SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pde'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 4pde PROTEIN FDHD
(Escherichia
coli) 		5 / 9 ASP A 188
ALA A 194
GLY A 185
PRO A 162
VAL A 163
 None
 1.11A 1hpvB-4pdeA:
undetectable		 1hpvB-4pdeA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4pde PROTEIN FDHD
(Escherichia
coli) 		4 / 5 TYR A 269
PRO A 272
LEU A 275
ARG A 265
 None
None
None
GDP  A 300 (-3.0A)
 1.14A 1i2wA-4pdeA:
undetectable		 1i2wA-4pdeA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 4pde PROTEIN FDHD
(Escherichia
coli) 		4 / 6 LEU A 157
GLU A 187
ALA A 173
LEU A 215
 None
 1.10A 1sn5A-4pdeA:
undetectable		 1sn5A-4pdeA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 4pde PROTEIN FDHD
(Escherichia
coli) 		5 / 11 ASP A 188
ALA A 194
GLY A 185
PRO A 162
VAL A 163
 None
 1.03A 2qhcA-4pdeA:
undetectable		 2qhcA-4pdeA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4pde PROTEIN FDHD
(Escherichia
coli) 		5 / 12 GLY A 133
GLY A  74
HIS A  52
ARG A 112
ILE A  75
 None
 1.34A 2y7kC-4pdeA:
undetectable		 2y7kC-4pdeA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pde PROTEIN FDHD
(Escherichia
coli) 		5 / 12 SER A 228
LEU A 198
LEU A 157
PHE A 237
LEU A 255
 None
 1.40A 3adxA-4pdeA:
undetectable		 3adxA-4pdeA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 4pde PROTEIN FDHD
(Escherichia
coli) 		5 / 9 ASP A 188
ALA A 194
GLY A 185
PRO A 162
VAL A 163
 None
 1.03A 3em4B-4pdeA:
undetectable		 3em4B-4pdeA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4pde PROTEIN FDHD
(Escherichia
coli) 		5 / 11 ASP A 188
ALA A 194
GLY A 185
PRO A 162
VAL A 163
 None
 1.01A 3oxxD-4pdeA:
undetectable		 3oxxD-4pdeA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4pde PROTEIN FDHD
(Escherichia
coli) 		4 / 6 VAL A  53
TYR A  47
GLU A  73
ILE A 132
 None
 1.15A 3q5sA-4pdeA:
undetectable		 3q5sA-4pdeA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 4pde PROTEIN FDHD
(Escherichia
coli) 		5 / 9 ASP A 188
ALA A 194
GLY A 185
PRO A 162
VAL A 163
 None
 1.06A 4ll3B-4pdeA:
undetectable		 4ll3B-4pdeA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pde PROTEIN FDHD
(Escherichia
coli) 		4 / 7 VAL A 214
LEU A 139
GLY A 232
SER A 228
 None
 0.90A 5f1aB-4pdeA:
undetectable		 5f1aB-4pdeA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pde PROTEIN FDHD
(Escherichia
coli) 		5 / 12 VAL A 214
LEU A 139
GLY A 232
SER A 228
LEU A 199
 None
 1.11A 5ikqA-4pdeA:
undetectable		 5ikqA-4pdeA:
20.11