SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pe5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 4 HIS B 127
ALA B 100
PHE B  99
GLY B 128
 None
 1.22A 1mj2B-4pe5B:
undetectable		 1mj2B-4pe5B:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 4 HIS B 127
ALA B 100
PHE B  99
GLY B 128
 None
 1.17A 1mj2D-4pe5B:
undetectable		 1mj2D-4pe5B:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 4 HIS B 127
ALA B 100
PHE B  99
GLY B 128
 None
 1.20A 1mjoB-4pe5B:
undetectable		 1mjoB-4pe5B:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 4 HIS B 127
ALA B 100
PHE B  99
GLY B 128
 None
 1.19A 1mjoA-4pe5B:
undetectable		 1mjoA-4pe5B:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 4 HIS B 127
ALA B 100
PHE B  99
GLY B 128
 None
 1.20A 1mjoD-4pe5B:
undetectable		 1mjoD-4pe5B:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 6 ASP B 306
ILE B  37
PRO B 317
ILE B 314
 None
 0.91A 1n49D-4pe5B:
undetectable		 1n49D-4pe5B:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PB9_A_4AXA901_1
(N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT 1)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 9 LEU B 513
THR B 514
ARG B 519
SER B 690
ASP B 732
 GLU  B 921 (-4.5A)
GLU  B 921 (-3.7A)
GLU  B 921 (-2.4A)
GLU  B 921 (-3.2A)
GLU  B 921 (-4.2A)
 0.74A 1pb9A-4pe5B:
29.3		 1pb9A-4pe5B:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 5 ALA B 244
TYR B 239
ILE B 240
ASP B 211
 None
 1.21A 1upfA-4pe5B:
undetectable		 1upfA-4pe5B:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 5 ALA B 244
TYR B 239
ILE B 240
ASP B 211
 None
 1.11A 1upfC-4pe5B:
5.8		 1upfC-4pe5B:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 12 MET B 789
PHE B 784
ILE B 408
LEU B 478
ILE B 764
 None
 1.18A 2e7fA-4pe5B:
undetectable		 2e7fA-4pe5B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 12 MET B 789
PHE B 784
ILE B 408
LEU B 478
ILE B 764
 None
 1.23A 2e7fB-4pe5B:
undetectable		 2e7fB-4pe5B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 12 MET B 789
PHE B 784
ILE B 408
LEU B 478
ILE B 764
 None
 1.18A 2ogyA-4pe5B:
undetectable		 2ogyA-4pe5B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		3 / 3 GLY B 487
GLY B 499
GLY B 496
 None
 0.40A 3bogD-4pe5B:
undetectable		 3bogD-4pe5B:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 11 VAL B 409
ILE B 498
GLY B 499
LEU B 513
ALA B 765
 None
None
None
GLU  B 921 (-4.5A)
None
 1.22A 3kw2A-4pe5B:
4.7		 3kw2A-4pe5B:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		7 / 11 ALA B 107
GLN B 110
ILE B 111
PHE B 114
THR B 174
PRO B 177
GLU B 236
 QEL  B 920 ( 3.9A)
QEL  B 920 (-3.0A)
QEL  B 920 (-4.6A)
QEL  B 920 (-3.6A)
None
QEL  B 920 (-4.6A)
QEL  B 920 (-2.9A)
 0.28A 3qelA-4pe5B:
18.7
3qelB-4pe5B:
36.0		 3qelA-4pe5B:
18.61
3qelB-4pe5B:
99.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		9 / 9 PRO B  78
ALA B 107
GLN B 110
ILE B 111
PHE B 114
THR B 174
PHE B 176
PRO B 177
GLU B 236
 None
QEL  B 920 ( 3.9A)
QEL  B 920 (-3.0A)
QEL  B 920 (-4.6A)
QEL  B 920 (-3.6A)
None
None
QEL  B 920 (-4.6A)
QEL  B 920 (-2.9A)
 0.32A 3qelD-4pe5B:
24.5		 3qelD-4pe5B:
99.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 9 GLY B 125
PHE B 143
GLY B 128
PHE B  99
ASP B 101
 None
 1.16A 4h2gA-4pe5B:
undetectable		 4h2gA-4pe5B:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 12 LEU B 465
VAL B 417
LEU B 513
GLY B 511
ILE B 408
 None
None
GLU  B 921 (-4.5A)
None
None
 1.03A 4o5fA-4pe5B:
undetectable
4o5fB-4pe5B:
2.2		 4o5fA-4pe5B:
16.26
4o5fB-4pe5B:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 7 PRO B  78
GLU B 106
ASP B 206
THR B 174
 None
 1.27A 4uacA-4pe5B:
2.2		 4uacA-4pe5B:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		7 / 11 PRO B  78
ALA B 107
GLN B 110
ILE B 111
PHE B 114
PRO B 177
GLU B 236
 None
QEL  B 920 ( 3.9A)
QEL  B 920 (-3.0A)
QEL  B 920 (-4.6A)
QEL  B 920 (-3.6A)
QEL  B 920 (-4.6A)
QEL  B 920 (-2.9A)
 0.35A 5ewjA-4pe5B:
18.7
5ewjB-4pe5B:
36.1		 5ewjA-4pe5B:
18.60
5ewjB-4pe5B:
99.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		8 / 12 PRO B  78
ALA B 107
GLN B 110
ILE B 111
PHE B 114
THR B 174
PRO B 177
GLU B 236
 None
QEL  B 920 ( 3.9A)
QEL  B 920 (-3.0A)
QEL  B 920 (-4.6A)
QEL  B 920 (-3.6A)
None
QEL  B 920 (-4.6A)
QEL  B 920 (-2.9A)
 0.36A 5ewjC-4pe5B:
15.9
5ewjD-4pe5B:
35.7		 5ewjC-4pe5B:
18.60
5ewjD-4pe5B:
99.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 8 MET B 386
LEU B 366
ILE B 278
TYR B 252
 None
 0.87A 5ieoA-4pe5B:
undetectable		 5ieoA-4pe5B:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 9 MET B 386
VAL B 376
LEU B 366
ILE B 278
TYR B 252
 None
 1.16A 5iepA-4pe5B:
undetectable		 5iepA-4pe5B:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 9 VAL B 258
LEU B 249
ALA B 244
VAL B 243
SER B 246
 None
 1.26A 6c2mB-4pe5B:
undetectable		 6c2mB-4pe5B:
7.36