SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pdy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		5 / 9 LEU A 259
ARG A 262
PHE A 118
LEU A 131
LEU A 241
 None
 1.21A 2bxeA-4pdyA:
undetectable		 2bxeA-4pdyA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 ALA A  86
SER A 112
TRP A 110
VAL A  89
ALA A  56
 None
None
HIS  A 401 (-3.7A)
None
HIS  A 401 (-3.5A)
 1.22A 3qxvE-4pdyA:
undetectable		 3qxvE-4pdyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A 166
ARG A 163
TRP A 162
 None
 1.41A 4b7nA-4pdyA:
undetectable		 4b7nA-4pdyA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A 166
ARG A 163
TRP A 162
 None
 1.44A 4cpzC-4pdyA:
undetectable		 4cpzC-4pdyA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A 166
ARG A 163
TRP A 162
 None
 1.33A 4cpzE-4pdyA:
undetectable		 4cpzE-4pdyA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A 166
ARG A 163
TRP A 162
 None
 1.41A 4cpzF-4pdyA:
undetectable		 4cpzF-4pdyA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A 166
ARG A 163
TRP A 162
 None
 1.38A 4cpzG-4pdyA:
undetectable		 4cpzG-4pdyA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A 166
ARG A 163
TRP A 162
 None
 1.44A 4cpzH-4pdyA:
undetectable		 4cpzH-4pdyA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		4 / 7 LEU A 299
LYS A 334
PHE A 338
GLY A 271
 None
None
None
SCN  A 409 ( 4.7A)
 1.06A 4hbfA-4pdyA:
undetectable		 4hbfA-4pdyA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		4 / 7 LEU A 299
LYS A 334
PHE A 338
GLY A 271
 None
None
None
SCN  A 409 ( 4.7A)
 1.01A 4hc3A-4pdyA:
undetectable		 4hc3A-4pdyA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		5 / 10 ALA A  56
LYS A  58
THR A 108
VAL A 111
LEU A 232
 HIS  A 401 (-3.5A)
None
None
HIS  A 401 (-4.2A)
HIS  A 401 (-4.3A)
 0.91A 4rz7A-4pdyA:
8.2		 4rz7A-4pdyA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 PHE A 134
LEU A 131
LEU A 259
ARG A 262
ALA A 116
 None
 1.06A 4wcxC-4pdyA:
undetectable		 4wcxC-4pdyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 LEU A 254
LYS A 152
ALA A 297
VAL A 295
ALA A 257
 None
 1.23A 4x1iB-4pdyA:
undetectable		 4x1iB-4pdyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		4 / 7 LEU A 279
ALA A 125
GLN A 126
GLN A 345
 None
 1.28A 6b89A-4pdyA:
undetectable		 6b89A-4pdyA:
11.50