SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 ILE A 195
ALA A 189
THR A 239
PRO A 220
ASN A 219
 None
None
None
None
EAX  A 401 (-2.8A)
 0.99A 1dhfA-4pdhA:
undetectable		 1dhfA-4pdhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 8 GLU A 154
VAL A 281
HIS A 125
ASP A 282
 None
 1.16A 1s3zA-4pdhA:
undetectable
1s3zB-4pdhA:
undetectable		 1s3zA-4pdhA:
19.80
1s3zB-4pdhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 ASP A 284
VAL A 281
HIS A  49
ALA A 126
PHE A 120
 None
 1.33A 2g70A-4pdhA:
undetectable		 2g70A-4pdhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 ASP A 284
VAL A 281
HIS A  49
ALA A 126
PHE A 120
 None
 1.36A 2g72A-4pdhA:
undetectable		 2g72A-4pdhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 ALA A 149
LEU A 150
THR A 274
PHE A  98
ILE A  54
 None
 1.27A 2jjpA-4pdhA:
undetectable		 2jjpA-4pdhA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		3 / 3 VAL A 281
ASP A 282
GLU A 154
 None
 0.71A 2qeuA-4pdhA:
undetectable		 2qeuA-4pdhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		3 / 3 VAL A 281
ASP A 282
GLU A 154
 None
 0.73A 2qeuC-4pdhA:
undetectable		 2qeuC-4pdhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 9 PHE A  57
ALA A  58
VAL A  61
GLU A  62
 None
 0.52A 2vufA-4pdhA:
undetectable		 2vufA-4pdhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 8 GLU A  82
SER A  99
HIS A 186
ARG A 179
 EAX  A 401 (-3.0A)
None
None
EAX  A 401 (-3.0A)
 1.26A 3b9lA-4pdhA:
undetectable		 3b9lA-4pdhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 4 THR A  73
VAL A  61
GLY A 273
THR A 274
 None
 0.98A 3cflA-4pdhA:
2.8		 3cflA-4pdhA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		6 / 11 LEU A 221
ALA A 226
GLY A 156
ILE A 225
SER A  48
VAL A 281
 None
 1.46A 3gyqB-4pdhA:
undetectable		 3gyqB-4pdhA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 ASP A 115
THR A 101
LEU A 138
GLY A 135
PHE A 120
 None
 1.36A 3n58C-4pdhA:
undetectable		 3n58C-4pdhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 5 GLU A  62
GLY A  66
TYR A  69
ASP A 262
 None
 1.35A 3w9tD-4pdhA:
undetectable		 3w9tD-4pdhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 7 GLY A 273
THR A 274
SER A  48
THR A  44
 None
None
None
EAX  A 401 ( 4.5A)
 0.75A 4ac9C-4pdhA:
undetectable		 4ac9C-4pdhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 11 HIS A  49
GLN A  50
ILE A  42
GLY A  81
GLY A  80
 None
EAX  A 401 (-3.2A)
None
None
None
 1.44A 4fglA-4pdhA:
undetectable
4fglB-4pdhA:
undetectable		 4fglA-4pdhA:
21.75
4fglB-4pdhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 MET A 250
ALA A 151
PHE A  57
VAL A  89
VAL A  61
 None
 1.29A 4ib4A-4pdhA:
undetectable		 4ib4A-4pdhA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 VAL A 108
ALA A 188
PHE A 323
PHE A 319
LEU A 114
 None
 1.28A 4ib4A-4pdhA:
undetectable		 4ib4A-4pdhA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 5 ASN A 183
PRO A 105
GLY A 102
ASP A 137
 None
 1.10A 4n48B-4pdhA:
undetectable		 4n48B-4pdhA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 LEU A 176
GLY A 216
GLN A 233
MET A 160
HIS A 241
 None
 1.37A 4olmA-4pdhA:
undetectable		 4olmA-4pdhA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 7 MET A 181
HIS A  49
GLY A 156
ASN A 155
 EAX  A 401 (-3.3A)
None
None
EAX  A 401 (-3.4A)
 1.36A 5a5zC-4pdhA:
undetectable		 5a5zC-4pdhA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 4 THR A 111
VAL A 104
PRO A 245
THR A 101
 None
 1.43A 5mthA-4pdhA:
undetectable
5mthH-4pdhA:
undetectable		 5mthA-4pdhA:
20.52
5mthH-4pdhA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		5 / 12 VAL A 281
MET A 181
GLY A 102
VAL A 104
PHE A 142
 None
EAX  A 401 (-3.3A)
None
None
None
 1.08A 6brdC-4pdhA:
undetectable		 6brdC-4pdhA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Polaromonas
sp.
JS666) 		4 / 7 SER A 237
HIS A 241
GLY A 240
LEU A 173
 None
 1.11A 6btxA-4pdhA:
undetectable		 6btxA-4pdhA:
21.57