHE C 129
ASN C  57
TYR C 136
 AOQ  C4003 (-4.8A)
AOQ  C4003 (-4.6A)
None
None
 1.20A 6a93B-4pd4C:
5.1		 6a93B-4pd4C:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		4 / 6 LEU C 275
TYR C 274
VAL C 194
PHE C 129
 AOQ  C4003 (-3.8A)
None
HEM  C4002 (-4.4A)
AOQ  C4003 (-4.6A)
 0.88A 6hd4B-4pd4C:
undetectable		 6hd4B-4pd4C:
11.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		10 / 10 TRP C  29
PHE C  94
MET C  97
ALA C  98
TYR C 102
TYR C 103
THR C 317
PHE C 326
PHE C 327
VAL C 330
 3PH  C4006 (-3.6A)
3PH  C4006 ( 4.8A)
3PH  C4006 ( 4.1A)
3PH  C4006 (-3.6A)
3PH  C4006 (-3.3A)
3PH  C4006 (-4.9A)
3PH  C4006 (-3.3A)
None
3PH  C4006 ( 4.9A)
3PH  C4006 ( 4.4A)
 0.35A 6hu9C-4pd4C:
5.6		 6hu9C-4pd4C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		12 / 12 TRP C  29
PHE C  94
MET C  95
MET C  97
ALA C  98
TYR C 102
TYR C 103
THR C 317
PHE C 327
VAL C 330
VAL C 334
TYR C 359
 3PH  C4006 (-3.6A)
3PH  C4006 ( 4.8A)
None
3PH  C4006 ( 4.1A)
3PH  C4006 (-3.6A)
3PH  C4006 (-3.3A)
3PH  C4006 (-4.9A)
3PH  C4006 (-3.3A)
3PH  C4006 ( 4.9A)
3PH  C4006 ( 4.4A)
None
None
 0.38A 6hu9N-4pd4C:
undetectable		 6hu9N-4pd4C:
100.00