SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pdb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4pdb 30S RIBOSOMAL
PROTEIN S8
(Bacillus
anthracis) 		3 / 3 ALA A 127
VAL A 154
TRP A 155
 None
 0.78A 1nt6A-4pdbA:
undetectable		 1nt6A-4pdbA:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4pdb 30S RIBOSOMAL
PROTEIN S8
(Bacillus
anthracis) 		3 / 3 ALA A 127
VAL A 154
TRP A 155
 None
 0.78A 1nt6B-4pdbA:
undetectable		 1nt6B-4pdbA:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pdb 30S RIBOSOMAL
PROTEIN S8
(Bacillus
anthracis) 		4 / 6 ILE A  69
ARG A  36
THR A  35
LEU A 100
 None
 0.89A 2einN-4pdbA:
undetectable
2einW-4pdbA:
undetectable		 2einN-4pdbA:
14.48
2einW-4pdbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4pdb 30S RIBOSOMAL
PROTEIN S8
(Bacillus
anthracis) 		5 / 12 ARG A 142
GLY A 125
GLY A 123
ALA A 127
LEU A  63
 None
 0.97A 3dh0B-4pdbA:
undetectable		 3dh0B-4pdbA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4pdb 30S RIBOSOMAL
PROTEIN S8
(Bacillus
anthracis) 		5 / 12 ALA A 141
GLY A 134
SER A 130
GLY A 148
GLY A 147
 None
A  I  26 ( 3.5A)
A  I  26 ( 2.5A)
U  I  15 ( 4.1A)
C  I  16 ( 3.7A)
 0.87A 3douA-4pdbA:
undetectable		 3douA-4pdbA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pdb 30S RIBOSOMAL
PROTEIN S8
(Bacillus
anthracis) 		4 / 6 ILE A  69
ARG A  36
THR A  35
LEU A 100
 None
 1.05A 3wg7N-4pdbA:
undetectable
3wg7W-4pdbA:
undetectable		 3wg7N-4pdbA:
14.48
3wg7W-4pdbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4pdb 30S RIBOSOMAL
PROTEIN S8
(Bacillus
anthracis) 		4 / 7 ILE A  37
ARG A  38
GLY A  99
VAL A 154
 None
 0.83A 4a3uB-4pdbA:
undetectable		 4a3uB-4pdbA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pdb 30S RIBOSOMAL
PROTEIN S8
(Bacillus
anthracis) 		4 / 7 GLU A  73
ILE A  75
GLU A  49
PHE A  86
 None
 1.08A 4a97A-4pdbA:
undetectable		 4a97A-4pdbA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pdb 30S RIBOSOMAL
PROTEIN S8
(Bacillus
anthracis) 		4 / 7 GLU A  73
ILE A  75
GLU A  49
PHE A  86
 None
 0.94A 4a97D-4pdbA:
undetectable		 4a97D-4pdbA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pdb 30S RIBOSOMAL
PROTEIN S8
(Bacillus
anthracis) 		4 / 7 ILE A  69
ARG A  36
THR A  35
LEU A 100
 None
 0.93A 5iy5N-4pdbA:
undetectable
5iy5W-4pdbA:
undetectable		 5iy5N-4pdbA:
14.48
5iy5W-4pdbA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pdb 30S RIBOSOMAL
PROTEIN S8
(Bacillus
anthracis) 		4 / 6 ILE A  69
ARG A  36
THR A  35
LEU A 100
 None
 0.98A 5z86N-4pdbA:
undetectable
5z86W-4pdbA:
undetectable		 5z86N-4pdbA:
14.48
5z86W-4pdbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pdb 30S RIBOSOMAL
PROTEIN S8
(Bacillus
anthracis) 		4 / 6 ILE A  69
ARG A  36
THR A  35
LEU A 100
 None
 1.00A 5zcoN-4pdbA:
undetectable
5zcoW-4pdbA:
undetectable		 5zcoN-4pdbA:
14.48
5zcoW-4pdbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4pdb 30S RIBOSOMAL
PROTEIN S8
(Bacillus
anthracis) 		5 / 12 LEU A 100
ILE A  59
ALA A  40
LEU A  83
LEU A  87
 None
 1.08A 6ie8A-4pdbA:
undetectable		 6ie8A-4pdbA:
22.73