SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 430
PRO A 322
GLY A 395
MET A 394
 None
 0.96A 1hrkA-4pdsA:
undetectable		 1hrkA-4pdsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 430
PRO A 322
GLY A 395
MET A 394
 None
 0.96A 1hrkB-4pdsA:
undetectable		 1hrkB-4pdsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		4 / 8 MET A 394
PHE A 442
ALA A 457
ILE A 307
 None
 1.21A 1pnlA-4pdsA:
undetectable
1pnlB-4pdsA:
undetectable		 1pnlA-4pdsA:
20.46
1pnlB-4pdsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 324
HIS A 317
PHE A 340
ILE A 303
 ANP  A 601 (-3.3A)
None
None
None
 1.27A 1tdnA-4pdsA:
undetectable		 1tdnA-4pdsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 297
ILE A 325
GLY A 296
SER A 300
LEU A 304
 None
 0.90A 4e1gB-4pdsA:
undetectable		 4e1gB-4pdsA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		6 / 10 VAL A 212
VAL A 257
MET A 273
VAL A 276
LEU A 326
THR A 338
 ANP  A 601 (-4.4A)
None
ANP  A 601 (-4.3A)
ANP  A 601 (-4.3A)
ANP  A 601 (-4.7A)
ANP  A 601 ( 4.4A)
 0.72A 5n3hA-4pdsA:
11.5		 5n3hA-4pdsA:
28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 397
MET A 282
ILE A 443
LEU A 406
 None
 1.16A 5nfpA-4pdsA:
undetectable		 5nfpA-4pdsA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 4pds SERINE/THREONINE-PRO
TEIN KINASE RAD53
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 311
MET A 394
VAL A 389
LEU A 320
 None
 1.14A 5xdhA-4pdsA:
undetectable
5xdhC-4pdsA:
undetectable		 5xdhA-4pdsA:
11.53
5xdhC-4pdsA:
11.53